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![8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions](/abs-image/US/2012/08/16/US20120208831A1/abs.jpg.150x150.jpg)
11.发明申请公开(公告)号：US20120208831A1
公开(公告)日：2012-08-16
申请号：US13448495
申请日：2012-04-17
申请人： Frank HIMMELSBACH , Elke LANGKOPF , Matthias ECKHARDT , Michael MARK , Roland MAIER , Ralf R. H. LOTZ , Mohammad TADAYYON
发明人： Frank HIMMELSBACH , Elke LANGKOPF , Matthias ECKHARDT , Michael MARK , Roland MAIER , Ralf R. H. LOTZ , Mohammad TADAYYON
CPC分类号： C07D473/04 , C07D473/06 , C07D473/08 , C07D519/00
摘要： The present invention relates to substituted xanthines of general formula wherein R1 to R3 are as defined herein, the tautomers, the stereoisomers, the mixtures, the prodrugs thereof and the salts thereof which have valuable pharmacological properties, particularly an inhibiting effect on the activity of the enzyme dipeptidylpeptidase-IV (DPP-IV).
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12.发明申请公开(公告)号：US20120040982A1
公开(公告)日：2012-02-16
申请号：US13280396
申请日：2011-10-25
申请人： Frank HIMMELSBACH , Michael MARK , Matthias ECKHARDT , Elke LANGKOPF , Roland MAIER , Ralf LOTZ
发明人： Frank HIMMELSBACH , Michael MARK , Matthias ECKHARDT , Elke LANGKOPF , Roland MAIER , Ralf LOTZ
IPC分类号： A61K31/5377 , A61P3/10 , C07D413/14 , A61P3/04 , A61K31/522 , C07D473/00
CPC分类号： C07D473/08 , C07D473/04 , C07D473/06 , C07D473/10 , C07D473/12
摘要： The present invention relates to substituted xanthines of general formula wherein R1 to R4 are as defined herein, the tautomers and the stereoisomers thereof, mixtures thereof, the prodrugs and the salts thereof which have valuable pharmacological properties, particularly an inhibiting effect on the activity of the enzyme dipeptidylpeptidase-IV (DPP-IV).
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13.发明申请Xanthine Derivatives, the Preparation Thereof and Their Use as Pharmaceutical Compositions 审中-公开黄嘌呤衍生物，其制备及其作为药物组合物的用途公开(公告)号：US20120035158A1
公开(公告)日：2012-02-09
申请号：US13280394
申请日：2011-10-25
申请人： Frank HIMMELSBACH , Michael MARK , Matthias ECKHARDT , Elke LANGKOPF , Roland MAIER , Ralf R.H. LOTZ
发明人： Frank HIMMELSBACH , Michael MARK , Matthias ECKHARDT , Elke LANGKOPF , Roland MAIER , Ralf R.H. LOTZ
IPC分类号： A61K31/522 , A61K31/551 , A61K31/55 , A61K31/538 , C07D519/00 , A61P19/02 , A61P3/00 , A61P3/06 , A61P9/10 , A61P3/04 , A61P37/06 , A61P19/10 , C07D473/04 , A61P3/10
CPC分类号： C07D473/08 , C07D473/04 , C07D473/06 , C07D473/10 , C07D473/12
摘要： The present invention relates to substituted xanthines of general formula wherein R1 to R4 are defined as in claim 1, the tautomers and the stereoisomers thereof, mixtures thereof, the prodrugs and the salts thereof which have valuable pharmacological properties, particularly an inhibiting effect on the activity of the enzyme dipeptidylpeptidase-IV (DPP-IV).
摘要翻译： 本发明涉及通式的取代黄嘌呤：其中R 1至R 4如权利要求1所定义，其互变异构体及其立体异构体，其混合物，其前体药物及其盐具有有价值的药理学性质，特别是对活性的抑制作用 的二肽基肽酶-IV（DPP-IV）。
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14.发明申请Xanthine derivatives, the preparation thereof and their use as pharmaceutical compositions 审中-公开黄嘌呤衍生物，其制备及其作为药物组合物的用途公开(公告)号：US20110144095A1
公开(公告)日：2011-06-16
申请号：US13032685
申请日：2011-02-23
申请人： Frank HIMMELSBACH , Michael MARK , Matthias ECKHARDT , Elke LANGKOPF , Roland MAIER , Ralf LOTZ
发明人： Frank HIMMELSBACH , Michael MARK , Matthias ECKHARDT , Elke LANGKOPF , Roland MAIER , Ralf LOTZ
IPC分类号： A61K31/55 , C07D473/08 , A61K31/522 , C07D473/04 , C07D473/06 , A61K31/551 , A61P3/04 , A61P3/10
CPC分类号： C07D473/08 , C07D473/04 , C07D473/06 , C07D473/10 , C07D473/12
摘要： The present invention relates to substituted xanthines of general formula wherein R1 to R4 are as defined herein, the tautomers and the stereoisomers thereof, mixtures thereof, the prodrugs and the salts thereof which have valuable pharmacological properties, particularly an inhibiting effect on the activity of the enzyme dipeptidylpeptidase-IV (DPP-IV).
摘要翻译： 本发明涉及通式为其中R1至R4如本文所定义的取代黄嘌呤，其互变异构体及其立体异构体，其混合物，其前体药物及其盐具有有价值的药理学性质，特别是对 酶二肽肽酶-IV（DPP-IV）。
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15.发明申请IMIDAZOPYRIDAZINONE AND IMIDAZOPYRIDONE DERIVATIVES, THE PREPARATION THEREOF AND THEIR USE AS PHARMACEUTICAL COMPOSITIONS 有权咪达唑嗪酮和咪唑吡啶衍生物，其制备方法及其作为药物组合物的用途公开(公告)号：US20090258856A1
公开(公告)日：2009-10-15
申请号：US12489716
申请日：2009-06-23
申请人： Matthias ECKHARDT , Norbert HAUEL , Elke LANGKOPF , Frank HIMMELSBACH , Iris KAUFFMANN-HEFNER , Mohammad TADAYYON , Michael MARK
发明人： Matthias ECKHARDT , Norbert HAUEL , Elke LANGKOPF , Frank HIMMELSBACH , Iris KAUFFMANN-HEFNER , Mohammad TADAYYON , Michael MARK
IPC分类号： A61K31/554 , C07D401/14 , A61K31/437 , A61P3/10 , A61P19/02 , A61P3/04 , A61P19/10 , A61P37/06 , A61K31/5025 , A61K31/517 , C07D413/14 , A61K31/536 , C07D417/14 , A61K31/5415 , A61K31/55 , A61K31/551 , A61K31/5513 , A61K31/553
CPC分类号： C07D471/04 , C07D487/04
摘要： The present invention relates to substituted imidazo-pyridinones and imidazo-pyridazinones of general formula wherein Y and R1 to R4 are defined as in claim 1, the tautomers, enantiomers, diastereomers, the mixtures thereof and the salts thereof, which have valuable pharmacological properties, particularly an inhibiting effect on the activity of the enzyme dipeptidylpeptidase-IV (DPP-IV).
摘要翻译： 本发明涉及通式的取代的咪唑并 - 吡啶酮和咪唑并哒嗪酮，其中Y和R 1至R 4如权利要求1所定义，互变异构体，对映异构体，非对映异构体，其混合物及其盐具有有价值的药理学性质， 特别是对二肽基肽酶-IV（DPP-IV）的活性的抑制作用。
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16.发明申请XANTHINE DERIVATES, THEIR PREPARATION AND THEIR USE IN PHARMACEUTICAL COMPOSITIONS 有权XANTHINE DORIVATES，他们的制剂及其在药物组合物中的应用公开(公告)号：US20090131432A1
公开(公告)日：2009-05-21
申请号：US12355011
申请日：2009-01-16
申请人： Frank HIMMELSBACH , Elke LANGKOPF , Matthias ECKHARDT , Michael MARK , Roland MAIER , Ralf R. H. LOTZ
发明人： Frank HIMMELSBACH , Elke LANGKOPF , Matthias ECKHARDT , Michael MARK , Roland MAIER , Ralf R. H. LOTZ
IPC分类号： A61K31/522 , C07D473/04 , A61P3/10 , A61P19/06 , A61P37/00 , A61P3/04 , A61K31/5377
CPC分类号： C07D473/06 , C07D473/04
摘要： Compounds of formula (I) wherein R1 to R4 are defined as in the claims, or the prodrugs or salts thereof, particularly the physiologically acceptable salts thereof, pharmaceutical compositions containing these compounds, and methods of treating type I and type II diabetes mellitus, arthritis, obesity, allograft transplantation, or calcitonin-induced osteoporosis using these compounds.
摘要翻译： 式（I）的化合物，其中R 1至R 4如权利要求中所定义，或其前药或盐，特别是其生理上可接受的盐，含有这些化合物的药物组合物，以及治疗I型和II型糖尿病，关节炎 ，肥胖，同种异体移植，或使用这些化合物的降钙素诱导的骨质疏松症。
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![8-[3-AMINO-PIPERIDIN-1-YL]-XANTHINES, THE PREPARATION THEREOF AND THEIR USE AS PHARMACEUTICAL COMPOSITIONS](/abs-image/US/2014/05/08/US20140128604A1/abs.jpg.150x150.jpg)
17.发明申请8-[3-AMINO-PIPERIDIN-1-YL]-XANTHINES, THE PREPARATION THEREOF AND THEIR USE AS PHARMACEUTICAL COMPOSITIONS 有权8- [3-氨基 - 哌啶-1-基] - 辛糖，其制备方法及其作为药物组合物的用途公开(公告)号：US20140128604A1
公开(公告)日：2014-05-08
申请号：US14154885
申请日：2014-01-14
申请人： Frank HIMMELSBACH , Elke LANGKOPF , Matthias ECKHARDT , Michael MARK , Roland MAIER , Ralf LOTZ , Mohammad TADAYYON
发明人： Frank HIMMELSBACH , Elke LANGKOPF , Matthias ECKHARDT , Michael MARK , Roland MAIER , Ralf LOTZ , Mohammad TADAYYON
IPC分类号： C07D473/04
CPC分类号： C07D473/04 , C07D473/06 , C07D473/08 , C07D519/00
摘要： The present invention relates to substituted xanthines of general formula wherein R1 to R3 are as defined herein, the tautomers, the stereoisomers, the mixtures, the prodrugs thereof and the salts thereof which have valuable pharmacological properties, particularly an inhibiting effect on the activity of the enzyme dipeptidylpeptidase-IV (DPP-IV).
摘要翻译： 本发明涉及通式为其中R1至R3如本文所定义的取代黄嘌呤，其互变异构体，立体异构体，混合物，其前药及其盐具有有价值的药理学性质，特别是对 酶二肽肽酶-IV（DPP-IV）。
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公开(公告)号：US20130225601A1
公开(公告)日：2013-08-29
申请号：US13773699
申请日：2013-02-22
IPC分类号： C07D491/044
CPC分类号： C07D491/044 , C07D491/04
摘要： The present invention relates to compounds of general formula I, wherein the groups R1, R2, and A are as defined in the application, which have valuable pharmacological properties, and in particular bind to the GPR119 receptor and modulate its activity.
摘要翻译： 本发明涉及通式I的化合物，其中R1，R2和A基团如申请中所定义，其具有有价值的药理学性质，特别是与GPR119受体结合并调节其活性。
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19.发明申请XANTHINE DERIVATIVES, THE PREPARATION THEREOF AND THEIR USE AS PHARMACEUTICAL COMPOSITIONS 审中-公开XANTHINE衍生物，其制备方法及其作为药物组合物的用途公开(公告)号：US20130165428A1
公开(公告)日：2013-06-27
申请号：US13772786
申请日：2013-02-21
申请人： Frank HIMMELSBACH , Michael MARK , Matthias ECKHARDT , Elke LANGKOPF , Roland MAIER , Ralf R.H. LOTZ
发明人： Frank HIMMELSBACH , Michael MARK , Matthias ECKHARDT , Elke LANGKOPF , Roland MAIER , Ralf R.H. LOTZ
IPC分类号： C07D473/06 , C07D473/08
CPC分类号： C07D473/08 , C07D473/04 , C07D473/06 , C07D473/10 , C07D473/12
摘要： The present invention relates to substituted xanthines of general formula wherein R1 to R4 are defined as in claim 1, the tautomers and the stereoisomers thereof, mixtures thereof, the prodrugs and the salts thereof which have valuable pharmacological properties, particularly an inhibiting effect on the activity of the enzyme dipeptidylpeptidase-IV (DPP-IV).
摘要翻译： 本发明涉及通式的取代黄嘌呤：其中R 1至R 4如权利要求1所定义，其互变异构体及其立体异构体，其混合物，其前体药物及其盐具有有价值的药理学性质，特别是对活性的抑制作用 的二肽基肽酶-IV（DPP-IV）。
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公开(公告)号：US20130018030A1
公开(公告)日：2013-01-17
申请号：US13354356
申请日：2012-01-20
申请人： Frank HIMMELSBACH , Elke LANGKOPF , Bernd NOSSE
发明人： Frank HIMMELSBACH , Elke LANGKOPF , Bernd NOSSE
IPC分类号： A61K31/506 , C07D413/14 , A61P3/10 , C07D491/048 , A61K31/497 , A61K31/5377 , C07D405/14 , A61K31/454
CPC分类号： C07D407/14 , C07D413/14 , C07D491/048
摘要： The present invention relates to compounds of general formula I, wherein the groups R1, LP, LQ, X1, X2, X3, A, n and m are as defined in the application. The compounds of formula I have valuable pharmacological properties, and in particular bind to the GPR119 receptor and modulate its activity.
摘要翻译： 本发明涉及通式I的化合物，其中基团R1，LP，LQ，X1，X2，X3，A，n和m如申请中所定义。 式I化合物具有有价值的药理学性质，特别是与GPR119受体结合并调节其活性。
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