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公开(公告)号：US20220117738A1
公开(公告)日：2022-04-21
申请号：US17645940
申请日：2021-12-23
Applicant: Edwards Lifesciences Corporation
Inventor： Matthew T. Winston , Da-Yu Chang , Louis A. Campbell , James A. Davidson
IPC: A61F2/24
Abstract: Compressible heart valve annulus sizing templates suitable for minimally-invasive or otherwise reduced accessibility surgeries. The sizing templates may be folded, rolled, or otherwise compressed into a reduced configuration for passage through an access tube or other such access channel. Once expelled from the access tube the sizing templates expand to their original shape for use in sizing the annulus. The templates may be formed of an elastomeric polymer material such as silicone, a highly elastic metal such as NITINOL, or both. Grasping tabs or connectors for handles permit manipulation from outside the body. A NITINOL wireform may be compressed for passage through an access tube and expelled from the distal end thereof into a cloth cover to assume a sizer shape.
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公开(公告)号：US20190209174A1
公开(公告)日：2019-07-11
申请号：US16356604
申请日：2019-03-18
Applicant: Edwards Lifesciences Corporation
Inventor： Brian S. Conklin , James A. Davidson , Ralph Schneider
IPC: A61B17/10 , A61B17/068 , A61B17/064
CPC classification number: A61B17/10 , A61B17/064 , A61B17/068 , A61B17/105 , A61B2017/0645 , A61B2017/0649
Abstract: Devices and methods for deploying self-cinching surgical clips. A device can access at least two layers of tissue or material from only one side of the tissue or material and puncture through the two layers of tissue or material. The various configurations of clips disclosed herein can be made of a superelastic material such as Nitinol, and have a constrained and a relaxed state, and no sharp edges or tips so as to reduce tissue irritation following deployment. The clip can be disposed within the housing of the delivery device and held in a constrained state until deployment wherein the clip assumes its relaxed state, where the ends of the clip can be brought into close approximation, thereby securing the layers of tissue or material together.
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公开(公告)号：US20190151083A1
公开(公告)日：2019-05-23
申请号：US16253051
申请日：2019-01-21
Applicant: Edwards Lifesciences Corporation
Inventor： Jeffrey S. Dove , Darin P. Dobler , James A. Davidson , Gregory A. Wright
Abstract: A method for manufacturing a heart valve using bioprosthetic tissue that exhibits reduced in vivo calcification. The method includes applying a calcification mitigant such as a capping agent or an antioxidant to the tissue to specifically inhibit oxidation in tissue. Also, the method can be used to inhibit oxidation in dehydrated tissue. The capping agent suppresses the formation of binding sites in the tissue that are exposed or generated by the oxidation and otherwise would, upon implant, attract calcium, phosphate, immunogenic factors, or other precursors to calcification. In one method, tissue leaflets in assembled bioprosthetic heart valves are pretreated with an aldehyde capping agent prior to dehydration and sterilization.
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公开(公告)号：US10245037B2
公开(公告)日：2019-04-02
申请号：US15600072
申请日：2017-05-19
Applicant: Edwards Lifesciences Corporation
Inventor： Brian S. Conklin , James A. Davidson , Ralph Schneider
IPC: A61B17/10 , A61B17/064 , A61B17/068
Abstract: A device and method for deploying self-cinching surgical clips. The device accesses at least two layers of tissue or material from only one side of the tissue or material and punctures through the two layers of tissue or material. The various configurations of clips disclosed herein are made of a superelastic material such as Nitinol, and have a constrained and a relaxed state, and no sharp edges or tips so as to reduce tissue irritation following deployment. The clip is disposed within the housing of the delivery device and held in a constrained state by a tube assembly until deployment wherein the clip assumes its relaxed state, where the ends of the clip are brought into close approximation, thereby securing the layers of tissue or material together.
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公开(公告)号：US20180147323A1
公开(公告)日：2018-05-31
申请号：US15879339
申请日：2018-01-24
Applicant: Edwards Lifesciences Corporation
Inventor： James A. Davidson , Jeffrey S. Dove , Darin P. Dobler
CPC classification number: A61L27/3625 , A61F2/2412 , A61F2210/0004 , A61F2210/0076 , A61L27/3683 , A61L27/3687 , A61L27/3691 , A61L27/507 , A61L2400/02 , A61L2430/20 , A61L2430/40
Abstract: A treatment for bioprosthetic tissue used in implants or for assembled bioprosthetic heart valves to reduce in vivo calcification is disclosed. The method includes preconditioning, pre-stressing, or pre-damaging fixed bioprosthetic tissue in a manner that mimics the damage associated with post-implant use, while, and/or subsequently applying a calcification mitigant such as a capping agent or a linking agent to the damaged tissue. The capping agent suppresses the formation of binding sites in the tissue that are exposed or generated by the damage process (service stress) and otherwise would, upon implant, attract calcium, phosphate, immunogenic factors, or other precursors to calcification. The linking agent will act as an elastic reinforcement or shock-absorbing spring element in the tissue structure at the site of damage from the pre-stressing. In one method, tissue leaflets in assembled bioprosthetic heart valves are preconditioned by simulating actual flow conditions for a predetermined number of cycles, during or after which the valve is exposed to the capping agent.
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Patent Agency Ranking
公开(公告)号：US20170252040A1
公开(公告)日：2017-09-07
申请号：US15600072
申请日：2017-05-19
Applicant: Edwards Lifesciences Corporation
Inventor： Brian S. Conklin , James A. Davidson , Ralph Schneider
IPC: A61B17/10 , A61B17/064 , A61B17/068
CPC classification number: A61B17/10 , A61B17/064 , A61B17/068 , A61B17/105 , A61B2017/0645 , A61B2017/0649
Abstract: A device and method for deploying self-cinching surgical clips. The device accesses at least two layers of tissue or material from only one side of the tissue or material and punctures through the two layers of tissue or material. The various configurations of clips disclosed herein are made of a superelastic material such as Nitinol, and have a constrained and a relaxed state, and no sharp edges or tips so as to reduce tissue irritation following deployment. The clip is disposed within the housing of the delivery device and held in a constrained state by a tube assembly until deployment wherein the clip assumes its relaxed state, where the ends of the clip are brought into close approximation, thereby securing the layers of tissue or material together.
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公开(公告)号：US09668739B2
公开(公告)日：2017-06-06
申请号：US14637177
申请日：2015-03-03
Applicant: Edwards Lifesciences Corporation
Inventor： Brian S. Conklin , James A. Davidson , Ralph Schneider
IPC: A61B17/10 , A61B17/068 , A61B17/064
CPC classification number: A61B17/10 , A61B17/064 , A61B17/068 , A61B17/105 , A61B2017/0645 , A61B2017/0649
Abstract: A device and method for deploying self-cinching surgical clips. The device accesses at least two layers of tissue or material from only one side of the tissue or material and punctures through the two layers of tissue or material. The various configurations of clips disclosed herein are made of a superelastic material such as Nitinol, and have a constrained and a relaxed state, and no sharp edges or tips so as to reduce tissue irritation following deployment. The clip is disposed within the housing of the delivery device and held in a constrained state by a tube assembly until deployment wherein the clip assumes its relaxed state, where the ends of the clip are brought into close approximation, thereby securing the layers of tissue or material together.
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公开(公告)号：US20150173759A1
公开(公告)日：2015-06-25
申请号：US14637177
申请日：2015-03-03
Applicant: Edwards Lifesciences Corporation
Inventor： Brian S. Conklin , James A. Davidson , Ralph Schneider
IPC: A61B17/10
CPC classification number: A61B17/10 , A61B17/064 , A61B17/068 , A61B17/105 , A61B2017/0645 , A61B2017/0649
Abstract: A device and method for deploying self-cinching surgical clips. The device accesses at least two layers of tissue or material from only one side of the tissue or material and punctures through the two layers of tissue or material. The various configurations of clips disclosed herein are made of a superelastic material such as Nitinol, and have a constrained and a relaxed state, and no sharp edges or tips so as to reduce tissue irritation following deployment. The clip is disposed within the housing of the delivery device and held in a constrained state by a tube assembly until deployment wherein the clip assumes its relaxed state, where the ends of the clip are brought into close approximation, thereby securing the layers of tissue or material together.
Abstract translation: 一种用于部署自闭式手术夹的装置和方法。 该装置仅从组织或材料的一侧接近至少两层组织或材料，并穿刺穿过两层组织或材料。 本文公开的夹子的各种构造由超弹性材料（例如镍钛诺）制成，并且具有约束和松弛状态，并且没有锋利的边缘或尖端，以便在部署之后减少组织刺激。 夹子设置在输送装置的壳体内，并通过管组件保持在约束状态，直到展开为止，其中夹子呈现其松弛状态，其中夹子的端部被近似近似，从而固定组织层或 材料在一起
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公开(公告)号：US09029418B2
公开(公告)日：2015-05-12
申请号：US14139367
申请日：2013-12-23
Applicant: Edwards Lifesciences Corporation
Inventor： Jeffrey S. Dove , Darin P. Dobler , James A. Davidson , Gregory A. Wright
CPC classification number: A61F2/2415 , A61F2/0095 , A61F2/24 , A61F2/2412 , A61F2/2418 , A61L27/3604 , A61L27/3625 , A61L27/3629 , A61L27/3687 , A61L27/3691 , A61L27/507 , A61L2400/02 , A61L2430/20
Abstract: A treatment for bioprosthetic tissue used in implants or for assembled bioprosthetic heart valves to reduce in vivo calcification. The method includes applying a calcification mitigant such as a capping agent or an antioxidant to the tissue to specifically inhibit oxidation in tissue. Also, the method can be used to inhibit oxidation in dehydrated tissue. The capping agent suppresses the formation of binding sites in the tissue that are exposed or generated by the oxidation and otherwise would, upon implant, attract calcium, phosphate, immunogenic factors, or other precursors to calcification. In one method, tissue leaflets in assembled bioprosthetic heart valves are pretreated with an aldehyde capping agent prior to dehydration and sterilization.
Abstract translation: 用于植入物或组装的生物假体心脏瓣膜中用于减少体内钙化的生物假体组织的治疗。 该方法包括将钙化缓解剂如封端剂或抗氧化剂施用于组织以特异性抑制组织中的氧化。 此外，该方法可用于抑制脱水组织中的氧化。 封端剂抑制由氧化暴露或产生的组织中的结合位点的形成，否则在植入时会吸引钙，磷酸盐，免疫原性因子或钙化的其它前体。 在一种方法中，组装的生物假体心脏瓣膜中的组织小叶在脱水和灭菌之前用醛封端剂预处理。
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公开(公告)号：US08968336B2
公开(公告)日：2015-03-03
申请号：US13693952
申请日：2012-12-04
Applicant: Edwards Lifesciences Corporation
Inventor： Brian S. Conklin , James A. Davidson , Ralph Schneider
IPC: A61B17/10 , A61B17/068 , A61B17/064
CPC classification number: A61B17/10 , A61B17/064 , A61B17/068 , A61B17/105 , A61B2017/0645 , A61B2017/0649
Abstract: A device and method for deploying self-cinching surgical clips. The device accesses at least two layers of tissue or material from only one side of the tissue or material and punctures through the two layers of tissue or material. The various configurations of clips disclosed herein are made of a superelastic material such as Nitinol, and have a constrained and a relaxed state, and no sharp edges or tips so as to reduce tissue irritation following deployment. The clip is disposed within the housing of the delivery device and held in a constrained state by a tube assembly until deployment wherein the clip assumes its relaxed state, where the ends of the clip are brought into close approximation, thereby securing the layers of tissue or material together.
Abstract translation: 一种用于部署自闭式手术夹的装置和方法。 该装置仅从组织或材料的一侧接近至少两层组织或材料，并穿刺穿过两层组织或材料。 本文公开的夹子的各种构造由超弹性材料（例如镍钛诺）制成，并且具有约束和松弛状态，并且没有锋利的边缘或尖端，以便在部署之后减少组织刺激。 夹子设置在输送装置的壳体内，并通过管组件保持在约束状态，直到展开为止，其中夹子呈现其松弛状态，其中夹子的端部被近似逼近，由此固定组织层或 材料在一起
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