公开(公告)号：US09872853B2

公开(公告)日：2018-01-23

申请号：US15609115

申请日：2017-05-31

申请人： Eli Lilly and Company

发明人： Jolie Anne Bastian ,  Jiehao Chen ,  Jeffrey Daniel Cohen ,  James Robert Henry ,  William Thomas McMillen ,  Bradley Earl Reaman ,  Almudena Rubio ,  Daniel Jon Sall ,  Gaiying Zhao

IPC分类号： A61K31/403 ,  C07D209/12 ,  C07D209/02 ,  C07C233/57 ,  C07C233/01 ,  C07D309/00

CPC分类号： A61K31/403 ,  C07C233/01 ,  C07C233/57 ,  C07D209/02 ,  C07D309/00 ,  C07D405/06

摘要： The present invention relates to certain novel 2,3-dihydro-1H-indole compounds, pharmaceutical compositions comprising the compounds, and methods of using the compounds to treat cancer, more particularly for the treatment of cancer selected from the group consisting of melanoma, acute myeloid leukemia, chronic lymphocytic leukemia, colorectal cancer, breast cancer, lung cancer, ovarian cancer, fallopian tube carcinoma, primary peritoneal carcinoma, cervical cancer, gastric cancer, liver cancer, pancreatic cancer, thyroid cancer, glioma, non-Hodgkin's lymphoma, and Hodgkin's lymphoma.