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72 条记录 (耗时 0.039 秒)

    Oxy substituted 4-carboxyamino-2-methyl-1,2,3,4-tetrahydroquinolines
    1.
    发明授权
    Oxy substituted 4-carboxyamino-2-methyl-1,2,3,4-tetrahydroquinolines 失效
    氧取代的4-羧基氨基-2-甲基-1,2,3,4-四氢喹啉

    公开(公告)号：US06362198B1

    公开(公告)日：2002-03-26

    申请号：US09670846

    申请日：2000-09-27

    申请人： Steven W. Goldstein ,  Michael R. Makowski ,  Roger B. Ruggeri ,  Ronald T. Wester

    发明人： Steven W. Goldstein ,  Michael R. Makowski ,  Roger B. Ruggeri ,  Ronald T. Wester

    IPC分类号： A61K3147

    CPC分类号： C07D401/12 ,  C07D215/42

    摘要： Cholesteryl ester transfer protein inhibitors, pharmaceutical compositions containing such inhibitors and the use of such inhibitors to elevate certain plasma lipid levels, including high density lipoprotein-cholesterol and to lower certain other plasma lipid levels, such as LDL-cholesterol and triglycerides and accordingly to treat diseases which are exacerbated by low levels of HDL cholesterol and/or high levels of LDL-cholesterol and triglycerides, such as atherosclerosis and cardiovascular diseases in some mammals, including humans.

    摘要翻译： 胆固醇酯转移蛋白抑制剂，含有这些抑制剂的药物组合物以及这些抑制剂用于提高某些血浆脂质水平（包括高密度脂蛋白胆固醇）并降低某些其他血浆脂质水平的用途，例如LDL-胆固醇和甘油三酯，并因此治疗 HDL胆固醇水平升高和/或LDL-胆固醇和甘油三酯水平升高的疾病，如一些哺乳动物，包括人类的动脉粥样硬化和心血管疾病。

    Wearable device for reducing exposure to pathogens of possible contagion
    3.
    发明授权
    Wearable device for reducing exposure to pathogens of possible contagion 有权

    公开(公告)号：US11328823B2

    公开(公告)日：2022-05-10

    申请号：US16949088

    申请日：2020-10-13

    申请人： Steven W. Goldstein

    发明人： Steven W. Goldstein

    IPC分类号： G16H50/30 ,  A61B5/00 ,  A61B5/117 ,  G16H50/20 ,  G06N20/00 ,  G16H50/80

    摘要： A wearable device for reducing exposure to pathogens of possible contagion includes a detection component configured to detect a proximate subject in relation to a user wherein the user is in possession of the wearable device, a data input component configured to capture data relating to the proximate subject, wherein the data relating to the currently proximate subject further comprises an inoculation status of the currently proximate subject, a processor configured to calculate a degree of transmission threat between the user and the proximate subject, wherein calculating the degree of transmission threat further comprises identifying a pathogen of possible contagion, locating a reproduction rate for the pathogen of possible contagion, calculating the degree of transmission threat as a function of the data input component and the reproduction rate, and a user-signaling component configured to generate an output as a function of the degree of transmission threat.

    SOUND LEVEL DOSEAGE SYSTEM FOR VEHICLES
    5.
    发明申请
    SOUND LEVEL DOSEAGE SYSTEM FOR VEHICLES 有权
    声级系统

    公开(公告)号：US20140010380A1

    公开(公告)日：2014-01-09

    申请号：US13979005

    申请日：2012-01-12

    申请人： John Usher ,  Steven W. Goldstein

    发明人： John Usher ,  Steven W. Goldstein

    IPC分类号： H04R29/00

    CPC分类号： H04R29/00 ,  H03G3/3005 ,  H03G3/3089 ,  H03G3/32

    摘要： Audio systems for a vehicle and methods of operating an audio device in a vehicle cabin are provided. A method of operating an audio device directs an acoustic signal to at least one vehicle cabin receiver (VCR) of the audio device; measures sound pressure levels (SPLVCM) for acoustic energy received by at least one vehicle cabin microphone (VCM) of the audio device during a time period Δt; calculates a sound pressure level (SPL) dose (SPL_DoseΔt) during the time period Δt using the sound pressure levels SPLVCM of the at least one VCM; combines the SPL dose (SPL_DoseΔt) with an SPL dose of a previous time period to form a total SPL dose (SPL_Dosetotal); and performs an action to modify operation of the audio device when the total SPL dose is greater than a predetermined threshold.

    摘要翻译： 提供了用于车辆的音频系统以及在车厢中操作音频设备的方法。 操作音频设备的方法将声信号引导到音频设备的至少一个车厢接收器（VCR）; 测量在一段时间内由音频设备的至少一个车厢麦克风（VCM）接收的声能的声压级（SPLVCM）; 使用所述至少一个VCM的声压级SPLVCM在所述时间段Deltat期间计算声压级（SPL_DoseDeltat）; 将SPL剂量（SPL_DoseDeltat）与前一时间段的SPL剂量组合以形成总SPL剂量（SPL-糖值）; 并且当总SPL剂量大于预定阈值时，执行修改音频设备的操作的动作。

    EARHEALTH MONITORING SYSTEM AND METHOD I
    6.
    发明申请
    EARHEALTH MONITORING SYSTEM AND METHOD I 有权
    神经监测系统和方法I

    公开(公告)号：US20080212787A1

    公开(公告)日：2008-09-04

    申请号：US11928290

    申请日：2007-10-30

    申请人： Steven W. Goldstein ,  John Usher ,  Brian Fligor ,  John P. Keady

    发明人： Steven W. Goldstein ,  John Usher ,  Brian Fligor ,  John P. Keady

    IPC分类号： H04R29/00

    CPC分类号： A61B5/6817 ,  A61B5/121 ,  G01H3/14

    摘要： At least one exemplary embodiment is directed to a method of operating an audio device comprising: calculating estimated sound pressure levels for drive signals directed to an ear canal receiver (ECR) during a time increment Δt; calculating an estimated SPL_Dose during the time increment Δt using the estimated sound pressure levels; and calculating a total SPL_Dose at the time t of the audio device using the estimated SPL_Dose.

    摘要翻译： 至少一个示例性实施例涉及一种操作音频设备的方法，包括：在时间增量Deltat期间计算针对耳道接收器（ECR）的驱动信号的估计声压级; 在使用估计声压级的时间增量Deltat期间计算估计的SPL_Dose; 以及使用所估计的SPL_Dose在音频设备的时间t计算总SPL_Dose。

    EARHEALTH MONITORING SYSTEM AND METHOD III
    7.
    发明申请
    EARHEALTH MONITORING SYSTEM AND METHOD III 有权
    神经监测系统及方法III

    公开(公告)号：US20080144841A1

    公开(公告)日：2008-06-19

    申请号：US11930938

    申请日：2007-10-31

    申请人： Steven W. Goldstein ,  John Usher ,  Brian Fligor ,  John P. Keady

    发明人： Steven W. Goldstein ,  John Usher ,  Brian Fligor ,  John P. Keady

    IPC分类号： H04R29/00

    CPC分类号： G01H3/14

    摘要： A system for monitoring sound pressure levels at the ear includes an ambient sound microphone for receiving ambient sounds and an ear canal microphone for producing audio signals as a function of ambient sound received at the ambient sound microphone and sound signal received from an associated personal audio device. A logic circuit is operatively associated with the ASM and ECR calculates a total SPL_Dose experienced by the ear at a time t. In one exemplary embodiment the total SPL_Dose is calculated by determining estimated SPL_Dose for periods Δt. The logic circuit then may then select an action parameter in response to the Total SPL_Dose.

    摘要翻译： 用于监测耳朵的声压级的系统包括用于接收环境声音的环境声麦克风和用于产生作为在环境声音麦克风​​处接收的环境声音和从相关联的个人音频设备接收的声音信号的函数的音频信号的耳道麦克风 。 逻辑电路与ASM可操作地相关联，并且ECR在时间t计算耳朵经历的总SPL_Dose。 在一个示例性实施例中，通过确定周期Deltat的估计SPL_Dose来计算总SPL_Dose。 然后逻辑电路可以响应于总SPL_Dose来选择动作参数。

    Hypoglycemic hydroxyurea derivatives
    10.
    发明授权
    Hypoglycemic hydroxyurea derivatives 失效
    低血糖羟基脲衍生物

    公开(公告)号：US5334604A

    公开(公告)日：1994-08-02

    申请号：US983538

    申请日：1993-02-22

    申请人： Steven W. Goldstein ,  Ruth E. McDermott

    发明人： Steven W. Goldstein ,  Ruth E. McDermott

    IPC分类号： A61K31/42 ,  A61K31/421 ,  A61P3/06 ,  A61P3/08 ,  C07D20060101 ,  C07D213/12 ,  C07D213/14 ,  C07D263/32 ,  C07D263/34 ,  C07D263/38 ,  C07D413/04 ,  C07D413/06 ,  C07D413/12 ,  C07D413/14 ,  C07D413/00

    CPC分类号： C07D413/04 ,  C07D263/32 ,  C07D413/10 ,  C07D413/12 ,  C07D413/14

    摘要： There are disclosed preparative processes and hypoglycemic compounds of the formula ##STR1## wherein R is hydrogen or C1 to C3 alkyl;R.sup.1 and R.sup.2 are taken together and are carbonyl; or R.sup.1 and R.sup.2 are taken separately, wherein R.sup.1 is hydrogen or R.sup.4 and R.sup.2 is--COR.sup.5 and COOR.sup.5 ;R.sup.3, R.sup.4 and R.sup.5 are each independently C1 to C9 alkyl, C3 to C7 cycloalkyl, phenyl, naphthyl, furyl, benzofuryl or thienyl or one of said groups mono- or disubstituted with C1 to C3 alkyl, C1 to C3 alkoxy, C1 to C3 alkoxy-carbonyl, trifluoromethyl, fluoro or chloro; and n is 0 or 1; or pharmaceutically acceptable cationic salts thereof.

    摘要翻译： PCT No.PCT / US91 / 04352 Sec。 371日期：1993年2月22日 102（e）日期1993年2月22日PCT 1991年6月26日PCT公开。公开了制备方法和式“IMAGE”的降血糖化合物，其中R是氢或C 1至C 3烷基; R 1和R 2一起并且是羰基; 或R1和R2分别取代，其中R1是氢或R4，R2是-Co5和COOR5; R 3，R 4和R 5各自独立地为C 1至C 9烷基，C 3至C 7环烷基，苯基，萘基，呋喃基，苯并呋喃基或噻吩基或被C1至C3烷基，C1至C3烷氧基，C1至C3单取代或二取代的一个基团 烷氧羰基，三氟甲基，氟或氯; 并且n为0或1; 或其药学上可接受的阳离子盐。