公开(公告)号：US10577329B2

公开(公告)日：2020-03-03

申请号：US16351457

申请日：2019-03-12

Applicant: FORMA Therapeutics, Inc.

Inventor： Jian Lin ,  Anna Ericsson ,  Ann-Marie Campbell ,  Gary Gustafson ,  Zhongguo Wang ,  R. Bruce Diebold ,  Susan Ashwell ,  David R. Lancia, Jr. ,  Justin Andrew Caravella ,  Wei Lu

IPC: C07D215/227 ,  C07D403/12 ,  C07D401/12 ,  C07D405/12 ,  C07D413/12 ,  C07D417/12 ,  C07D487/04 ,  C07D471/04 ,  C07D498/04 ,  C07D401/14 ,  C07D519/00 ,  A61P35/00

Abstract: The invention relates to inhibitors of mutant isocitrate dehydrogenase (mt-IDH) proteins with neomorphic activity useful in the treatment of cell-proliferation disorders and cancers, having the Formula: where A, B, U, V, Z, W1, W2, W3, and R1-R6 are described herein.

公开(公告)号：US10519130B2

公开(公告)日：2019-12-31

申请号：US16179125

申请日：2018-11-02

Applicant: FORMA Therapeutics, Inc.

Inventor： Stephanos Ioannidis ,  Adam Charles Talbot ,  Bruce Follows ,  Alexandre Joseph Buckmelter ,  Minghua Wang ,  Ann-Marie Campbell ,  David R. Lancia, Jr.

IPC: C07D401/06 ,  C07D239/88 ,  C07D487/04 ,  C07D471/04

Abstract: The present disclosure relates to inhibitors of USP7 inhibitors useful in the treatment of cancers, neurodegenerative diseases, immunological disorders, inflammatory disorders, cardiovascular diseases, ischemic diseases, viral infections and diseases, and bacterial infections and diseases, having the Formula: where R1, R2, R3, R4, R4′, X1, Y1, Y2, Y3, Y4, n, and m are described herein.

公开(公告)号：US10513507B2

公开(公告)日：2019-12-24

申请号：US15837393

申请日：2017-12-11

Applicant: FORMA Therapeutics, Inc.

Inventor： Stephanos Ioannidis ,  Adam Charles Talbot ,  Bruce Follows ,  Alexandre Joseph Buckmelter ,  Minghua Wang ,  Ann-Marie Campbell ,  David R. Lancia, Jr.

IPC: C07D401/06 ,  C07D239/88 ,  C07D487/04 ,  C07D471/04

Abstract: The present disclosure relates to inhibitors of USP7 inhibitors useful in the treatment of cancers, neurodegenerative diseases, immunological disorders, inflammatory disorders, cardiovascular diseases, ischemic diseases, viral infections and diseases, and bacterial infections and diseases, having the Formula: where R1, R2, R3, R4, R4′, X1, Y1, Y2, Y3, Y4, n, and m are described herein.

公开(公告)号：US10414752B2

公开(公告)日：2019-09-17

申请号：US15964844

申请日：2018-04-27

Applicant: FORMA Therapeutics, Inc.

Inventor： Jian Lin ,  Anna Ericsson ,  Ann-Marie Campbell ,  Gary Gustafson ,  Zhongguo Wang ,  R. Bruce Diebold ,  Susan Ashwell ,  David R. Lancia, Jr. ,  Justin Andrew Caravella ,  Wei Lu

IPC: C07D401/12 ,  C07D401/14 ,  C07D471/04 ,  A61P35/00 ,  A61K31/47

Abstract: The application relates to an inhibitor of mutant isocitrate dehydrogenase (mt-IDH) proteins with neomorphic activity useful in the treatment of cell-proliferation disorders and cancers, having the Formula (I-13):

公开(公告)号：US10377767B2

公开(公告)日：2019-08-13

申请号：US15909200

申请日：2018-03-01

Applicant: FORMA Therapeutics, Inc.

Inventor： Stephanos Ioannidis ,  Adam Charles Talbot ,  Bruce Follows ,  Alexandre Joseph Buckmelter ,  Minghua Wang ,  Ann-Marie Campbell ,  David R. Lancia, Jr.

IPC: A61K31/519 ,  C07D495/04

Abstract: The disclosure relates to inhibitors of USP7 inhibitors useful in the treatment of cancers, neurodegenerative diseases, immunological disorders, inflammatory disorders, cardiovascular diseases, ischemic diseases, viral infections and diseases, and bacterial infections and diseases, having the Formula: where R1, R2, R3, R5, R5′, X1, X2, n, and m are described herein.

公开(公告)号：US10377760B2

公开(公告)日：2019-08-13

申请号：US15874163

申请日：2018-01-18

Applicant: FORMA Therapeutics, Inc.

Inventor： Stephanos Ioannidis ,  Adam Charles Talbot ,  Bruce Follows ,  Alexandre Joseph Buckmelter ,  Minghua Wang ,  Ann-Marie Campbell ,  Darby Rye Schmidt ,  David Joseph Guerin ,  Justin Andrew Caravella ,  R. Bruce Diebold ,  Anna Ericsson ,  David R. Lancia, Jr.

IPC: C07D487/04 ,  C07D519/00 ,  A61K31/519

Abstract: The invention relates to inhibitors of USP7 inhibitors useful in the treatment of cancers, neurodegenerative diseases, immunological disorders, inflammatory disorders, cardiovascular diseases, ischemic diseases, viral infections and diseases, and bacterial infections and diseases, having the Formula: where m, n, X1, X2, R1-R5, R5 and R6 are described herein.

公开(公告)号：US20190071421A1

公开(公告)日：2019-03-07

申请号：US16179111

申请日：2018-11-02

Applicant: FORMA Therapeutics, Inc.

Inventor： Stephanos Ioannidis ,  Adam Charles Talbot ,  Bruce Follows ,  Alexandre Joseph Buckmelter ,  Minghua Wang ,  Ann-Marie Campbell ,  David R. Lancia, JR.

IPC: C07D401/06 ,  C07D487/04 ,  C07D471/04 ,  C07D239/88

CPC classification number: C07D401/06 ,  C07D239/88 ,  C07D471/04 ,  C07D487/04

Abstract: The present disclosure relates to inhibitors of USP7 inhibitors useful in the treatment of cancers, neurodegenerative diseases, immunological disorders, inflammatory disorders, cardiovascular diseases, ischemic diseases, viral infections and diseases, and bacterial infections and diseases, having the Formula: where R1, R2, R3, R4, R4′, X1, Y1, Y2, Y3, Y4, n, and m are described herein.

公开(公告)号：US20190071420A1

公开(公告)日：2019-03-07

申请号：US16179099

申请日：2018-11-02

Applicant: FORMA Therapeutics, Inc.

Inventor： Stephanos Ioannidis ,  Adam Charles Talbot ,  Bruce Follows ,  Alexandre Joseph Buckmelter ,  Minghua Wang ,  Ann-Marie Campbell ,  David R. Lancia, JR.

IPC: C07D401/06 ,  C07D487/04 ,  C07D471/04 ,  C07D239/88

CPC classification number: C07D401/06 ,  C07D239/88 ,  C07D471/04 ,  C07D487/04

Abstract: The present disclosure relates to inhibitors of USP7 inhibitors useful in the treatment of cancers, neurodegenerative diseases, immunological disorders, inflammatory disorders, cardiovascular diseases, ischemic diseases, viral infections and diseases, and bacterial infections and diseases, having the Formula: where R1, R2, R3, R4, R4′, X1, Y1, Y2, Y3, Y4, n, and m are described herein.

公开(公告)号：US20180339988A1

公开(公告)日：2018-11-29

申请号：US15874163

申请日：2018-01-18

Applicant: FORMA Therapeutics, Inc.

Inventor： Stephanos Ioannidis ,  Adam Charles Talbot ,  Bruce Follows ,  Alexandre Joseph Buckmelter ,  Minghua Wang ,  Ann-Marie Campbell ,  Darby Rye Schmidt ,  David Joseph Guerin ,  Justin Andrew Caravella ,  R. Bruce Diebold ,  Anna Ericsson ,  David R. Lancia, JR.

IPC: C07D487/04 ,  A61K31/519 ,  C07D519/00

CPC classification number: C07D487/04 ,  A61K31/519 ,  C07D519/00

Abstract: The invention relates to inhibitors of USP7 inhibitors useful in the treatment of cancers, neurodegenerative diseases, immunological disorders, inflammatory disorders, cardiovascular diseases, ischemic diseases, viral infections and diseases, and bacterial infections and diseases, having the Formula: where m, n, X1, X2, R1-R5, R5 and R6 are described herein.

公开(公告)号：US20180327361A1

公开(公告)日：2018-11-15

申请号：US15977512

申请日：2018-05-11

Applicant: FORMA Therapeutics, Inc.

Inventor： Jian Lin ,  Anna Ericsson ,  Ann-Marie Campbell ,  Gary Gustafson ,  Zhongguo Wang ,  R. Bruce Diebold ,  Susan Ashwell ,  David R. Lancia, JR. ,  Justin Andrew Caravella ,  Wei Lu

IPC: C07D215/227 ,  A61K31/4709 ,  C07D471/04 ,  C07D405/12 ,  C07D401/12 ,  C07D409/12

CPC classification number: C07D215/227 ,  A61K31/4709 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12 ,  C07D471/04

Abstract: The invention relates to inhibitors of mutant isocitrate dehydrogenase (mt-IDH) proteins with neomorphic activity useful in the treatment of cell-proliferation disorders and cancers, having the Formula: where A, B, W1, W2, W3, and R1-R8 are described herein.