专利检索 ipc:"C07D209/02" 第 1 页

1.

发明授权
Bisamide sarcomere activating compounds and uses thereof 有权

公开(公告)号：US11299479B1

公开(公告)日：2022-04-12

申请号：US17068518

申请日：2020-10-12

申请人： AMGEN INC. , CYTOKINETICS, INC.

发明人： Luke Ashcraft , Alessandro Boezio , John Butler , Aroop Chandra , Chihyuan Chuang , Scott E. Collibee , Mikkel V. Debenedetto , Vincent DiMassa , Russell Graceffa , Justin Malinowski , David Moebius , Bradley Paul Morgan , Joshua Payette , Antonio Romero , David St. Jean, Jr. , Richard Vargas , John Yeoman , Hanmo Zhang , Alan Cheng , Felix Gonzalez Lopez De Turiso , Michael Garrett Johnson

IPC分类号： C07D403/12 , C07D401/14 , C07D401/12 , A61P9/00 , C07D413/14 , C07D207/16 , C07D413/12 , C07D405/12 , C07D417/14 , C07D401/06 , C07D403/14 , C07D209/02 , C07D209/52

摘要： The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising a compound of the invention, a method for manufacturing compounds of the invention and therapeutic uses thereof.

2.

发明授权
Bisamide sarcomere activating compounds and uses thereof 有权

公开(公告)号：US11254658B2

公开(公告)日：2022-02-22

申请号：US16833321

申请日：2020-03-27

申请人： AMGEN INC. , CYTOKINETICS, INC.

发明人： Mikkel V. Debenedetto , Justin Malinowski , Joshua Payette , Antonio Romero , David St. Jean, Jr.

IPC分类号： C07D403/12 , C07D401/14 , C07D401/12 , A61P9/00 , C07D413/14 , C07D207/16 , C07D209/52 , C07D405/12 , C07D417/14 , C07D401/06 , C07D403/14 , C07D209/02 , C07D413/12

摘要： The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising a compound of the invention, a method for manufacturing compounds of the invention and therapeutic uses thereof.

3.

发明授权
Therapeutic compounds and methods of use thereof 有权

公开(公告)号：US11149002B2

公开(公告)日：2021-10-19

申请号：US16702286

申请日：2019-12-03

申请人： GENENTECH, INC. , XENON PHARMACEUTICALS INC.

发明人： Jean-Christophe Andrez , Philippe Bergeron , Paul Robert Bichler , Sultan Chowdhury , Christoph Martin Dehnhardt , Thilo Focken , Wei Gong , Michael Edward Grimwood , Abid Hasan , Ivan William Hemeon , Qi Jia , Brian Salvatore Safina , Shaoyi Sun , Michael Scott Wilson , Alla Yurevna Zenova

IPC分类号： C07D207/16 , C07D403/12 , C07D413/14 , C07D221/22 , C07D401/12 , C07D413/12 , C07C235/52 , C07D205/04 , C07D277/06 , C07D209/02 , C07D305/08 , C07D401/14 , C07D231/06 , C07D403/04 , C07D403/14 , C07D409/06 , C07D417/12 , C07D451/02 , C07D263/04 , C07D263/26 , C07C235/42 , C07C235/54 , C07D265/30 , C07D207/08 , C07D207/10 , C07D207/22 , C07D209/52 , C07D209/54 , C07D211/20 , C07D211/38 , C07D211/60 , C07D213/69 , C07D401/10 , C07D405/10 , C07D471/08

摘要： The invention provides compounds having the general Formula (I); and pharmaceutically acceptable salts thereof; wherein the variables RA, RAA, subscript n, subscript q, ring A, X2, L, subscript m, X1, R1, R2, R3, R4, R5, D and E have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.

4.

发明申请
PREPARATION AND USE OF (+)-1-(3,4-DICHLOROPHENYL)-3-AZABICYCLO[3.1.0]HEXANE IN THE TREATMENT OF CONDITIONS AFFECTED BY MONOAMINE NEUROTRANSMITTERS 有权

公开(公告)号：US20210161863A1

公开(公告)日：2021-06-03

申请号：US17039064

申请日：2020-09-30

申请人： Anthony Alexander McKinney , Frank Bymaster , Walter Piskorski

发明人： Anthony Alexander McKinney , Frank Bymaster , Walter Piskorski

IPC分类号： A61K31/403 , A61K31/343 , A61K45/06 , C07D209/02 , A61K9/20 , A61K9/48

摘要： The present invention relates to (+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane and pharmaceutically acceptable active salts, polymorphs, glycosylated derivatives, metabolites, solvates, hydrates, and/or prodrugs of (+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane and their use alone or in combination with additional psychotherapeutic compositions in the treatment of conditions affected by monoamine neurotransmitters, including treatment of refractory individuals.

5.

发明申请
BISAMIDE SARCOMERE ACTIVATING COMPOUNDS AND USES THEREOF 审中-公开

公开(公告)号：US20200223830A1

公开(公告)日：2020-07-16

申请号：US16833336

申请日：2020-03-27

申请人： AMGEN INC. , CYTOKINETICS, INC.

发明人： Luke Ashcraft , Alessandro Boezio , John Butler , Aroop Chandra , Chihyuan Chuang , Scott E. Collibee , Mikkel V. Debenedetto , Vincent DiMassa , Russell Graceffa , Justin Malinowski , David Moebius , Bradley Paul Morgan , Joshua Payette , Antonio Romero , David St. Jean, JR. , Richard Vargas , John Yeoman , Hanmo Zhang , Alan Cheng , Felix Gonzalez Lopez De Turiso , Michael Garrett Johnson

IPC分类号： C07D403/12 , C07D401/14 , C07D401/12 , A61P9/00 , C07D413/14 , C07D207/16 , C07D209/52 , C07D405/12 , C07D417/14 , C07D401/06 , C07D403/14 , C07D209/02 , C07D413/12

摘要： The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising a compound of the invention, a method for manufacturing compounds of the invention and therapeutic uses thereof.

6.

发明授权
Therapeutic compounds and methods of use thereof 有权

公开(公告)号：US10526285B2

公开(公告)日：2020-01-07

申请号：US16150070

申请日：2018-10-02

申请人： GENENTECH, INC. , XENON PHARMACEUTICALS INC.

发明人： Jean-Christophe Andrez , Philippe Bergeron , Paul Robert Bichler , Sultan Chowdhury , Christoph Martin Dehnhardt , Thilo Focken , Wei Gong , Michael Edward Grimwood , Abid Hasan , Ivan William Hemeon , Qi Jia , Brian Salvatore Safina , Shaoyi Sun , Michael Scott Wilson , Alla Yurevna Zenova

IPC分类号： C07D207/16 , C07D403/12 , C07D413/14 , C07D221/22 , C07D401/12 , C07D413/12 , C07C235/52 , C07D205/04 , C07D277/06 , C07D209/02 , C07D305/08 , C07D401/14 , C07D231/06 , C07D403/04 , C07D403/14 , C07D409/06 , C07D417/12 , C07D451/02 , C07D263/04 , C07D263/26 , C07C235/42 , C07C235/54 , C07D265/30 , C07D207/08 , C07D207/10 , C07D207/22 , C07D209/52 , C07D209/54 , C07D211/20 , C07D211/38 , C07D211/60 , C07D213/69 , C07D401/10 , C07D405/10 , C07D471/08

摘要： The invention provides compounds having the general Formula (I); and pharmaceutically acceptable salts thereof; wherein the variables RA, RAA, subscript n, subscript q, ring A, X2, L, subscript m, X1, R1, R2, R3, R4, R5, D and E have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.

7.

发明授权
Substituted hexahydropyrrolo[3,4-b]pyrroles and hexahydrocyclopenta[c]pyrroles as dopamine receptor modulators 有权

公开(公告)号：US10273244B2

公开(公告)日：2019-04-30

申请号：US15750128

申请日：2016-08-04

申请人： INDIVIOR UK LIMITED

发明人： Fabrizio Micheli , Susanna Cremonesi , Teresa Semeraro , Luca Tarsi

IPC分类号： A61K31/403 , A61K31/407 , C07D209/02 , C07D487/04 , C07D498/04 , A61P25/36 , A61P25/32 , A61P25/18 , C07D209/52

摘要： The disclosure provides compounds having formula (I), wherein the substituents are as defined herein. The compounds are useful for modulating the dopamine D3 receptor and for treating conditions associated therewith, such as addictions, drug dependency, and psychiatric conditions.

8.

发明授权
2,3-dihydro-1H-indole compounds 有权

公开(公告)号：US09872853B2

公开(公告)日：2018-01-23

申请号：US15609115

申请日：2017-05-31

申请人： Eli Lilly and Company

发明人： Jolie Anne Bastian , Jiehao Chen , Jeffrey Daniel Cohen , James Robert Henry , William Thomas McMillen , Bradley Earl Reaman , Almudena Rubio , Daniel Jon Sall , Gaiying Zhao

IPC分类号： A61K31/403 , C07D209/12 , C07D209/02 , C07C233/57 , C07C233/01 , C07D309/00

CPC分类号： A61K31/403 , C07C233/01 , C07C233/57 , C07D209/02 , C07D309/00 , C07D405/06

摘要： The present invention relates to certain novel 2,3-dihydro-1H-indole compounds, pharmaceutical compositions comprising the compounds, and methods of using the compounds to treat cancer, more particularly for the treatment of cancer selected from the group consisting of melanoma, acute myeloid leukemia, chronic lymphocytic leukemia, colorectal cancer, breast cancer, lung cancer, ovarian cancer, fallopian tube carcinoma, primary peritoneal carcinoma, cervical cancer, gastric cancer, liver cancer, pancreatic cancer, thyroid cancer, glioma, non-Hodgkin's lymphoma, and Hodgkin's lymphoma.

9.

发明授权
Fullerene derivative, and method of preparing the same 有权
标题翻译：富勒烯衍生物及其制备方法

公开(公告)号：US09365513B2

公开(公告)日：2016-06-14

申请号：US14557898

申请日：2014-12-02

申请人： Yoshiki Yanagawa , Ryota Arai

发明人： Yoshiki Yanagawa , Ryota Arai

IPC分类号： C07D209/02 , C07D409/04 , C07D209/52 , C07D409/14 , C07D487/06 , H01L51/00 , H01L51/42

CPC分类号： C07D209/52 , C07D409/04 , C07D409/14 , C07D487/06 , H01L51/0037 , H01L51/0047 , H01L51/0068 , H01L51/0072 , H01L51/4253 , Y02E10/549

摘要： A fullerene derivative having 60 or more carbon atoms, includes at least one specific structure.

摘要翻译： 具有60个或更多碳原子的富勒烯衍生物包括至少一个特定结构。