利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

11 条记录 (耗时 0.027 秒)

    TAMPER-RESISTANT DOSAGE FORM WITH IMMEDIATE RELEASE AND RESISTANCE AGAINST SOLVENT EXTRACTION
    4.
    发明申请
    TAMPER-RESISTANT DOSAGE FORM WITH IMMEDIATE RELEASE AND RESISTANCE AGAINST SOLVENT EXTRACTION 审中-公开

    公开(公告)号：US20200276188A1

    公开(公告)日：2020-09-03

    申请号：US16871150

    申请日：2020-05-11

    申请人： Grünenthal GMBH

    发明人： KLAUS WENING ,  ANJA GEIßLER ,  JANA DENKER ,  LUTZ BARNSCHEID

    IPC分类号： A61K31/485 ,  A61K9/16 ,  A61K9/20 ,  A61K9/48 ,  A61K9/50 ,  A61K31/137

    摘要： A tamper-resistant pharmaceutical dosage form comprising a multitude of particles which comprise a pharmacologically active compound, a polyalkylene oxide, and a disintegrant; wherein the pharmacologically active compound is dispersed in a matrix comprising the polyalkylene oxide and the disintegrant; wherein the content of the disintegrant is more than 5.0 wt.-%, based on the total weight of the pharmaceutical dosage form and/or based on the total weight of the particles; wherein the content of the polyalkylene oxide is at least 25 wt.-%, based on the total weight of the pharmaceutical dosage form and/or based on the total weight of the particles; and wherein the dosage form provides under in vitro conditions immediate release of the pharmacologically active compound in accordance with Ph. Eur.

    TAMPER-RESISTANT DOSAGE FORM WITH IMMEDIATE RELEASE AND RESISTANCE AGAINST SOLVENT EXTRACTION
    7.
    发明申请
    TAMPER-RESISTANT DOSAGE FORM WITH IMMEDIATE RELEASE AND RESISTANCE AGAINST SOLVENT EXTRACTION 审中-公开
    具有立即释放和抵抗溶剂萃取的抗ANT药剂型

    公开(公告)号：US20160310429A1

    公开(公告)日：2016-10-27

    申请号：US15135649

    申请日：2016-04-22

    申请人： GRÜNENTHAL GMBH

    发明人： KLAUS WENING ,  ANJA GEIßLER ,  JANA DENKER ,  LUTZ BARNSCHEID

    IPC分类号： A61K9/16 ,  A61K9/48 ,  A61K31/137 ,  A61K9/20 ,  A61K9/50 ,  A61K31/485

    CPC分类号： A61K31/485 ,  A61K9/1611 ,  A61K9/1617 ,  A61K9/1635 ,  A61K9/1641 ,  A61K9/1652 ,  A61K9/1658 ,  A61K9/1694 ,  A61K9/2077 ,  A61K9/4808 ,  A61K9/50 ,  A61K31/137

    摘要： A tamper-resistant pharmaceutical dosage form comprising a multitude of particles which comprise a pharmacologically active compound, a polyalkylene oxide, and a disintegrant; wherein the pharmacologically active compound is dispersed in a matrix comprising the polyalkylene oxide and the disintegrant; wherein the content of the disintegrant is more than 5.0 wt.-%, based on the total weight of the pharmaceutical dosage form and/or based on the total weight of the particles; wherein the content of the polyalkylene oxide is at least 25 wt.-%, based on the total weight of the pharmaceutical dosage form and/or based on the total weight of the particles; and wherein the dosage form provides under in vitro conditions immediate release of the pharmacologically active compound in accordance with Ph. Eur.

    摘要翻译： 包含许多包含药理活性化合物，聚环氧烷和崩解剂的颗粒的防篡改药物剂型; 其中药理活性化合物分散在包含聚环氧烷和崩解剂的基质中; 其中所述崩解剂的含量基于所述药物剂型的总重量和/或基于所述颗粒的总重量而大于5.0重量％。 其中所述聚环氧烷的含量为至少25重量％，基于所述药物剂型的总重量和/或基于所述颗粒的总重量; 并且其中所述剂型在体外条件下提供根据Ph.Eur。的药理活性化合物的立即释放。

    TAMPER RESISTANT DOSAGE FORM WITH BIMODAL RELEASE PROFILE
    9.
    发明申请
    TAMPER RESISTANT DOSAGE FORM WITH BIMODAL RELEASE PROFILE 有权
    具有双重释放特征的抗癫痫剂量形式

    公开(公告)号：US20140356428A1

    公开(公告)日：2014-12-04

    申请号：US14287348

    申请日：2014-05-27

    申请人： GRÜNENTHAL GMBH

    发明人： LUTZ BARNSCHEID ,  ANJA GEIßLER ,  KLAUS WENING ,  STEFANIE STRAUCH ,  JANA PÄTZ ,  SEBASTIAN SCHWIER

    IPC分类号： A61K9/20 ,  A61K31/167 ,  A61K45/06 ,  A61K31/485

    CPC分类号： A61K9/2086 ,  A61K9/2031 ,  A61K9/209 ,  A61K9/2095 ,  A61K31/167 ,  A61K31/485 ,  A61K45/06 ,  A61K2300/00

    摘要： The invention relates to a pharmaceutical dosage form comprising (i) at least one formed segment (S1), which contains a first pharmacologically active ingredient (A1) and provides prolonged release thereof, and (ii) at least one further segment (S2), which contains a second pharmacologically active ingredient (A2) and provides immediate release thereof, wherein the at least one formed segment (S1) exhibits a higher breaking strength than the at least one further segment (S2) and the at least one formed segment (S1) exhibits a breaking strength of more than 500 N.

    摘要翻译： 本发明涉及一种药物剂型，其包含（i）至少一个形成的片段（S1），其含有第一药理活性成分（A1）并提供其延长的释放，和（ii）至少一个另外的片段（S2）， 其包含第二药理活性成分（A2）并提供其即时释放，其中所述至少一个成形段（S1）表现出比所述至少一个另外的段（S2）和所述至少一个形成的区段（S1）更高的断裂强度 ）表现出超过500N的断裂强度。

    TAMPER-RESISTANT DOSAGE FORM CONTAINING ONE OR MORE PARTICLES
    10.
    发明申请
    TAMPER-RESISTANT DOSAGE FORM CONTAINING ONE OR MORE PARTICLES 审中-公开
    具有一个或多个颗粒的抗ANT药剂型

    公开(公告)号：US20140356426A1

    公开(公告)日：2014-12-04

    申请号：US14287512

    申请日：2014-05-27

    申请人： GRÜNENTHAL GMBH

    发明人： LUTZ BARNSCHEID ,  ANJA GEIßLER ,  KLAUS WENING ,  JANA PÄTZ

    IPC分类号： A61K9/48 ,  A61K45/06 ,  A61K31/485 ,  A61K9/14 ,  A61K9/28

    CPC分类号： A61K9/4891 ,  A61K9/14 ,  A61K9/146 ,  A61K9/2081 ,  A61K9/28 ,  A61K31/485 ,  A61K45/06

    摘要： The invention relates to a tamper-resistant pharmaceutical dosage form comprising one or more particles, wherein each of said one or more particles comprises a pharmacologically active ingredient and a physiologically acceptable polymer; has a breaking strength of at least 300 N; has a weight of at least 2 mg; and optionally, comprises a film-coating; wherein the total weight of the pharmaceutical dosage form is greater than the total weight of said one or more particles.

    摘要翻译： 本发明涉及包含一种或多种颗粒的防篡改药物剂型，其中所述一种或多种颗粒中的每一种包含药理活性成分和生理上可接受的聚合物; 具有至少300N的断裂强度; 具有至少2mg的重量; 并且任选地包括膜包衣; 其中所述药物剂型的总重量大于所述一种或多种颗粒的总重量。