公开(公告)号：US20170219541A1

公开(公告)日：2017-08-03

申请号：US15329199

申请日：2015-07-06

Applicant: GE HEALTHCARE BIOPROCESS R&D AB

Inventor： Klaus Gebauer ,  Mats Lundkvist ,  Bjorn Olovsson

IPC: G01N30/60 ,  G01N30/88 ,  G01N30/46

CPC classification number: G01N30/6039 ,  B01D15/1864 ,  G01N30/465 ,  G01N30/468 ,  G01N30/6034 ,  G01N30/88 ,  G01N2030/027 ,  G01N2030/8881

Abstract: The invention discloses a flow control block for a stack of chromatography column modules, as well as a stack of chromatography modules comprising at least one flow control block. The flow control block is in a first position or configuration capable of connecting two chromatography column modules, or a chromatography column module and an endpiece, in parallel and in a second position or configuration it is capable of connecting two chromatography column modules, or a chromatography column module and an endpiece, in series.

公开(公告)号：US10933350B2

公开(公告)日：2021-03-02

申请号：US16154639

申请日：2018-10-08

Applicant: GE Healthcare BioProcess R&D AB

Inventor： Klaus Gebauer

IPC: B01D15/14 ,  B01D15/18 ,  B01D15/22 ,  G01N30/60 ,  G01N30/88 ,  G01N30/46

Abstract: A parallel assembly of chromatography column modules, the assembly having one common assembly inlet and one common assembly outlet, each column module comprising a bed space filled with chromatography medium and each column module comprises integrated fluid conduits which when the column module is connected with other column modules are adapted to connect the bed space of the column module with the assembly inlet and the assembly outlet, wherein the total length and/or volume of the fluid conduit from the assembly inlet to one bed space together with the length and/or volume of the fluid conduit from the same bed space to the assembly outlet is substantially the same for all bed spaces and modules installed in the parallel assembly.

公开(公告)号：US20180361272A1

公开(公告)日：2018-12-20

申请号：US15781305

申请日：2016-12-07

Applicant: GE HEALTHCARE BIOPROCESS R&D AB

Inventor： Dan Hermansson ,  Klaus Gebauer ,  Mats Lundkvist

IPC: B01D15/18 ,  G01N30/88 ,  G01N30/46 ,  G01N30/60 ,  B01D15/22

Abstract: The invention discloses a chromatography column module stackable with like chromatography modules, comprising a column chamber (2) fluidically connected to a column inlet 3) and a column outlet (4), wherein the column inlet and outlet each comprise a valve (5), arranged to move from a closed position to an open position upon connection of the column inlet or outlet with a) a column outlet or inlet of a like chromatography module or b) with an outlet or inlet of a fluidics plate. The invention further discloses a stack of chromatography column modules and the use of the stack for separation of biomolecules.

公开(公告)号：US10092856B2

公开(公告)日：2018-10-09

申请号：US15793923

申请日：2017-10-25

Applicant: GE Healthcare BioProcess R&D AB

Inventor： Klaus Gebauer

IPC: B01D15/14 ,  B01D15/18 ,  B01D15/22 ,  G01N30/60 ,  G01N30/46 ,  G01N30/88

Abstract: A parallel assembly (2; 11; 51) of chromatography column modules (3a,b,c; 13a,b,c; 53a,b,c, 90a, b), the assembly having one common assembly inlet (15; 55) and one common assembly outlet (17; 57), each column module comprising a bed space (29) filled with chromatography medium and each column module comprises integrated fluid conduits which when the column module is connected with other column modules are adapted to connect the bed space (29) of the column module with the assembly inlet (15; 55) and the assembly outlet (17; 57), wherein the total length and/or volume of the fluid conduit from the assembly inlet to one bed space together with the length and/or volume of the fluid conduit from the same bed space to the assembly outlet is substantially the same for all bed spaces and modules installed in the parallel assembly.