公开(公告)号：US10059699B2

公开(公告)日：2018-08-28

申请号：US15509894

申请日：2015-09-09

申请人： GlaxoSmithKline Intellectual Property (No.2) Limited

发明人： Stephen John Atkinson ,  David Jonathan Hirst ,  Philip G. Humphreys ,  Matthew J. Lindon ,  Alexander G. Preston ,  Jonathan Thomas Seal ,  Christopher Roland Wellaway

IPC分类号： C07D405/14 ,  C07D401/12

摘要： The present invention relates to specific novel compounds, pharmaceutical compositions containing such compounds and to their use in therapy as bromodomain inhibitors.

公开(公告)号：US11319307B2

公开(公告)日：2022-05-03

申请号：US16753543

申请日：2018-10-04

申请人： GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED

发明人： Stephen John Atkinson ,  Emmanuel Hubert Demont ,  Lee Andrew Harrison ,  Simon Christopher Cranko Lucas ,  Alexander G. Preston ,  Jonathan Thomas Seal ,  Ian David Wall ,  Robert J. Watson ,  James Michael Woolven

IPC分类号： C07D413/12 ,  C07D307/80 ,  C07D405/12 ,  C07D407/12 ,  A61K45/06

摘要： The present invention relates to compounds of formula (I) and salts thereof, pharmaceutical compositions containing such compounds and to their use in therapy.

公开(公告)号：US10934272B2

公开(公告)日：2021-03-02

申请号：US16091567

申请日：2017-04-05

申请人： GlaxoSmithKline Intellectual Property (No. 2) Limited

发明人： Stephen John Atkinson ,  Emmanuel Hubert Demont ,  Lee Andrew Harrison ,  Etienne Levernier ,  Alexander G. Preston ,  Jonathan Thomas Seal ,  Ian David Wall ,  Robert J. Watson ,  James Michael Woolven

IPC分类号： C07D401/12 ,  C07D401/14 ,  C07D405/12 ,  C07D413/12 ,  C07D471/04 ,  C07D413/14 ,  A61K45/06 ,  A61K31/4427 ,  A61K31/443 ,  A61K31/453 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/496 ,  A61K31/5377 ,  C07D213/81 ,  C07D405/14

摘要： The present invention relates to compounds of formula (I) and salts thereof, pharmaceutical compositions containing such compounds and to their use in therapy.

公开(公告)号：US10927080B2

公开(公告)日：2021-02-23

申请号：US16535139

申请日：2019-08-08

申请人： GlaxoSmithKline Intellectual Property (No.2) Limited

发明人： Stephen John Atkinson ,  Helen Elizabeth Aylott ,  Anthony William James Cooper ,  Emmanuel Hubert Demont ,  Lee Andrew Harrison ,  Thomas George Christopher Hayhow ,  Matthew J. Lindon ,  Alexander G. Preston ,  Jonathan Thomas Seal ,  Ian David Wall ,  Robert J. Watson ,  James Michael Woolven

IPC分类号： C07D213/82 ,  A61K31/44 ,  C07D401/06 ,  C07D405/06 ,  C07D413/06 ,  C07D471/04

摘要： The present invention relates to compounds of formula (I) and salts thereof, pharmaceutical compositions containing such compounds and to their use in therapy

公开(公告)号：US10583112B2

公开(公告)日：2020-03-10

申请号：US16091577

申请日：2017-04-05

申请人： GlaxoSmithKline Intellectual Property (No. 2) Limited

发明人： Stephen John Atkinson ,  Emmanuel Hubert Demont ,  Lee Andrew Harrison ,  Alexander G. Preston ,  Jonathan Thomas Seal ,  Ian David Wall ,  Robert J. Watson ,  James Michael Woolven

IPC分类号： A61K31/343 ,  A61P37/00 ,  A61P31/12 ,  A61P19/02 ,  A61P31/04 ,  A61P31/10 ,  A61P35/00

摘要： The present invention relates to compounds of formula (I) and salts thereof, pharmaceutical compositions containing such compounds and to their use in therapy.

公开(公告)号：US10428026B2

公开(公告)日：2019-10-01

申请号：US15757199

申请日：2016-08-31

申请人： GlaxoSmithKline Intellectual Property (No.2) Limited

发明人： Stephen John Atkinson ,  Helen Elizabeth Aylott ,  Anthony William James Cooper ,  Emmanuel Hubert Demont ,  Lee Andrew Harrison ,  Thomas George Christopher Hayhow ,  Matthew J. Lindon ,  Alexander G. Preston ,  Jonathan Thomas Seal ,  Ian David Wall ,  Robert J. Watson ,  James Michael Woolven

IPC分类号： C07D213/82 ,  C07D401/06 ,  C07D405/06 ,  C07D413/06 ,  C07D471/04

摘要： The present invention relates to compounds of formula (I) and salts thereof, pharmaceutical compositions containing such compounds and to their use in therapy