公开(公告)号：US20190315754A1

公开(公告)日：2019-10-17

申请号：US16391882

申请日：2019-04-23

Applicant: Eisai R&D Management Co., Ltd.

Inventor： Wanjun Zheng ,  Xiaojie Zhu ,  Hong Du ,  Maarten Postema ,  Yimin Jiang ,  Jing Li ,  Robert Yu ,  Hyeong-wook Choi ,  Jaemoon Lee ,  Frank Fang ,  Daniel Custar

IPC: C07D487/04 ,  C07D519/00 ,  A61P35/00

Abstract: We provide compounds given by Formula I, which is shown in FIG. 3, or pharmaceutically acceptable salts thereof, as well as formulations thereof and methods of use of those compounds and formulations for treatment of cancer.

公开(公告)号：US10941148B2

公开(公告)日：2021-03-09

申请号：US16391882

申请日：2019-04-23

Applicant: Eisai R&D Management Co., Ltd.

Inventor： Wanjun Zheng ,  Xiaojie Zhu ,  Hong Du ,  Maarten Postema ,  Yimin Jiang ,  Jing Li ,  Robert Yu ,  Hyeong-wook Choi ,  Jaemoon Lee ,  Frank Fang ,  Daniel Custar

IPC: C07D487/04 ,  C07D519/00 ,  A61P35/00

Abstract: We provide compounds given by Formula I, which is shown in FIG. 3, or pharmaceutically acceptable salts thereof, as well as formulations thereof and methods of use of those compounds and formulations for treatment of cancer.

公开(公告)号：US20180305362A1

公开(公告)日：2018-10-25

申请号：US15768668

申请日：2016-10-14

Applicant: Eisai R&D Management Co., Ltd.

Inventor： Wanjun Zheng ,  Xiaojie Zhu ,  Hong Du ,  Maarten Postema ,  Yimin Jiang ,  Jing Li ,  Robert Yu ,  Hyeong-wook Choi ,  Jaemoon Lee ,  Frank Fang ,  Daniel Custar

IPC: C07D487/04 ,  C07D519/00 ,  A61P35/00

CPC classification number: C07D487/04 ,  A61P35/00 ,  C07D519/00

Abstract: We provide compounds given by Formula I, which is shown in FIG. 3, or pharmaceutically acceptable salts thereof, as well as formulations thereof and methods of use of those compounds and formulations for treatment of cancer.

公开(公告)号：US10316040B2

公开(公告)日：2019-06-11

申请号：US15768668

申请日：2016-10-14

Applicant: Eisai R&D Management Co., Ltd.

Inventor： Wanjun Zheng ,  Xiaojie Zhu ,  Hong Du ,  Maarten Postema ,  Yimin Jiang ,  Jing Li ,  Robert Yu ,  Hyeong-wook Choi ,  Jaemoon Lee ,  Frank Fang ,  Daniel Custar

IPC: C07D487/04 ,  C07D519/00 ,  A61P35/00

Abstract: We provide compounds given by Formula I, which is shown in FIG. 3, or pharmaceutically acceptable salts thereof, as well as formulations thereof and methods of use of those compounds and formulations for treatment of cancer.

公开(公告)号：US10040782B2

公开(公告)日：2018-08-07

申请号：US15029848

申请日：2014-10-15

Applicant: Epizyme, Inc. ,  Eisai R&D Management Co., Ltd.

Inventor： Kevin W. Kuntz ,  Hyeong-wook Choi ,  Steven Mathieu ,  Kristen Sanders ,  Arani Chanda

IPC: C07D405/12 ,  A61K31/5377 ,  C07D413/12

Abstract: Provided herein are novel solid forms of N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-4-methyl-4′-(morpholinomethyl)-[1,1′-biphenyl]-3-carboxamide hydrochloride, and related compositions and methods.

公开(公告)号：US11339188B2

公开(公告)日：2022-05-24

申请号：US16781352

申请日：2020-02-04

Applicant: Eisai R&D Management Co., Ltd.

Inventor： Dae-Shik Kim ,  Frank Fang ,  Atsushi Endo ,  Hyeong-wook Choi ,  Ming-Hong Hao ,  Xingfeng Bao ,  Kuan-Chun Huang

IPC: C07H21/02 ,  A61P35/02 ,  A61K31/7084 ,  C07F9/6587 ,  C07H21/00 ,  A61P31/04 ,  A61P37/04

Abstract: Provided herein are compounds useful for the treatment of cancer.

公开(公告)号：US10793581B2

公开(公告)日：2020-10-06

申请号：US16521691

申请日：2019-07-25

Applicant: Eisai R&D Management Co., Ltd.

Inventor： Francis G. Fang ,  Hyeong-wook Choi ,  Silvio Campagna ,  Steven Mathieu

IPC: C07D493/22 ,  C07B57/00 ,  C07D313/00 ,  C07D493/08 ,  C07D493/18

Abstract: The present invention relates to stereochemically defined polypropionates and methods for preparing and using the same. The stereochemically defined polypropionates may be useful in the synthesis of natural products and/or natural product-like libraries.