公开(公告)号：US20230043835A1

公开(公告)日：2023-02-09

申请号：US17616120

申请日：2020-06-03

Applicant: Exelixis, Inc.

Inventor： Lynne Canne Bannen ,  Minna Bui ,  Faming Jiang ,  Kin Tso ,  Yong Wang ,  Wei Xu

IPC: C07D215/233 ,  C07D401/04 ,  C07D407/04 ,  C07D401/14 ,  C07D417/04 ,  C07D413/04 ,  C07D471/04

Abstract: Disclosed herein are compounds of Formula (I) which inhibit, regulate and/or modulate tyrosine kinase receptors, particularly Ax1 and Mer signal transduction pathways related to the changes in cellular activities, compositions containing the compounds, methods of using the compounds to treat kinase-dependent diseases and conditions, and methods for making the compounds.

公开(公告)号：US11673897B2

公开(公告)日：2023-06-13

申请号：US16964274

申请日：2019-01-25

Applicant: Exelixis, Inc.

Inventor： Lynne Canne Bannen ,  Minna Bui ,  Faming Jiang ,  Yong Wang ,  Wei Xu

IPC: C07D401/12 ,  C07D401/14 ,  C07D413/14 ,  C07D491/147 ,  C07D471/04

CPC classification number: C07D491/147 ,  C07D401/12 ,  C07D401/14 ,  C07D413/14 ,  C07D471/04

Abstract: Disclosed herein are compounds of Formula I′. Compounds of Formula I′ inhibit, regulate and/or modulate kinase receptor, particularly Axl and Mer signal transduction pathways related to the changes in cellular activities as mentioned above, compositions which contain these compounds, and methods of using them to treat kinase-dependent diseases and conditions. The present invention also provides methods for making compounds as mentioned above, and compositions which contain these compounds.

公开(公告)号：US20210032263A1

公开(公告)日：2021-02-04

申请号：US16964274

申请日：2019-01-25

Applicant: Exelixis, Inc.

Inventor： Lynne Canne Bannen ,  Minna Bui ,  Faming Jiang ,  Yong Wang ,  Wei Xu

IPC: C07D491/147 ,  C07D401/12 ,  C07D413/14 ,  C07D401/14 ,  C07D471/04

Abstract: Disclosed herein are compounds of Formula I′. Compounds of Formula I′ inhibit, regulate and/or modulate kinase receptor, particularly Axl and Mer signal transduction pathways related to the changes in cellular activities as mentioned above, compositions which contain these compounds, and methods of using them to treat kinase-dependent diseases and conditions. The present invention also provides methods for making compounds as mentioned above, and compositions which contain these compounds.

公开(公告)号：US12195475B2

公开(公告)日：2025-01-14

申请号：US18334113

申请日：2023-06-13

Applicant: Exelixis, Inc.

Inventor： Lynne Canne Bannen ,  Minna Bui ,  Faming Jiang ,  Yong Wang ,  Wei Xu

IPC: C07D487/04 ,  C07D239/88 ,  C07D403/04 ,  C07D403/12 ,  C07D405/12

Abstract: Disclosed herein are compounds of Formula (I′). Compounds of Formula (I′) inhibit, regulate and/or modulate kinase receptor, particularly Axl and Mer signal transduction pathways related to the changes in cellular activities as mentioned above, compositions which contain these compounds, and methods of using them to treat kinase-dependent diseases and conditions. The present invention also provides methods for making compounds as mentioned above, and compositions which contain these compounds.

公开(公告)号：US11708367B2

公开(公告)日：2023-07-25

申请号：US16964228

申请日：2019-01-25

Applicant: Exelixis, Inc.

Inventor： Lynne Canne Bannen ,  Minna Bui ,  Faming Jiang ,  Yong Wang ,  Wei Xu

IPC: C07D487/04 ,  C07D239/88 ,  C07D403/04 ,  C07D403/12 ,  C07D405/12

CPC classification number: C07D487/04 ,  C07D239/88 ,  C07D403/04 ,  C07D403/12 ,  C07D405/12

Abstract: Disclosed herein are compounds of Formula (I′). Compounds of Formula (I′) inhibit, regulate and/or modulate kinase receptor, particularly Axl and Mer signal transduction pathways related to the changes in cellular activities as mentioned above, compositions which contain these compounds, and methods of using them to treat kinase-dependent diseases and conditions. The present invention also provides methods for making compounds as mentioned above, and compositions which contain these compounds.

公开(公告)号：US20220315579A1

公开(公告)日：2022-10-06

申请号：US17033475

申请日：2020-09-25

Applicant: Exelixis, Inc.

Inventor： Lynne Bannen ,  Minna Bui ,  Faming Jiang ,  Jack Maung ,  Andrew Raub ,  Justin Salvant ,  Benjamin Spangler ,  Kin Tso ,  Yong Wang ,  Wei Xu

IPC: C07D471/04

Abstract: The present disclosure relates generally to compounds and pharmaceutical compositions suitable as modulators of protein kinases, and methods for their use in treating disorders mediated, at least in part by, protein kinases.

公开(公告)号：US20220089541A1

公开(公告)日：2022-03-24

申请号：US17425661

申请日：2020-01-24

Applicant: Exelixis, Inc.

Inventor： Lynne Canne Bannen ,  Faming Jiang ,  Kin Tso ,  Xu Wei

IPC: C07D215/22 ,  C07D215/48 ,  C07D401/12 ,  C07D471/04 ,  A61P35/00

Abstract: The present invention relates to compounds that modulate cellular activities such as proliferation, differentiation, programmed cell death, migration, and chemoinvasion, by modulating protein kinase enzymatic activity, and compositions thereof, and methods of using such compounds.

公开(公告)号：US20240150371A1

公开(公告)日：2024-05-09

申请号：US18132124

申请日：2023-04-07

Applicant: Exelixis, Inc.

Inventor： Lynne Canne Bannen ,  Minna Bui ,  Faming Jiang ,  Yong Wang ,  Wei Xu

IPC: C07D491/147 ,  C07D401/12 ,  C07D401/14 ,  C07D413/14 ,  C07D471/04

CPC classification number: C07D491/147 ,  C07D401/12 ,  C07D401/14 ,  C07D413/14 ,  C07D471/04

Abstract: Disclosed herein are compounds of Formula I′. Compounds of Formula I′ inhibit, regulate and/or modulate kinase receptor, particularly Axl and Mer signal transduction pathways related to the changes in cellular activities as mentioned above, compositions which contain these compounds, and methods of using them to treat kinase-dependent diseases and conditions. The present invention also provides methods for making compounds as mentioned above, and compositions which contain these compounds.

公开(公告)号：US20210040076A1

公开(公告)日：2021-02-11

申请号：US16964330

申请日：2019-01-25

Applicant: Exelixis, Inc.

Inventor： Lynne Canne Bannen ,  Minna Bui ,  Faming Jiang ,  Kin Tso ,  Yong Wang ,  Wei Xu

IPC: C07D413/12 ,  C07D215/22 ,  C07D401/12 ,  C07D405/12 ,  C07D413/10 ,  C07D498/04

Abstract: Disclosed herein are compounds of formula I. Compounds of formula I inhibit, regulate and/or modulate kinase receptor, particularly Axl and Mer signal transduction pathways related to the changes in cellular activities as mentioned above, compositions which contain these compounds, and methods of using them to treat kinase-dependent diseases and conditions. The present invention also provides methods for making compounds as mentioned above, and compositions which contain these compounds.

公开(公告)号：US20240043414A1

公开(公告)日：2024-02-08

申请号：US17989393

申请日：2022-11-17

Applicant: Exelixis, Inc.

Inventor： Lynne Canne Bannen ,  Minna Bui ,  Faming Jiang ,  Kin Tso ,  Yong Wang ,  Wei Xu

IPC: C07D413/12 ,  C07D215/22 ,  C07D401/12 ,  C07D405/12 ,  C07D413/10 ,  C07D498/04

CPC classification number: C07D413/12 ,  C07D215/22 ,  C07D401/12 ,  C07D405/12 ,  C07D413/10 ,  C07D498/04

Abstract: Disclosed herein are compounds of formula I. Compounds of formula I inhibit, regulate and/or modulate kinase receptor, particularly Axl and Mer signal transduction pathways related to the changes in cellular activities as mentioned above, compositions which contain these compounds, and methods of using them to treat kinase-dependent diseases and conditions. The present invention also provides methods for making compounds as mentioned above, and compositions which contain these compounds.