公开(公告)号：US20130303623A1

公开(公告)日：2013-11-14

申请号：US13891306

申请日：2013-05-10

申请人： GRÜNENTHAL GMBH

发明人： LUTZ BARNSCHEID ,  ERIC GALIA ,  ANJA GEIßLER ,  JANA PÄTZ ,  SEBASTIAN SCHWIER ,  JULIA BARONSKY-PROBST

IPC分类号： A61K47/10 ,  A61K31/137

CPC分类号： A61K47/10 ,  A61K9/2031 ,  A61K9/2054 ,  A61K31/137

摘要： A thermoformed, tamper-resistant pharmaceutical dosage form comprises: a) a pharmacologically active ingredient; b) a polyalkylene oxide having a weight average molecular weight of more than 200,000 g/mol; and c) a zinc component, wherein the content of said zinc component is at least 1 ppm, relative to the total weight of the pharmaceutical dosage form. When the pharmacologically active ingredient is effective against pain, the pharmaceutical dosage form may be used in a method of treating pain. When the pharmacologically active ingredient has abuse potential, the pharmaceutical dosage form may be used in a method of reducing the incidence of the abuse of said pharmacologically active ingredient.

摘要翻译： 热成型防篡改药物剂型包括：a）药理活性成分; b）重均分子量大于200,000g / mol的聚环氧烷; 和c）锌组分，其中所述锌组分的含量相对于药物剂型的总重量为至少1ppm。 当药理活性成分对疼痛有效时，药物剂型可用于治疗疼痛的方法。 当药理活性成分具有滥用潜力时，药物剂型可用于降低滥用所述药理活性成分的发生率的方法。