公开(公告)号：US12006276B2

公开(公告)日：2024-06-11

申请号：US17629617

申请日：2020-03-25

申请人： CHENGDU SHIBEIKANG BIOMEDICAL TECHNOLOGY CO., LTD.

发明人： Guodong Cen ,  Maoting Yang ,  Shaojun Tan

IPC分类号： C07C215/44 ,  A61K31/137 ,  C07C209/52 ,  C07C213/02 ,  C07C249/02

CPC分类号： C07C213/02 ,  C07C209/52 ,  C07C249/02

摘要： A dibromobenzyl derivative with a structure shown as formula I, a stereoisomer or a pharmaceutically acceptable salt thereof and a preparation method and an application of the dibromobenzyl derivative are provided. The dibromobenzyl derivative or the stereoisomer thereof is superior in in-vivo pharmacokinetic stability and drug efficacy, and capable of being used for preparing respiratory drugs, in particular the apophlegmatic drugs.

公开(公告)号：US20220306568A1

公开(公告)日：2022-09-29

申请号：US17838817

申请日：2022-06-13

申请人： Amicus Therapeutics, Inc.

发明人： Robert Boyd

IPC分类号： C07C215/44 ,  A61P25/28 ,  C07C233/06

摘要： The present invention provides novel compounds as well as compositions and methods using the same for preventing and/or treating degenerative disorders of the central nervous system and/or lysosomal storage disorders. In particular, the present invention provides methods for preventing and/or treating Parkinson's disease, Alzheimer's disease and/or Gaucher's disease.

公开(公告)号：US10669239B2

公开(公告)日：2020-06-02

申请号：US16514835

申请日：2019-07-17

申请人： MOCHIDA PHARMACEUTICAL CO., LTD.

发明人： Fumihiko Saitoh ,  Hiroshi Nagasue

IPC分类号： C07D213/75 ,  C07D401/04 ,  C07D405/04 ,  C07D413/06 ,  C07D417/04 ,  A61P25/04 ,  A61K31/4418 ,  A61K31/506 ,  A61K31/4439 ,  A61K31/444 ,  C07D213/84 ,  A61K31/4433 ,  C07D405/14 ,  C07D213/81 ,  C07D413/12 ,  A61K45/06 ,  A61P37/00 ,  A61P1/02 ,  A61P7/00 ,  A61P13/08 ,  A61P21/00 ,  A61P25/20 ,  A61P25/28 ,  A61P31/00 ,  A61P43/00 ,  A61P1/16 ,  A61P9/00 ,  A61P9/06 ,  A61P11/06 ,  A61P37/06 ,  A61P1/18 ,  A61P3/04 ,  A61P3/06 ,  A61P11/04 ,  A61P17/00 ,  A61P19/02 ,  A61P29/02 ,  A61P31/18 ,  A61P35/02 ,  A61P3/10 ,  A61P9/12 ,  A61P13/02 ,  A61P13/10 ,  A61P13/12 ,  A61P21/02 ,  A61P25/24 ,  A61P1/00 ,  A61P11/00 ,  A61P15/00 ,  A61P25/00 ,  A61P25/08 ,  A61P25/16 ,  A61P29/00 ,  A61P1/04 ,  A61P5/14 ,  A61P11/02 ,  A61P19/10 ,  A61P35/00 ,  A61K45/00 ,  C07C213/10 ,  C07C215/44 ,  C07C271/24

摘要： The present invention aims to provide a compound having a TrkA inhibitory action, a pharmaceutically acceptable salt thereof, or a solvate thereof, a pharmaceutical composition containing the same as an active ingredient, and a preventive and/or therapeutic agent for medicinal use, in particular for a disease in which TrkA in involved (pain, cancers, inflammation/inflammatory diseases, allergic diseases, skin diseases, neurodegenerative diseases, infectious diseases, Sjogren's syndrome, endometriosis, renal diseases, osteoporosis, and the like). Specifically, the present invention provides a compound or an optical isomer thereof, a pharmaceutically acceptable salt thereof, a solvate thereof, or the like, the compound

公开(公告)号：US10562878B2

公开(公告)日：2020-02-18

申请号：US15836261

申请日：2017-12-08

申请人： Sunovion Pharmaceuticals Inc.

发明人： Liming Shao ,  Fengjiang Wang ,  Scott Christopher Malcolm ,  Michael Charles Hewitt ,  Larry R. Bush ,  Jianguo Ma ,  Mark A. Varney ,  Una Campbell ,  Sharon Rae Engel ,  Larry Wendell Hardy ,  Patrick Koch ,  John E. Campell

IPC分类号： C07D333/20 ,  C07C211/17 ,  C07C211/40 ,  C07C215/42 ,  C07C215/44 ,  C07C217/52 ,  C07C217/74 ,  C07C323/32 ,  C07D207/06 ,  C07D207/08 ,  C07D211/14 ,  C07D265/14 ,  C07D277/28 ,  C07D295/06 ,  C07D307/52 ,  C07D317/58 ,  C07D317/72 ,  C07D319/06 ,  C07D491/056 ,  C07C211/29 ,  C07D211/16

摘要： The invention relates to novel cyclohexylamine derivatives and their use in the treatment and/or prevention of central nervous system (CNS) disorders, such as depression, anxiety, schizophrenia and sleep disorder as well as methods for their synthesis. The invention also relates to pharmaceutical compositions containing the compounds of the invention, as well as methods of inhibiting reuptake of endogenous monoamines, such as dopamine, serotonin and norepinephrine from the synaptic cleft and methods of modulating one or more monoamine transporter.

公开(公告)号：US10526287B2

公开(公告)日：2020-01-07

申请号：US15567978

申请日：2016-04-22

申请人： Constellation Pharmaceuticals, Inc.

发明人： Brian K. Albrecht ,  James Edmund Audia ,  Alexandre Côté ,  Martin Duplessis ,  Victor S. Gehling ,  Jean-Christophe Harmange ,  Rishi G. Vaswani

IPC分类号： C07D211/22 ,  C07D211/26 ,  C07D309/20 ,  C07D215/44 ,  C07D317/28 ,  C07D401/04 ,  C07D401/06 ,  C07D403/04 ,  C07D403/06 ,  C07D403/10 ,  C07D405/04 ,  C07D239/30 ,  C07C215/44 ,  C07D417/06 ,  C07D263/32 ,  C07D205/12 ,  C07D207/32 ,  C07D211/36 ,  C07D213/64 ,  C07D305/06 ,  C07C255/58 ,  C07C211/09 ,  C07C211/36 ,  C07C211/40 ,  C07C215/14 ,  C07C217/08 ,  C07C229/10 ,  C07C229/38 ,  C07C229/46 ,  C07C233/41 ,  C07C237/06 ,  C07C255/24 ,  C07C215/42 ,  C07C255/30 ,  C07D211/58 ,  C07D211/76 ,  C07D213/38 ,  C07D213/69 ,  C07D213/73 ,  C07D295/195 ,  A61P35/00

摘要： Provided are novel compounds of Formula (I): and pharmaceutically acceptable salts thereof, which are useful for treating a variety of diseases, disorders or conditions, associated with LSD1. Also provided are pharmaceutical compositions comprising the novel compounds of Formula (I), pharmaceutically acceptable salts thereof, and methods for their use in treating one or more diseases, disorders or conditions, associated with LSD1.

公开(公告)号：US20160369087A1

公开(公告)日：2016-12-22

申请号：US15191041

申请日：2016-06-23

申请人： DAICEL CORPORATION

发明人： Masanori SAKANE

IPC分类号： C08K5/17 ,  C08J5/24 ,  C07C215/44 ,  C08J5/06

CPC分类号： C08K5/17 ,  C07C215/44 ,  C07C2601/14 ,  C07D303/36 ,  C08G59/1477 ,  C08G59/184 ,  C08G59/24 ,  C08J5/06 ,  C08J5/24 ,  C08J2363/02 ,  Y10T428/2918

摘要： Provided is an epoxy-amine adduct that offers high reactivity, contributes to better adhesion between a resin and a reinforcing fiber in a fiber-reinforced composite material, and can be easily blended with another component such as a resin. The epoxy-amine adduct has two or more amino groups per molecule and is obtained by a reaction of an epoxy compound (A) having two or more alicyclic epoxy groups per molecule with an amine compound (B) having two or more amino groups per molecule. The epoxy compound (A) is preferably a compound represented by Formula (a):

公开(公告)号：US09073819B2

公开(公告)日：2015-07-07

申请号：US14128310

申请日：2012-06-29

申请人： Jahanshah Amin ,  Kirpal S. Bisht ,  Meghanath Gali

发明人： Jahanshah Amin ,  Kirpal S. Bisht ,  Meghanath Gali

IPC分类号： A61K31/357 ,  C07C215/44 ,  C07D317/72 ,  C07C211/40 ,  C07C217/52 ,  C07C325/02 ,  C07C251/20 ,  C07C251/44 ,  C07C323/30

CPC分类号： C07C215/44 ,  C07C211/40 ,  C07C217/52 ,  C07C251/20 ,  C07C251/44 ,  C07C323/30 ,  C07C325/02 ,  C07C2601/14 ,  C07D317/72

摘要： Embodiments of the present disclosure provide compositions including ketamine analogs, salts, and disalts, pharmaceutical compositions including ketamine analogs, salts, or disalts, methods of treatment of a condition or disease, methods of treatment using compositions or pharmaceutical compositions, and the like.

摘要翻译： 本公开的实施方案提供了包含氯胺酮类似物，盐和糖的组合物，包括氯胺酮类似物，盐或糖的药物组合物，治疗病症或疾病的方法，使用组合物或药物组合物的治疗方法等。

公开(公告)号：US09034868B2

公开(公告)日：2015-05-19

申请号：US14083690

申请日：2013-11-19

申请人： Commissariat A L'Energie Atomique Et Aux Ene Alt. ,  Institut Curie ,  Centre National De La Recherche Scientifique

发明人： Daniel Gillet ,  Julien Barbier ,  Ludger Johannes ,  Bahne Stechmann ,  Siau-Kun Bai

IPC分类号： C07D243/12 ,  C07D243/24 ,  C07D487/04 ,  A61K31/167 ,  A61K31/341 ,  A61K31/5513 ,  C07C211/27 ,  C07C215/10 ,  C07C215/42 ,  C07C215/44 ,  C07C217/16 ,  C07C217/58 ,  C07C229/14 ,  C07C229/22 ,  C07C229/38 ,  C07C229/48 ,  C07C233/06 ,  C07C233/65 ,  C07C237/40 ,  C07C251/24 ,  C07C271/56 ,  C07C275/28 ,  C07D209/14 ,  C07D213/38 ,  C07D215/12 ,  C07D233/10 ,  C07D233/58 ,  C07D233/61 ,  C07D235/08 ,  C07D249/06 ,  C07D307/42 ,  C07D317/58 ,  C07D317/62 ,  C07D317/66 ,  C07D333/20 ,  C07D401/04 ,  C07D453/02 ,  C07D471/08

CPC分类号： C07D453/02 ,  A61K31/167 ,  A61K31/341 ,  A61K31/5513 ,  C07C211/27 ,  C07C211/38 ,  C07C215/10 ,  C07C215/42 ,  C07C215/44 ,  C07C217/16 ,  C07C217/58 ,  C07C229/14 ,  C07C229/22 ,  C07C229/38 ,  C07C229/48 ,  C07C233/06 ,  C07C233/58 ,  C07C233/65 ,  C07C237/40 ,  C07C251/24 ,  C07C271/56 ,  C07C275/28 ,  C07C317/14 ,  C07C335/02 ,  C07C2601/08 ,  C07C2602/46 ,  C07C2603/74 ,  C07D209/14 ,  C07D213/38 ,  C07D215/12 ,  C07D233/10 ,  C07D233/58 ,  C07D233/61 ,  C07D233/64 ,  C07D235/08 ,  C07D243/12 ,  C07D243/24 ,  C07D245/06 ,  C07D249/06 ,  C07D307/42 ,  C07D307/52 ,  C07D317/46 ,  C07D317/58 ,  C07D317/62 ,  C07D317/66 ,  C07D333/20 ,  C07D401/04 ,  C07D451/02 ,  C07D471/08 ,  C07D487/04 ,  Y02A50/471 ,  Y02A50/473

摘要： The present invention relates to the use of compounds of general formula (I) and (II) for the preparation of a drug for preventing and/or treating disorders caused by Shiga toxins and related toxins.

摘要翻译： 本发明涉及通式（I）和（II）的化合物在制备用于预防和/或治疗志贺毒素和相关毒素引起的疾病的药物中的应用。

公开(公告)号：US20140066409A1

公开(公告)日：2014-03-06

申请号：US13990801

申请日：2011-12-13

申请人： UNIVERSITÄT KONSTANZ ,  RHEINISCHE FRIEDRICH-WILHELMS UNIVERSITÄT BONN

发明人： Günter Mayer ,  Christina Elsbeth Luense ,  Valentin Wittmann ,  Magnus S. Schmidt

IPC分类号： C07F9/44 ,  C07C215/44

CPC分类号： C07F9/44 ,  A61K31/13 ,  A61K31/66 ,  C07C211/25 ,  C07C215/42 ,  C07C215/44 ,  C07C233/23 ,  C07C2601/14 ,  C07F9/117 ,  C07F9/5304

摘要： The present invention relates to compounds according to general formula (I), pharmaceutical compositions comprising compounds according to general formula (I) and the use of the compounds for the treatment of a bacterial infection, particularly for use as an antibiotic.

摘要翻译： 本发明涉及根据通式（I）的化合物，包含根据通式（I）的化合物的药物组合物以及用于治疗细菌感染，特别是用作抗生素的化合物的用途。

公开(公告)号：US08329676B2

公开(公告)日：2012-12-11

申请号：US12834884

申请日：2010-07-12

申请人： Kevin R. Lynch ,  Timothy L. Macdonald

发明人： Kevin R. Lynch ,  Timothy L. Macdonald

IPC分类号： A61K31/661 ,  A61K31/133 ,  C07F9/09 ,  C07C215/44

CPC分类号： C07D207/22 ,  C07C215/44 ,  C07D207/14 ,  C07D231/04 ,  C07D275/03 ,  C07D307/22 ,  C07F9/094 ,  C07F9/3882 ,  C07F9/547

摘要： The present invention provides sphingosine-1-phosphate analogs that are potent, and selective agonists at one or more S1P receptors, specifically the S1P1 receptor type, which alter lymphocyte trafficking. The compounds of the invention include compounds having a phosphate moiety as well as compounds with hydrolysis-resistant phosphate surrogates such as phosphonates, alpha-substituted phosphonates, and phosphothionates.

摘要翻译： 本发明提供了鞘氨醇-1-磷酸类似物，其是一种或多种S1P受体，特别是S1P1受体类型的有效和选择性激动剂，其改变淋巴细胞运输。 本发明的化合物包括具有磷酸酯部分的化合物以及具有水解抗性的磷酸酯替代物如膦酸盐，α-取代的膦酸盐和磷酸三乙酯的化合物。