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    N-(aminoindanyl)amides as analgesics and antiarrhythmics
    18.
    发明授权
    N-(aminoindanyl)amides as analgesics and antiarrhythmics 失效
    N-（氨基茚满基）酰胺作为镇痛药和抗心律失常药

    公开(公告)号：US4988727A

    公开(公告)日：1991-01-29

    申请号：US409048

    申请日：1989-09-19

    申请人： Francois Clemence ,  Michel Fortin

    发明人： Francois Clemence ,  Michel Fortin

    IPC分类号： C07D295/135 ,  C07D295/155 ,  C07D333/24 ,  C07D333/54

    CPC分类号： C07D295/135 ,  C07D295/155 ,  C07D333/24 ,  C07D333/54

    摘要： A compound selected from the group consisting of all enantiomeric and diastereoisomeric forms possible of compounds of the formula ##STR1## wherein X is selected from the group consisting of hydrogen, halogen, and alkyl and alkoxy of 1 to 5 carbon atoms, R.sub.1 and R.sub.2 are individually selected from the group consisting of hydrogen and alkyl of 1 to 5 carbon atoms, one of A and B being ##STR2## and the other being ##STR3## R is hydrogen or alkyl of 1 to 5 carbon atoms, Z is --(CH.sub.2).sub.n -- or branched alkylene of 2 to 8 carbon atoms, n is an integer from 0 to 5, Y is selected from the group consisting of naphthyl, indenyl, heterobicyclics and heteromonocyclic containing 5 to 6 ring members, all optionally substituted with at least one member of the group consisting of alkyl and alkoxy of 1 to 5 carbon atoms, halogen, --OH, --CF.sub.3, --NO.sub.2, --NH.sub.2 monoalkylamino and dialkylamino of 1 to 4 alkyl carbon atoms and phenyl optionally substituted with at least one member of the group consisting of halogen and alkyl and alkoxy of 1 to 4 carbon atoms, R.sub.3 and R.sub.4 are individually hydrogen or alkyl or 1 to 5 carbon atoms or taken together with the nitrogen form a heterocyclic of 5 to 6 ring members and optionally containing --O--, --S-- or nitrogen in the ring and their non-toxic, pharmaceutically acceptable acid addition salts having central analgesic and antiarythmic activity among other activities.

    摘要翻译： 选自下列化合物的化合物：其中X选自氢，卤素和1至5个碳原子的烷基和烷氧基，R 1和R 2的所有对映异构体和非对映异构体形式。 分别选自氢和1至5个碳原子的烷基，A和B之一为“IMAGE”，另一个为R 1为氢或1至5个碳原子的烷基，Z为 - （ CH 2）2至8个碳原子的正或支链亚烷基，n为0至5的整数，Y选自萘基，茚基，异双环烯烃和含有5至6个环成员的杂单环，全部任选被 由1至5个碳原子的烷基和烷氧基，卤素，-OH，-CF 3，-NO 2，-NH 2单烷基氨基和1至4个烷基碳原子的二烷基氨基组成的组中的至少一个和任选被至少一个成员取代的苯基 由卤素和烷基组成的组中 具有1至4个碳原子的烷氧基，R 3和R 4独立地为氢或烷基或1至5个碳原子，或与氮一起形成5至6个环成员的杂环，并任选地含有-O - ， - S-或 环中的氮和它们的无毒的药学上可接受的酸加成盐，具有其他活性的中枢镇痛和抗血液活性。