公开(公告)号：US09125955B2

公开(公告)日：2015-09-08

申请号：US14072846

申请日：2013-11-06

Applicant: GENERAL ELECTRIC COMPANY

Inventor： Bruce Fletcher Johnson ,  Randall Lee Carter ,  Michael James Rishel ,  Mark Christopher Patrick Darey ,  Tao Wu ,  Yang Yang ,  John Fitzmaurice Valliant ,  Karin Ann Stephenson

IPC: A61K51/04 ,  A61K51/06 ,  A61K51/08 ,  A61K38/00 ,  A61K51/10

CPC classification number: A61K51/1093 ,  A61K51/04 ,  A61K51/0474 ,  A61K51/0491 ,  A61K51/08 ,  A61K51/088 ,  C07C311/18

Abstract: An embodiment of the invention comprises method of imaging a target site comprising administrating ligand of Formula I complexed to 99mTc wherein R1 and R2 are independently an alkyl or cycloalkyl; R3 is and alkyl; X is CO or SO2; Y is (CH2)n, C6H4, (OCH2CH2)n(NHCH2CH2)n and (OCH2CH2CH2)n, or a combination thereof; Z is linker group capable of conjugating to a vector; and n is an integer between 0 and 10.

Abstract translation: 本发明的一个实施方案包括对靶位点进行成像的方法，该方法包括施用络合到99mTc的式I配体，其中R 1和R 2独立地是烷基或环烷基; R3是和烷基; X是CO或SO2; Y是（CH 2）n，C 6 H 4，（OCH 2 CH 2）n（NHCH 2 CH 2）n和（OCH 2 CH 2 CH 2）n，或其组合; Z是能够与载体缀合的连接基团; n为0〜10的整数。