公开(公告)号：US09394283B2

公开(公告)日：2016-07-19

申请号：US14394431

申请日：2013-04-11

Applicant: EPIZYME, INC. ,  EISAI R&D MANAGEMENT CO., LTD.

Inventor： Kevin Wayne Kuntz ,  Kuan-Chun Huang ,  Hyeong Wook Choi ,  Kristen Sanders ,  Steven Mathieu ,  Arani Chanda ,  Frances Fang

IPC: C07D405/12

CPC classification number: A61K31/5377 ,  C07D405/12

Abstract: Provided herein is N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-4-methyl-4′-(morpholinomethyl)-[1,1′-biphenyl]-3-carboxamide hydrobromide. Also provided herein is a particular polymorph form of this compound.

Abstract translation: 本文提供的是N - （（4,6-二甲基-2-氧代-1,2-二氢吡啶-3-基）甲基）-5-（乙基（四氢-2H-吡喃-4-基）氨基）-4- 甲基-4' - （吗啉代甲基） - [1,1'-联苯] -3-甲酰胺氢溴酸盐。 本文还提供了该化合物的特定多晶型物。

公开(公告)号：US10407439B2

公开(公告)日：2019-09-10

申请号：US15906401

申请日：2018-02-27

Applicant: Eisai R&D Management Co., Ltd.

Inventor： Francis G. Fang ,  Hyeong-Wook Choi ,  Silvio Campagna ,  Steven Mathieu

IPC: C07D493/22 ,  C07D493/08 ,  C07D493/18 ,  C07B57/00 ,  C07D313/00

Abstract: The present invention relates to stereochemically defined polypropionates and methods for preparing and using the same. The stereochemically defined polypropionates may be useful in the synthesis of natural products and/or natural product-like libraries.

公开(公告)号：US10160768B2

公开(公告)日：2018-12-25

申请号：US15501658

申请日：2015-08-04

Applicant: Eisai R&D Management Co., Ltd.

Inventor： Francis G. Fang ,  Hyeong-Wook Choi ,  Silvio Campagna ,  Steven Mathieu

IPC: C07D493/18 ,  C07D493/22 ,  C07B57/00 ,  C07D313/00 ,  C07D493/08

Abstract: The present invention relates to stereochemically defined polypropionates and methods for preparing and using the same. The stereochemically defined polypropionates may be useful in the synthesis of natural products and/or natural product-like libraries.

公开(公告)号：US10793581B2

公开(公告)日：2020-10-06

申请号：US16521691

申请日：2019-07-25

Applicant: Eisai R&D Management Co., Ltd.

Inventor： Francis G. Fang ,  Hyeong-wook Choi ,  Silvio Campagna ,  Steven Mathieu

IPC: C07D493/22 ,  C07B57/00 ,  C07D313/00 ,  C07D493/08 ,  C07D493/18

Abstract: The present invention relates to stereochemically defined polypropionates and methods for preparing and using the same. The stereochemically defined polypropionates may be useful in the synthesis of natural products and/or natural product-like libraries.