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公开(公告)号：US10344018B2
公开(公告)日：2019-07-09
申请号：US16273706
申请日：2019-02-12
IPC分类号： C07D403/12 , C07D401/14 , A61K31/4184 , A61P1/00 , A61P37/00 , C07D403/14 , A61K31/4439 , A61P19/02
摘要： The present invention provides compounds of the formula below (I′): where R, and R1-R3 are as described herein, methods of treating patients for certain types of autoimmune diseases and cancer, and processes for preparing the compounds.
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公开(公告)号：US20190177300A1
公开(公告)日：2019-06-13
申请号：US16273706
申请日：2019-02-12
发明人： Jolie Anne Bastian , Joshua Ryan Clayton , David Andrew Coates , Daniel Jon Sall , Timothy Andrew Woods
IPC分类号： C07D401/14 , A61K31/4184 , A61P1/00 , A61P19/02 , C07D403/14 , A61K31/4439 , C07D403/12 , A61P37/00
CPC分类号： C07D401/14 , A61K31/4184 , A61K31/4439 , A61P1/00 , A61P19/02 , A61P37/00 , C07D403/12 , C07D403/14
摘要： The present invention provides compounds of the formula below (I′): where R, and R1-R3 are as described herein, methods of treating patients for certain types of autoimmune diseases and cancer, and processes for preparing the compounds.
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公开(公告)号：US20180325873A1
公开(公告)日：2018-11-15
申请号：US15775990
申请日：2017-07-10
发明人： Jolie Anne Bastian , Joshua Ryan Clayton , David Andrew Coates , Daniel Jon Sall , Timothy Andrew Woods
IPC分类号： A61K31/4184 , A61K31/4439 , A61P1/00 , A61P19/02 , A61P37/00
CPC分类号： A61K31/4184 , A61K31/4439 , A61P1/00 , A61P19/02 , A61P37/00 , C07D403/12
摘要： The present invention provides compounds of the formula below (I′): where R, and R1-R3 are as described herein, methods of treating patients for certain types of autoimmune diseases and cancer, and processes for preparing the compounds.
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公开(公告)号：US11634426B2
公开(公告)日：2023-04-25
申请号：US17465066
申请日：2021-09-02
发明人： Jolie Anne Bastian , Jeffrey Daniel Cohen , Almudena Rubio , Daniel Jon Sall , Jennifer Anne McMahon
IPC分类号： C07D491/052 , A61P35/00 , A61K45/06
摘要： Novel selective estrogen receptor degraders (SERDs) according to the formula: pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, wherein either R1 or R2 is independently selected from Cl, F, —CF3, or —CH3, and the other is hydrogen, and methods for their use are provided.
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公开(公告)号：US11993608B2
公开(公告)日：2024-05-28
申请号：US18121667
申请日：2023-03-15
发明人： Jolie Anne Bastian , Jeffrey Daniel Cohen , Almudena Rubio , Daniel Jon Sall , Jennifer Anne Mcmahon
IPC分类号： C07D491/052 , A61K9/00 , A61K31/4709 , A61P35/00 , C07D401/12 , A61K45/06
CPC分类号： C07D491/052 , A61K9/0053 , A61K31/4709 , A61P35/00 , C07D401/12 , A61K45/06
摘要： Novel selective estrogen receptor degraders (SERDs) according to the formula:
pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, wherein either R1 or R2 is independently selected from Cl, F, —CF3, or —CH3, and the other is hydrogen, and methods for their use are provided.-
公开(公告)号：US10759786B2
公开(公告)日：2020-09-01
申请号：US16307612
申请日：2017-05-31
发明人： Jolie Anne Bastian , Jiehao Chen , Jeffrey Daniel Cohen , James Robert Henry , William Thomas McMillen , Bradley Earl Reaman , Almudena Rubio , Daniel Jon Sall , Gaiying Zhao
IPC分类号： A61K31/03 , C07D209/12 , C07D405/06 , A61P35/02 , A61K31/403 , C07C233/57 , C07D209/02 , C07C233/01 , C07D309/00
摘要： The present invention relates to certain novel 2,3-dihydro-1H-indole compounds, pharmaceutical compositions comprising the compounds, and methods of using the compounds to treat cancer, more particularly for the treatment of cancer selected from the group consisting of melanoma, acute myeloid leukemia, chronic lymphocytic leukemia, colorectal cancer, breast cancer, lung cancer, ovarian cancer, fallopian tube carcinoma, primary peritoneal carcinoma, cervical cancer, gastric cancer, liver cancer, pancreatic cancer, thyroid cancer, glioblastoma, non-Hodgkin's lymphoma, and Hodgkin's lymphoma.
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公开(公告)号：US20170354641A1
公开(公告)日：2017-12-14
申请号：US15609115
申请日：2017-05-31
发明人： Jolie Anne Bastian , Jiehao Chen , Jeffrey Daniel Cohen , James Robert Henry , William Thomas McMillen , Bradley Earl Reaman , Almudena Rubio , Daniel Jon Sall , Gaiying Zhao
IPC分类号： A61K31/403 , C07C233/57 , C07D209/02 , C07C233/01 , C07D309/00
CPC分类号： A61K31/403 , C07C233/01 , C07C233/57 , C07D209/02 , C07D309/00 , C07D405/06
摘要： The present invention relates to certain novel 2,3-dihydro-1H-indole compounds, pharmaceutical compositions comprising the compounds, and methods of using the compounds to treat cancer, more particularly for the treatment of cancer selected from the group consisting of melanoma, acute myeloid leukemia, chronic lymphocytic leukemia, colorectal cancer, breast cancer, lung cancer, ovarian cancer, fallopian tube carcinoma, primary peritoneal carcinoma, cervical cancer, gastric cancer, liver cancer, pancreatic cancer, thyroid cancer, glioma, non-Hodgkin's lymphoma, and Hodgkin's lymphoma.
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公开(公告)号：US11117902B2
公开(公告)日：2021-09-14
申请号：US16876819
申请日：2020-05-18
发明人： Jolie Anne Bastian , Jeffrey Daniel Cohen , Almudena Rubio , Daniel Jon Sall , Jennifer Anne McMahon
IPC分类号： C07D491/052 , A61P35/00 , A61K45/06
摘要： Novel selective estrogen receptor degraders (SERDs) according to the formula: pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, wherein either R1 or R2 is independently selected from Cl, F, —CF3, or —CH3, and the other is hydrogen, and methods for their use are provided.
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公开(公告)号：US10654866B2
公开(公告)日：2020-05-19
申请号：US16508745
申请日：2019-07-11
IPC分类号： C07D491/052 , A61P35/00 , A61K45/06
摘要： Novel selective estrogen receptor degraders (SERDs) according to the formula: pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, wherein either R1 or R2 is independently selected from Cl, F, —CF3, or —CH3, and the other is hydrogen, and methods for their use are provided.
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公开(公告)号：US10323019B2
公开(公告)日：2019-06-18
申请号：US15775990
申请日：2017-07-10
发明人： Jolie Anne Bastian , Joshua Ryan Clayton , David Andrew Coates , Daniel Jon Sall , Timothy Andrew Woods
IPC分类号： C07D401/14 , C07D403/14 , A61K31/4184 , A61K31/4439 , A61P37/00 , A61P19/02 , A61P1/00 , C07D403/12
摘要： The present invention provides compounds of the formula below (I′): where R, and R1-R3 are as described herein, methods of treating patients for certain types of autoimmune diseases and cancer, and processes for preparing the compounds.
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