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98 条记录 (耗时 0.054 秒)

    Antibacterial 8-cyano-1-cyclopropyl-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids
    12.
    发明授权
    Antibacterial 8-cyano-1-cyclopropyl-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids 失效
    抗菌8-氰基-1-环丙基-1,4-二氢-4-氧代-3-喹啉羧酸

    公开(公告)号：US4908366A

    公开(公告)日：1990-03-13

    申请号：US144884

    申请日：1988-01-14

    申请人： Michael Schriewer ,  Klaus Grohe ,  Uwe Petersen ,  Ingo Haller ,  Karl G. Metzger ,  Rainer Endermann ,  Hans-Joachim Zeiler

    发明人： Michael Schriewer ,  Klaus Grohe ,  Uwe Petersen ,  Ingo Haller ,  Karl G. Metzger ,  Rainer Endermann ,  Hans-Joachim Zeiler

    IPC分类号： A61K31/47 ,  A61K31/495 ,  A61P31/04 ,  C07D215/56 ,  C07D401/04 ,  C07D487/08

    CPC分类号： C07D215/56 ,  C07D401/04 ,  C07D487/08

    摘要： Antibacterial 8-cyano-1-cyclopropyl-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid derivatives of the formula ##STR1## in which Y represents a carboxyl group, a nitrile group, an ester group --COOR.sup.1 or an acid amide group --CONR.sup.2 R.sup.3,X.sup.1 represents hydrogen nitro, alkyl or halogenX.sup.4 can be hydrogen or halogen, or alkyl,R.sup.4 and R.sup.5, together with the nitrogen atom to which they are bonded, form a 5- or 6-membered heterocyclic ring which can additionally contain the atoms or groups --O--, --S--, --SO--, --SO.sub.2 --, ##STR2## as ring members or the group ##STR3## can also represent a ring system of the structure ##STR4## which can optionally be substituted on the ring carbons by methyl and pharmaceutically usable hydrates, salts or esters thereof.These compounds have a high antibacterial activity and are therefore suitable as active compounds for human and veterinary medicine.

    摘要翻译： 其中Y表示羧基，腈基，酯基-COOR1或酸的式“IMAGE”的抗菌8-氰基-1-环丙基-1,4-二氢-4-氧代-3-喹啉羧酸衍生物 酰胺基-CONR2R3，X1表示氢硝基，烷基或卤素X4可以是氢或卤素，或烷基，R4和R5与它们所键合的氮原子一起形成5-或6-元杂环，其可以 另外还包含原子或基团-O - ， - S - ， - SO - ， - SO 2 - ，作为环成员或组也可以表示结构 + TR

    7-(3-aryl-1-piperazinyl)- and 7-(3-cyclohexyl-1-piperazinyl)-3-quinolonecarboxylic acid antibacterials
    13.
    发明授权
    7-(3-aryl-1-piperazinyl)- and 7-(3-cyclohexyl-1-piperazinyl)-3-quinolonecarboxylic acid antibacterials 失效
    7-（3-芳基-1-哌嗪基） - 和7-（3-环己基-1-哌嗪基）-3-喹诺酮羧酸抗菌剂

    公开(公告)号：US4599334A

    公开(公告)日：1986-07-08

    申请号：US735493

    申请日：1985-05-17

    申请人： Uwe Petersen ,  Klaus Grohe ,  Hans-Joachim Zeiler ,  Karl G. Metzger

    发明人： Uwe Petersen ,  Klaus Grohe ,  Hans-Joachim Zeiler ,  Karl G. Metzger

    IPC分类号： A61K31/495 ,  A61P3/00 ,  A61P31/04 ,  C07D215/56 ,  C07D333/00 ,  C07D401/04 ,  C07D409/14

    CPC分类号： C07D215/56 ,  C07D401/04 ,  C07D409/14

    摘要： Novel 1-cyclopropyl-4-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid antibacterials of the formula ##STR1## in which R.sup.1 is hydrogen, alkyl with 1 to 4 carbon atoms and optionally substituted by hydroxyl, methoxy, amino, dimethylamino, halogen, cyano or alkoxycarbonyl having 1 or 2 carbon atoms in the alkyl moiety, or is oxoalkyl having up to 4 carbon atoms, phenacyl, or acyl having 1 to 4 carbon atoms, phenacyl, or acyl having 1 to 4 carbon atoms,R.sup.2 is phenyl or cyclohexyl optionally substituted up to three times by halogen, methyl, phenyl, cyano, hydroxyl, methoxy, benzyloxy, amino, methylamino, dimethylamino, piperidino or nitro, or is methylenedioxyphenyl, methylenedioxycyclohexyl, furyl, tetrahydrofuryl or thienyl, andX.sup.1 is hydrogen or fluorine,or pharmaceutically ultizable hydrates, acid addition salts, alkali metal salts or alkaline earth metal salts thereof.

    摘要翻译： 具有式“IMAGE”的新颖的1-环丙基-4-氟-1,4-二氢-4-氧代-7-（1-哌嗪基）-3-喹啉羧酸抗菌剂，其中R 1是氢，具有1至4个的烷基 任选地被羟基，甲氧基，氨基，二甲基氨基，卤素，氰基或在烷基部分中具有1或2个碳原子的烷氧基羰基取代，或具有至多4个碳原子的氧代烷基，苯甲酰甲基或具有1至4个碳原子的酰基 ，苯甲酰基或具有1至4个碳原子的酰基，R 2是苯基或任选被卤素，甲基，苯基，氰基，羟基，甲氧基，苄氧基，氨基，甲基氨基，二甲基氨基，哌啶子基或硝基取代至多三次的苯基或环己基， 亚甲二氧基苯基，亚甲二氧基环己基，呋喃基，四氢呋喃基或噻吩基，X 1为氢或氟，或其药学上可接受的水合物，酸加成盐，碱金属盐或碱土金属盐。

    1-Cyclopropyl-1,4-dihydro-4-oxo-7-(4-(2-oxo-1,3-dioxol-4-yl- methyl)-1-piperazinyl)-3-quinolinecarboxylic acid antibacterial agents
    19.
    发明授权
    1-Cyclopropyl-1,4-dihydro-4-oxo-7-(4-(2-oxo-1,3-dioxol-4-yl- methyl)-1-piperazinyl)-3-quinolinecarboxylic acid antibacterial agents 失效
    1-环丙基-1,4-二氢-4-氧代-7-（4-（2-氧代-1,3-二氧杂环戊烯-4-基 - 甲基）-1-哌嗪基）-3-喹啉羧酸抗菌剂

    公开(公告)号：US4703047A

    公开(公告)日：1987-10-27

    申请号：US822714

    申请日：1986-01-27

    申请人： Uwe Petersen ,  Klaus Grohe ,  Hans-Joachim Zeiler ,  Karl G. Metzger

    发明人： Uwe Petersen ,  Klaus Grohe ,  Hans-Joachim Zeiler ,  Karl G. Metzger

    IPC分类号： A61K31/495 ,  A61P31/04 ,  A61P33/02 ,  C07D215/56 ,  C07D317/00 ,  C07D333/00 ,  C07D401/04 ,  C07D405/12 ,  C07D405/14 ,  C07D409/14

    CPC分类号： C07D215/56 ,  C07D401/04 ,  C07D405/12 ,  C07D405/14 ,  C07D409/14

    摘要： Novel antibacterially active 1-cyclopropyl-1,4-dihydro-4-oxo-7-[4-(2-oxo-1,3-dioxol-4-yl-methyl)-1-piperazinyl]-3-quinolinecarboxyic acids of the formula in which ##STR1## R is hydrogen or, together with R.sup.1, forms an alkylene radical with 2 or 3 carbon atoms,R.sup.1 is hydrogen, alkyl with 1 to 4 carbon atom or phenyl,R.sup.2 and R.sup.3 each independently is hydrogen, methyl, ethyl, cyclohexyl, methylene-dioxphenyl, furyl, tetrahydrofuryl or thienyl; or phenyl which is optionally mono-, di or tri-substituted by fluorine, chlorine, bromine, methyl, phenyl, cyano, hydroxyl, ethoxy, benzyloxy, amino, methylamino, dimethylamino, piperidino or nitro,X.sup.1 is hydrogen, halogen, or nitro, andX.sup.2 is hydrogen or halogen,or pharmaceutically acceptable hydrates, acid addition salts, alkali metal salts or alkaline earth metal salts thereof.

    摘要翻译： 新型抗菌活性1-环丙基-1,4-二氢-4-氧代-7- [4-（2-氧代-1,3-二氧杂环戊烯-4-基 - 甲基）-1-哌嗪基] -3-喹啉羧酸 其中 R是氢或与R1一起形成具有2或3个碳原子的亚烷基的式，R 1是氢，具有1至4个碳原子的烷基或苯基，R 2和R 3各自独立地是氢，甲基 乙基，环己基，亚甲基二氧苯基，呋喃基，四氢呋喃基或噻吩基; 或苯基，其任选被氟，氯，溴，甲基，苯基，氰基，羟基，乙氧基，苄氧基，氨基，甲基氨基，二甲基氨基，哌啶子基或硝基单，二或三取代，X 1为氢，卤素或硝基 ，X2为氢或卤素，或其药学上可接受的水合物，酸加成盐，碱金属盐或碱土金属盐。

    7-(1-Pyrrolidinyl)-quinolonecarboxylic acid derivatives
    20.
    发明授权
    7-(1-Pyrrolidinyl)-quinolonecarboxylic acid derivatives 失效
    7-（1-吡咯烷基） - 喹诺酮羧酸衍生物

    公开(公告)号：US5153204A

    公开(公告)日：1992-10-06

    申请号：US529696

    申请日：1990-05-29

    申请人： Uwe Petersen ,  Klaus Grohe ,  Hans-Joachim Zeiler ,  Karl G. Metzger

    发明人： Uwe Petersen ,  Klaus Grohe ,  Hans-Joachim Zeiler ,  Karl G. Metzger

    IPC分类号： C07D215/56 ,  C07D401/04 ,  C07D471/04

    CPC分类号： C07D215/56 ,  C07D401/04 ,  C07D471/04

    摘要： 7-(1-Pyrrolidinyl)-3-quinolonecarboxylic acid derivatives of the formula ##STR1## in which A is CH, CCl, CF or N,R.sup.1 is hydroxyl, hydroymethyl or mercapto andR.sup.2 is hydrogen, alkyl, having 1 to 4 carbon atoms or (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl,with the proviso that, when R.sup.1 is hydroxyl, A is not CF or N, or pharmaceutically acceptable hydrates, or salts thereof, are useful as antibacterials and animal feed utilization promoters.

    摘要翻译： 其中A是CH，CCl，CF或N，R 1是羟基，氢化甲基或巯基，R 2是氢，具有1至4个碳的烷基，其中A是CH，CCl，CF或N， 原子或（5-甲基-2-氧代-1,3-二氧杂环戊烯-4-基）甲基，条件是当R 1是羟基时，A不是CF或N，或其药学上可接受的水合物或其盐 用作抗菌剂和动物饲料利用促进剂。