利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

17 条记录 (耗时 0.037 秒)

    Oxy substituted 4-carboxyamino-2-methyl-1,2,3,4-tetrahydroquinolines
    11.
    发明授权
    Oxy substituted 4-carboxyamino-2-methyl-1,2,3,4-tetrahydroquinolines 失效
    氧取代的4-羧基氨基-2-甲基-1,2,3,4-四氢喹啉

    公开(公告)号：US06362198B1

    公开(公告)日：2002-03-26

    申请号：US09670846

    申请日：2000-09-27

    申请人： Steven W. Goldstein ,  Michael R. Makowski ,  Roger B. Ruggeri ,  Ronald T. Wester

    发明人： Steven W. Goldstein ,  Michael R. Makowski ,  Roger B. Ruggeri ,  Ronald T. Wester

    IPC分类号： A61K3147

    CPC分类号： C07D401/12 ,  C07D215/42

    摘要： Cholesteryl ester transfer protein inhibitors, pharmaceutical compositions containing such inhibitors and the use of such inhibitors to elevate certain plasma lipid levels, including high density lipoprotein-cholesterol and to lower certain other plasma lipid levels, such as LDL-cholesterol and triglycerides and accordingly to treat diseases which are exacerbated by low levels of HDL cholesterol and/or high levels of LDL-cholesterol and triglycerides, such as atherosclerosis and cardiovascular diseases in some mammals, including humans.

    摘要翻译： 胆固醇酯转移蛋白抑制剂，含有这些抑制剂的药物组合物以及这些抑制剂用于提高某些血浆脂质水平（包括高密度脂蛋白胆固醇）并降低某些其他血浆脂质水平的用途，例如LDL-胆固醇和甘油三酯，并因此治疗 HDL胆固醇水平升高和/或LDL-胆固醇和甘油三酯水平升高的疾病，如一些哺乳动物，包括人类的动脉粥样硬化和心血管疾病。

    Angiotensin II receptor antagonists
    13.
    发明授权
    Angiotensin II receptor antagonists 失效
    血管紧张素II受体拮抗剂

    公开(公告)号：US5338740A

    公开(公告)日：1994-08-16

    申请号：US91099

    申请日：1993-07-13

    申请人： Philip C. Carpino ,  Ronald T. Wester ,  Paul A. Da Silva Jardine

    发明人： Philip C. Carpino ,  Ronald T. Wester ,  Paul A. Da Silva Jardine

    IPC分类号： C07D403/10 ,  C07D471/04 ,  A61K31/435

    CPC分类号： C07D403/10 ,  C07D471/04

    摘要： The present invention relates to novel heterocyclic derivatives of the formulaAr--W--Hetwherein Ar, W and Het are as defined below, and related compounds, pharmaceutical compositions comprising such compounds, and the use of such compounds as regulators of the action of angiotensin II in mammals. The compounds of this invention are useful in the treatment and prevention of hypertension, glaucoma, renal disease, congestive heart failure, cognitive dysfunction, and other conditions in which the action of angiotensin II is implicated. This invention also relates to pharmaceutical compositions containing these compounds and to methods of inhibiting angiotensin II in mammals by administration of such compounds.

    摘要翻译： 本发明涉及式Ar-W-Het的新型杂环衍生物，其中Ar，W和Het定义如下，相关化合物，包含这些化合物的药物组合物，以及这些化合物作为血管紧张素作用调节剂的用途 II在哺乳动物 本发明的化合物可用于治疗和预防高血压，青光眼，肾脏疾病，充血性心力衰竭，认知功能障碍以及涉及血管紧张素II的作用的其它病症。 本发明还涉及含有这些化合物的药物组合物和通过施用这些化合物来抑制哺乳动物血管紧张素II的方法。