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1.发明申请Xanthine Derivatives, the Preparation Thereof and Their Use as Pharmaceutical Compositions 审中-公开黄嘌呤衍生物，其制备及其作为药物组合物的用途公开(公告)号：US20120035158A1
公开(公告)日：2012-02-09
申请号：US13280394
申请日：2011-10-25
申请人： Frank HIMMELSBACH , Michael MARK , Matthias ECKHARDT , Elke LANGKOPF , Roland MAIER , Ralf R.H. LOTZ
发明人： Frank HIMMELSBACH , Michael MARK , Matthias ECKHARDT , Elke LANGKOPF , Roland MAIER , Ralf R.H. LOTZ
IPC分类号： A61K31/522 , A61K31/551 , A61K31/55 , A61K31/538 , C07D519/00 , A61P19/02 , A61P3/00 , A61P3/06 , A61P9/10 , A61P3/04 , A61P37/06 , A61P19/10 , C07D473/04 , A61P3/10
CPC分类号： C07D473/08 , C07D473/04 , C07D473/06 , C07D473/10 , C07D473/12
摘要： The present invention relates to substituted xanthines of general formula wherein R1 to R4 are defined as in claim 1, the tautomers and the stereoisomers thereof, mixtures thereof, the prodrugs and the salts thereof which have valuable pharmacological properties, particularly an inhibiting effect on the activity of the enzyme dipeptidylpeptidase-IV (DPP-IV).
摘要翻译： 本发明涉及通式的取代黄嘌呤：其中R 1至R 4如权利要求1所定义，其互变异构体及其立体异构体，其混合物，其前体药物及其盐具有有价值的药理学性质，特别是对活性的抑制作用 的二肽基肽酶-IV（DPP-IV）。
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2.发明申请XANTHINE DERIVATIVES, THE PREPARATION THEREOF AND THEIR USE AS PHARMACEUTICAL COMPOSITIONS 审中-公开XANTHINE衍生物，其制备方法及其作为药物组合物的用途公开(公告)号：US20130165428A1
公开(公告)日：2013-06-27
申请号：US13772786
申请日：2013-02-21
申请人： Frank HIMMELSBACH , Michael MARK , Matthias ECKHARDT , Elke LANGKOPF , Roland MAIER , Ralf R.H. LOTZ
发明人： Frank HIMMELSBACH , Michael MARK , Matthias ECKHARDT , Elke LANGKOPF , Roland MAIER , Ralf R.H. LOTZ
IPC分类号： C07D473/06 , C07D473/08
CPC分类号： C07D473/08 , C07D473/04 , C07D473/06 , C07D473/10 , C07D473/12
摘要： The present invention relates to substituted xanthines of general formula wherein R1 to R4 are defined as in claim 1, the tautomers and the stereoisomers thereof, mixtures thereof, the prodrugs and the salts thereof which have valuable pharmacological properties, particularly an inhibiting effect on the activity of the enzyme dipeptidylpeptidase-IV (DPP-IV).
摘要翻译： 本发明涉及通式的取代黄嘌呤：其中R 1至R 4如权利要求1所定义，其互变异构体及其立体异构体，其混合物，其前体药物及其盐具有有价值的药理学性质，特别是对活性的抑制作用 的二肽基肽酶-IV（DPP-IV）。
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3.发明申请公开(公告)号：US20120252782A1
公开(公告)日：2012-10-04
申请号：US13523938
申请日：2012-06-15
申请人： Frank HIMMELSBACH , Michael MARK , Matthias ECKHARDT , Elke LANGKOPF , Roland MAIER , Ralf R.H. LOTZ
发明人： Frank HIMMELSBACH , Michael MARK , Matthias ECKHARDT , Elke LANGKOPF , Roland MAIER , Ralf R.H. LOTZ
IPC分类号： A61K31/522 , A61K31/55 , C07D473/06 , A61K31/5377 , A61P3/10 , A61P3/00 , A61P3/08 , A61P3/06 , A61P19/02 , A61P9/10 , A61P3/04 , A61P37/06 , A61P19/10 , A61K31/538 , C07D473/08
CPC分类号： C07D473/08 , C07D473/04 , C07D473/06 , C07D473/10 , C07D473/12
摘要： The present invention relates to substituted xanthines of general formula wherein R1 to R4 are defined as in claim 1, the tautomers and the stereoisomers thereof, mixtures thereof, the prodrugs and the salts thereof which have valuable pharmacological properties, particularly an inhibiting effect on the activity of the enzyme dipeptidylpeptidase-IV (DPP-IV).
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4.发明申请Xanthine Derivatives, the Preparation Thereof and Their Use as Pharmaceutical Compositions 审中-公开黄嘌呤衍生物，其制备及其作为药物组合物的用途公开(公告)号：US20100173916A1
公开(公告)日：2010-07-08
申请号：US12724653
申请日：2010-03-16
申请人： Frank HIMMELSBACH , Michael MARK , Matthias ECKHARDT , Elke LANGKOPF , Roland MAIER , Ralf R.H. LOTZ
发明人： Frank HIMMELSBACH , Michael MARK , Matthias ECKHARDT , Elke LANGKOPF , Roland MAIER , Ralf R.H. LOTZ
IPC分类号： A61K31/52 , C07D473/00 , A61P3/10 , A61P19/02 , A61P9/10 , A61P19/10 , A61P3/04 , A61K31/522
CPC分类号： C07D473/08 , C07D473/04 , C07D473/06 , C07D473/10 , C07D473/12
摘要： The present invention relates to substituted xanthines of general formula wherein R1 to R4 are defined as in claim 1, the tautomers and the stereoisomers thereof, mixtures thereof, the prodrugs and the salts thereof which have valuable pharmacological properties, particularly an inhibiting effect on the activity of the enzyme dipeptidylpeptidase-IV (DPP-IV).
摘要翻译： 本发明涉及通式的取代黄嘌呤：其中R 1至R 4如权利要求1所定义，其互变异构体及其立体异构体，其混合物，其前体药物及其盐具有有价值的药理学性质，特别是对活性的抑制作用 的二肽基肽酶-IV（DPP-IV）。
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5.发明申请Xanthine derivatives, the preparation thereof and their use as pharmaceutical compositions 审中-公开黄嘌呤衍生物，其制备及其作为药物组合物的用途公开(公告)号：US20100204250A1
公开(公告)日：2010-08-12
申请号：US12767855
申请日：2010-04-27
申请人： Frank HIMMELSBACH , Michael MARK , Matthias ECKHARDT , Elke LANGKOPF , Roland MAIER , Ralf LOTZ
发明人： Frank HIMMELSBACH , Michael MARK , Matthias ECKHARDT , Elke LANGKOPF , Roland MAIER , Ralf LOTZ
IPC分类号： A61K31/522 , C07D473/28 , A61P3/04 , A61P3/08
CPC分类号： C07D473/08 , C07D473/04 , C07D473/06 , C07D473/10 , C07D473/12
摘要： The present invention relates to substituted xanthines of general formula wherein R1 to R4 are as defined herein, the tautomers and the stereoisomers thereof, mixtures thereof, the prodrugs and the salts thereof which have valuable pharmacological properties, particularly an inhibiting effect on the activity of the enzyme dipeptidylpeptidase-IV (DPP-IV).
摘要翻译： 本发明涉及通式为其中R1至R4如本文所定义的取代黄嘌呤，其互变异构体及其立体异构体，其混合物，其前体药物及其盐具有有价值的药理学性质，特别是对 酶二肽肽酶-IV（DPP-IV）。
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6.发明申请XANTHINE DERIVATIVES, THE PREPARATION THEREOF AND THEIR USE AS PHARMACEUTICAL COMPOSITIONS 审中-公开XANTHINE衍生物，其制备方法及其作为药物组合物的用途公开(公告)号：US20100144703A1
公开(公告)日：2010-06-10
申请号：US12706739
申请日：2010-02-17
申请人： Frank HIMMELSBACH , Elke LANGKOPF , Matthias ECKHARDT , Roland MAIER , Michael MARK , Mohammad TADAYYON , Ralf R. H. LOTZ
发明人： Frank HIMMELSBACH , Elke LANGKOPF , Matthias ECKHARDT , Roland MAIER , Michael MARK , Mohammad TADAYYON , Ralf R. H. LOTZ
IPC分类号： A61K31/553 , C07D473/04 , A61K31/522 , A61K31/5513 , A61K31/554
CPC分类号： C07D473/06
摘要： Disclosed are substituted xanthines of general formula wherein R1 to R4 are defined hereinbelow, the tautomers, the stereoisomers, the mixtures thereof, the prodrugs thereof and the salts thereof, which have valuable pharmacological properties, particularly an inhibitory effect on the activity of the enzyme dipeptidylpeptidase-IV (DPP-IV).
摘要翻译： 公开了以下通式的取代黄嘌呤：其中R1至R4定义如下，其互变异构体，立体异构体，其混合物，其前体药物及其盐具有有价值的药理学性质，特别是对酶二肽基肽酶的活性的抑制作用 -IV（DPP-IV）。
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7.发明申请XANTHINE DERIVATIVES, THE PREPARATION THEREOF AND THEIR USE AS PHARMACEUTICAL COMPOSITIONS 有权XANTHINE衍生物，其制备方法及其作为药物组合物的用途公开(公告)号：US20090093457A1
公开(公告)日：2009-04-09
申请号：US12331720
申请日：2008-12-10
申请人： Frank HIMMELSBACH , Elke LANGKOPF , Matthias ECKHARDT , Roland MAIER , Michael MARK , Mohammad TADAYYON , Ralf R. H. LOTZ
发明人： Frank HIMMELSBACH , Elke LANGKOPF , Matthias ECKHARDT , Roland MAIER , Michael MARK , Mohammad TADAYYON , Ralf R. H. LOTZ
IPC分类号： A61K31/522 , C07D473/04 , C07D265/14 , C07D279/16 , A61K31/54 , A61K31/554 , A61P3/00 , A61K31/5513 , A61K31/536 , C07D243/12 , C07D285/36
CPC分类号： C07D473/06
摘要： Disclosed are substituted xanthines of general formula wherein R1 to R4 are defined hereinbelow, the tautomers, the stereoisomers, the mixtures thereof, the prodrugs thereof and the salts thereof, which have valuable pharmacological properties, particularly an inhibitory effect on the activity of the enzyme dipeptidylpeptidase-IV (DPP-IV).
摘要翻译： 公开了以下通式的取代黄嘌呤：其中R1至R4定义如下，其互变异构体，立体异构体，其混合物，其前体药物及其盐具有有价值的药理学性质，特别是对酶二肽基肽酶的活性的抑制作用 -IV（DPP-IV）。
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![8-[3-AMINO-PIPERIDIN-1-YL]-XANTHINES, THE PREPARATION THEREOF AND THEIR USE AS PHARMACEUTICAL COMPOSITIONS](/abs-image/US/2014/05/08/US20140128604A1/abs.jpg.150x150.jpg)
8.发明申请8-[3-AMINO-PIPERIDIN-1-YL]-XANTHINES, THE PREPARATION THEREOF AND THEIR USE AS PHARMACEUTICAL COMPOSITIONS 有权8- [3-氨基 - 哌啶-1-基] - 辛糖，其制备方法及其作为药物组合物的用途公开(公告)号：US20140128604A1
公开(公告)日：2014-05-08
申请号：US14154885
申请日：2014-01-14
申请人： Frank HIMMELSBACH , Elke LANGKOPF , Matthias ECKHARDT , Michael MARK , Roland MAIER , Ralf LOTZ , Mohammad TADAYYON
发明人： Frank HIMMELSBACH , Elke LANGKOPF , Matthias ECKHARDT , Michael MARK , Roland MAIER , Ralf LOTZ , Mohammad TADAYYON
IPC分类号： C07D473/04
CPC分类号： C07D473/04 , C07D473/06 , C07D473/08 , C07D519/00
摘要： The present invention relates to substituted xanthines of general formula wherein R1 to R3 are as defined herein, the tautomers, the stereoisomers, the mixtures, the prodrugs thereof and the salts thereof which have valuable pharmacological properties, particularly an inhibiting effect on the activity of the enzyme dipeptidylpeptidase-IV (DPP-IV).
摘要翻译： 本发明涉及通式为其中R1至R3如本文所定义的取代黄嘌呤，其互变异构体，立体异构体，混合物，其前药及其盐具有有价值的药理学性质，特别是对 酶二肽肽酶-IV（DPP-IV）。
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9.发明申请Xanthine Derivatives, the Preparation Thereof and Their Use as Pharmaceutical Compositions 审中-公开黄嘌呤衍生物，其制备及其作为药物组合物的用途公开(公告)号：US20110144083A1
公开(公告)日：2011-06-16
申请号：US13032686
申请日：2011-02-23
申请人： Frank HIMMELSBACH , Michael MARK , Matthias ECKHARDT , Elke LANGKOPF , Roland MAIER , Ralf R. H. LOTZ
发明人： Frank HIMMELSBACH , Michael MARK , Matthias ECKHARDT , Elke LANGKOPF , Roland MAIER , Ralf R. H. LOTZ
IPC分类号： A61K31/551 , C07D473/08 , A61K31/522 , A61P3/10 , A61P3/04 , A61P5/50 , A61P3/06 , A61P19/02 , A61P19/10 , A61P37/06 , A61K31/5355
CPC分类号： C07D473/08 , C07D473/04 , C07D473/06 , C07D473/10 , C07D473/12
摘要： The present invention relates to substituted xanthines of general formula wherein R1 to R4 are defined as in claim 1, the tautomers and the stereoisomers thereof, mixtures thereof, the prodrugs and the salts thereof which have valuable pharmacological properties, particularly an inhibiting effect on the activity of the enzyme dipeptidylpeptidase-IV (DPP-IV).
摘要翻译： 本发明涉及通式的取代黄嘌呤：其中R 1至R 4如权利要求1所定义，其互变异构体及其立体异构体，其混合物，其前体药物及其盐具有有价值的药理学性质，特别是对活性的抑制作用 的二肽基肽酶-IV（DPP-IV）。
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10.发明申请Xanthine derivatives, the preparation thereof and their use as pharmaceutical compositions 审中-公开黄嘌呤衍生物，其制备及其作为药物组合物的用途公开(公告)号：US20120252783A1
公开(公告)日：2012-10-04
申请号：US13523939
申请日：2012-06-15
申请人： Frank HIMMELSBACH , Michael MARK , Matthias ECKHARDT , Elke LANGKOPF , Roland MAIER , Ralf LOTZ
发明人： Frank HIMMELSBACH , Michael MARK , Matthias ECKHARDT , Elke LANGKOPF , Roland MAIER , Ralf LOTZ
IPC分类号： A61K31/522 , A61K31/55 , A61P3/10 , A61K31/5377 , A61P3/04 , C07D473/08 , C07D473/06
CPC分类号： C07D473/08 , C07D473/04 , C07D473/06 , C07D473/10 , C07D473/12
摘要： The present invention relates to substituted xanthines of general formula wherein R1 to R4 are as defined herein, the tautomers and the stereoisomers thereof, mixtures thereof, the prodrugs and the salts thereof which have valuable pharmacological properties, particularly an inhibiting effect on the activity of the enzyme dipeptidylpeptidase-IV (DPP-IV).
摘要翻译： 本发明涉及通式为其中R1至R4如本文所定义的取代黄嘌呤，其互变异构体及其立体异构体，其混合物，其前体药物及其盐具有有价值的药理学性质，特别是对 酶二肽肽酶-IV（DPP-IV）。
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