公开(公告)号：US20230374024A1

公开(公告)日：2023-11-23

申请号：US18334113

申请日：2023-06-13

Applicant: Exelixis, Inc.

Inventor： Lynne Canne Bannen ,  Minna Bui ,  Faming Jiang ,  Yong Wang ,  Wei Xu

IPC: C07D487/04 ,  C07D239/88 ,  C07D403/04 ,  C07D403/12 ,  C07D405/12

CPC classification number: C07D487/04 ,  C07D239/88 ,  C07D403/04 ,  C07D403/12 ,  C07D405/12

Abstract: Disclosed herein are compounds of Formula (I′). Compounds of Formula (I′) inhibit, regulate and/or modulate kinase receptor, particularly Axl and Mer signal transduction pathways related to the changes in cellular activities as mentioned above, compositions which contain these compounds, and methods of using them to treat kinase-dependent diseases and conditions. The present invention also provides methods for making compounds as mentioned above, and compositions which contain these compounds.

公开(公告)号：US20230151003A1

公开(公告)日：2023-05-18

申请号：US17800084

申请日：2021-02-23

Applicant: Exelixis, Inc.

Inventor： Lynne Bannen ,  Wei Xu ,  Yong Wang ,  Andrew Raub ,  Benjamin Spangler ,  Justin Salvant ,  Kin Tso ,  Faming Jiang

IPC: C07D471/04 ,  C07D401/12 ,  C07D519/00

CPC classification number: C07D471/04 ,  C07D401/12 ,  C07D519/00

Abstract: The present disclosure relates generally to compounds and pharmaceutical compositions suitable as modulators of protein kinases, and methods for their use in treating disorders mediated, at least in part by, protein kinases.

公开(公告)号：US11542259B2

公开(公告)日：2023-01-03

申请号：US16964330

申请日：2019-01-25

Applicant: Exelixis, Inc.

Inventor： Lynne Canne Bannen ,  Minna Bui ,  Faming Jiang ,  Kin Tso ,  Yong Wang ,  Wei Xu

IPC: C07D413/12 ,  C07D215/22 ,  C07D401/12 ,  C07D405/12 ,  C07D413/10 ,  C07D498/04

Abstract: Disclosed herein are compounds of formula I. Compounds of formula I inhibit, regulate and/or modulate kinase receptor, particularly Axl and Mer signal transduction pathways related to the changes in cellular activities as mentioned above, compositions which contain these compounds, and methods of using them to treat kinase-dependent diseases and conditions. The present invention also provides methods for making compounds as mentioned above, and compositions which contain these compounds.