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公开(公告)号：US20140088314A1
公开(公告)日：2014-03-27
申请号：US13626918
申请日：2012-09-26
Applicant: GENERAL ELECTRIC COMPANY
Inventor： Brian James Grimmond , Michael James Rishel
IPC: C07F9/40 , C07C229/16 , C07F19/00 , C07F7/10
CPC classification number: C07F15/025 , A61K49/103 , C07C229/16 , C07C229/76 , C07F7/0812 , C07F9/3808 , C07F9/4006 , C07F9/409 , C07F9/65586 , Y02P20/55
Abstract: A chelating agent, a metal-chelate, and a contrast agent are provided, wherein the chelating agent comprises a compound of structure (I) wherein R1, R2, R3, R8, R7, R′7 R′1, R′2, R′3 and R8′ are selected from a hydrogen, a protected C1-C3 hydroxyalkyl group, a C1-C3 alkyl group; R4 and R′4 are selected from a hydrogen, a hydroxyl group, a protected hydroxy group, a protected C1-C3 hydroxyalkyl group, a C1-C3 alkyl group; n is an integer between 0 and 4; R5 and R′5 are selected from a hydrogen, a protecting group selected from the group consisting of C1-C30 aliphatic radicals, C3-C30 cycloaliphatic radicals, C2-C30 aromatic radicals; R9 and R′9 are selected form a hydrogen or a protecting group selected from the group consisting of C1-C30 aliphatic radicals, C3-C30 cycloaliphatic radicals, C2-C30 aromatic radicals, m is an integer between 0 and 10; and at least one of R7 and R′7 is acidic group or a protected acidic group.
Abstract translation: 提供螯合剂，金属螯合物和造影剂，其中螯合剂包括结构式（I）的化合物，其中R1，R2，R3，R8，R7，R'7R'1，R'2， R'3和R 8'选自氢，被保护的C 1 -C 3羟烷基，C 1 -C 3烷基; R 4和R 4选自氢，羟基，保护的羟基，被保护的C 1 -C 3羟烷基，C 1 -C 3烷基; n是0和4之间的整数; R 5和R 5选自氢，选自C 1 -C 30脂族基，C 3 -C 30脂环族基，C 2 -C 30芳族基的保护基; R 9和R 9选自由C 1 -C 30脂族基团，C 3 -C 30脂环族基团，C 2 -C 30芳族基团组成的组中的氢或保护基团，m为0至10的整数; 并且R 7和R 7中的至少一个是酸性基团或被保护的酸性基团。
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公开(公告)号：US20230181399A1
公开(公告)日：2023-06-15
申请号：US17967665
申请日：2021-04-19
Applicant: General Electric Company
Inventor： Bruno Kristiaan Bernard De Man , Paul Francis FitzGerald , Stephen Lorenco Araujo , Uwe Wiedmann , Michael James Rishel , Ross Christopher Stalter
CPC classification number: A61G10/02 , A61G10/005 , A61G2210/50
Abstract: Systems are provided for a patient isolation unit for use with a medical imaging system includes an enclosure comprised of a pathogen impermeable material compatible with one or more imaging systems. The enclosure includes a base, a first end wall coupled to a first end of the base, a second end wall coupled to a second end of the base, and a cover coupled to a first side of the base, second side of the base, the first end wall and the second end wall for substantially enclosing a patient therein. In another exemplary embodiment, a patient isolation unit for use with a medical imaging system includes a head enclosure comprised of a pathogen impermeable material and a body enclosure coupled to the head enclosure and comprised of a pathogen impermeable material.
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公开(公告)号：US09155804B2
公开(公告)日：2015-10-13
申请号：US13626942
申请日：2012-09-26
Applicant: General Electric Company
CPC classification number: A61K49/126
Abstract: A contrast agent composition and a method of diagnostic imaging are provided. The composition comprises a pharmaceutically acceptable carrier and a metal-complex comprising a ligand having structure (XXX): wherein R1, R2, R3, R7, R8, R′1, R′2, R′3, R7′ and R8′ are selected form hydrogen, a protected C1-C3 hydroxyalkyl group, or a C1-C3 alkyl group; R4, R′4 are selected from a hydrogen, a hydroxyl, a protected hydroxyl group, a protected C1-C3 hydroxyalkyl group, a C1-C3 alkyl group; n is an integer between 0 and 4; R5, R′5 are selected from a hydrogen, a protecting group comprising C1-C30 aliphatic radicals, C3-C30 cycloaliphatic radicals, C2-C30 aromatic radicals, m is an integer between 1 and 10; at least one of R7 and R′7 is acidic groups or protected acidic groups; Y comprises a protein or peptide moiety, a particle, a micelle, a liposome, an organic molecule, oligomer, polymer or a hydrophilic moiety.
Abstract translation: 提供造影剂组合物和诊断成像方法。 该组合物包含药学上可接受的载体和包含具有结构（XXX）的配体的金属络合物：其中R1，R2，R3，R7，R8，R'1，R'2，R'3，R7'和R8'是 选自氢，受保护的C1-C3羟烷基或C1-C3烷基; R 4，R'4选自氢，羟基，被保护的羟基，保护的C 1 -C 3羟烷基，C 1 -C 3烷基; n是0和4之间的整数; R5，R'5选自氢，包含C1-C30脂族基团，C3-C30脂环族基团，C2-C30芳族基团的保护基，m是1-10之间的整数; R 7和R 7中的至少一个是酸性基团或被保护的酸性基团; Y包括蛋白质或肽部分，颗粒，胶束，脂质体，有机分子，低聚物，聚合物或亲水部分。
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公开(公告)号：US20170035914A1
公开(公告)日：2017-02-09
申请号：US14818372
申请日：2015-08-05
Applicant: General Electric Company
Inventor： Erik Leeming Kvam , Michael James Rishel , Andrew Arthur Paul Burns
IPC: A61K49/00
CPC classification number: A61K49/0056 , A61K49/0043
Abstract: Disclosed are novel cell-penetrating transporters for enhancing cellular uptake of peptide fusion proteins into live cells. The cell-penetrating transporters comprise a functionalized peptide construct comprising a cell importation peptide covalently bound to a cargo, the cell importation peptide in an unreactive monomeric form, and a pharmaceutical carrier. In certain embodiments, the cargo further comprises a nuclear localization sequence (NLS) allowing the cargo to be transported across the nuclear membrane.
Abstract translation: 公开了用于增强肽融合蛋白到活细胞中的细胞摄取的新型细胞穿透转运蛋白。 细胞穿透转运蛋白包含功能化的肽构建体，其包含与货物共价结合的细胞进入肽，细胞进口肽以非反应性单体形式和药物载体。 在某些实施方案中，货物还包括允许货物跨过核膜运输的核定位序列（NLS）。
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公开(公告)号：US20150099650A1
公开(公告)日：2015-04-09
申请号：US14047233
申请日：2013-10-07
Applicant: General Electric Company
Inventor： Anup Sood , Arunkumar Natarajan , Michael James Rishel , Michael John Gerdes
IPC: C12Q1/68
CPC classification number: C12Q1/6825 , C12Q2523/319 , G01N33/53 , G01N33/533 , G01N33/542 , G01N33/6854
Abstract: Disclosed are high throughput methods of probing multiple targets in a biological sample where the recurrent time-consuming antibody incubation steps and individual signal modification and activation steps are replaced by simultaneous hybridization of biomarkers and sequential detection by combining signal removal and activation into a single step. Also disclosed are images obtained by such methods.
Abstract translation: 公开了探测生物样品中多个靶标的高通量方法，其中复发耗时的抗体孵育步骤和单独的信号修饰和激活步骤被生物标志物的同时杂交和通过将信号去除和活化组合到单个步骤中的顺序检测来代替。 还公开了通过这种方法获得的图像。
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Patent Agency Ranking
公开(公告)号：US20140086846A1
公开(公告)日：2014-03-27
申请号：US13626942
申请日：2012-09-26
Applicant: GENERAL ELECTRIC COMPANY
CPC classification number: A61K49/126
Abstract: A contrast agent composition and a method of diagnostic imaging are provided. The composition comprises a pharmaceutically acceptable carrier and a metal-complex comprising a ligand having structure (XXX): wherein R1, R2, R3, R7, R8, R′1, R′2, R′3, R7′ and R8′ are selected form hydrogen, a protected C1-C3 hydroxyalkyl group, or a C1-C3 alkyl group; R4, R′4 are selected from a hydrogen, a hydroxyl, a protected hydroxyl group, a protected C1-C3 hydroxyalkyl group, a C1-C3 alkyl group; n is an integer between 0 and 4; R5, R′5 are selected from a hydrogen, a protecting group comprising C1-C30 aliphatic radicals, C3-C30 cycloaliphatic radicals, C2-C30 aromatic radicals, m is an integer between 1 and 10; at least one of R7 and R′7 is acidic groups or protected acidic groups; Y comprises a protein or peptide moiety, a particle, a micelle, a liposome, an organic molecule, oligomer, polymer or a hydrophilic moiety.
Abstract translation: 提供造影剂组合物和诊断成像方法。 该组合物包含药学上可接受的载体和包含具有结构（XXX）的配体的金属络合物：其中R1，R2，R3，R7，R8，R'1，R'2，R'3，R7'和R8'是 选自氢，受保护的C1-C3羟烷基或C1-C3烷基; R 4，R'4选自氢，羟基，被保护的羟基，保护的C 1 -C 3羟烷基，C 1 -C 3烷基; n是0和4之间的整数; R5，R'5选自氢，包含C1-C30脂族基团，C3-C30脂环族基团，C2-C30芳族基团的保护基，m是1-10之间的整数; R 7和R 7中的至少一个是酸性基团或被保护的酸性基团; Y包括蛋白质或肽部分，颗粒，胶束，脂质体，有机分子，低聚物，聚合物或亲水部分。
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公开(公告)号：US20140065065A1
公开(公告)日：2014-03-06
申请号：US14072846
申请日：2013-11-06
Applicant: GENERAL ELECTRIC COMPANY
Inventor： Bruce Fletcher Johnson , Randall Lee Carter , Michael James Rishel , Mark Christopher Patrick Darey , Tao Wu , Yang Yang , John Fitzmaurice Valliant , Karin Ann Stephenson
CPC classification number: A61K51/1093 , A61K51/04 , A61K51/0474 , A61K51/0491 , A61K51/08 , A61K51/088 , C07C311/18
Abstract: An embodiment of the invention comprises method of imaging a target site comprising administrating ligand of Formula I complexed to 99mTc wherein R1 and R2 are independently an alkyl or cycloalkyl; R3 is and alkyl; X is CO or SO2; Y is (CH2)n, C6H4, (OCH2CH2)n (NHCH2CH2)n and (OCH2CH2CH2)n, or a combination thereof; Z is linker group capable of conjugating to a vector; and n is an integer between 0 and 10.
Abstract translation: 本发明的一个实施方案包括对靶位点进行成像的方法，该方法包括施用络合到99mTc的式I配体，其中R 1和R 2独立地是烷基或环烷基; R3是和烷基; X是CO或SO2; Y是（CH 2）n，C 6 H 4，（OCH 2 CH 2）n（NHCH 2 CH 2）n和（OCH 2 CH 2 CH 2）n，或其组合; Z是能够与载体缀合的连接基团; n为0〜10的整数。
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公开(公告)号：US11110186B2
公开(公告)日：2021-09-07
申请号：US16956995
申请日：2018-12-20
Applicant: GENERAL ELECTRIC COMPANY
Inventor： Brian Christopher Bales , Michael James Rishel
Abstract: The invention provides compounds suitable for use as contrast agents in magnetic resonance imaging (MRI). The compounds of the present invention are manganese (II) complexes having advantageous properties as compared with similar known compounds.
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9.发明公开公开(公告)号：US20240122777A1
公开(公告)日：2024-04-18
申请号：US17967722
申请日：2022-10-17
Applicant: General Electric Company
Inventor： Paul Francis FitzGerald , Uwe Wiedmann , Ross Christopher Stalter , Stephen Lorenco Araujo , Michael James Rishel , Chad Allan Smith
CPC classification number: A61G10/005 , A61B6/4423 , A61G10/02 , G01R33/28 , A61B6/032
Abstract: Systems are provided for an imaging system isolation enclosure for use with a medical imaging system includes a pathogen impermeable enclosure for use with one or more of radiation imaging systems and magnetic resonance imaging systems, the pathogen impermeable enclosure is configured to provide a barrier between the imaging system and at least one of a patient user and an imaging room, and an air filtration system including an inlet to supply a cooling air flow to an interior of the imaging system isolation enclosure and an outlet to output exhaust air from an interior of the imaging system isolation enclosure.
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公开(公告)号：US09322051B2
公开(公告)日：2016-04-26
申请号：US14047233
申请日：2013-10-07
Applicant: GENERAL ELECTRIC COMPANY
Inventor： Anup Sood , Arunkumar Natarajan , Michael James Rishel , Michael John Gerdes
IPC: C12Q1/68 , G01N33/68 , G01N33/53 , G01N33/533 , G01N33/542 , G01N33/543
CPC classification number: C12Q1/6825 , C12Q2523/319 , G01N33/53 , G01N33/533 , G01N33/542 , G01N33/6854
Abstract: Disclosed are high throughput methods of probing multiple targets in a biological sample where the recurrent time-consuming antibody incubation steps and individual signal modification and activation steps are replaced by simultaneous hybridization of biomarkers and sequential detection by combining signal removal and activation into a single step. Also disclosed are images obtained by such methods.
Abstract translation: 公开了探测生物样品中多个靶标的高通量方法，其中复发耗时的抗体孵育步骤和单独的信号修饰和激活步骤被生物标志物的同时杂交和通过将信号去除和活化组合到单个步骤中的顺序检测来代替。 还公开了通过这种方法获得的图像。
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