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    System for the Treatment of Disorders Associated with Inflammation
    14.
    发明申请
    System for the Treatment of Disorders Associated with Inflammation 有权

    公开(公告)号：US20220305259A1

    公开(公告)日：2022-09-29

    申请号：US17619561

    申请日：2020-06-17

    Applicant: Galvani Bioelectronics Limited

    Inventor： Isha Gupta ,  Matteo Donega

    IPC: A61N1/36 ,  A61N1/05

    Abstract: Stimulation of neural activity in a splenic arterial nerve at a position where the splenic artery is not in direct contact with the pancreas, can modulate pro- and anti-inflammatory molecules levels, thereby reducing inflammation and providing ways of treating disorders, such as disorders associated with inflammation. The invention provides improved ways of reducing inflammation with minimized off-target effects, in particular surgical trauma.

    Nerve stimulation system
    18.
    发明授权
    Nerve stimulation system 有权

    公开(公告)号：US12036413B2

    公开(公告)日：2024-07-16

    申请号：US17415599

    申请日：2019-12-13

    Applicant: Galvani Bioelectronics Limited

    Inventor： David Karl Lee Peterson ,  Daniel John Chew ,  Matteo Donega ,  Xu Meng

    IPC: A61N1/00 ,  A61N1/05 ,  A61N1/36

    CPC classification number: A61N1/36167 ,  A61N1/0551

    Abstract: A system (1) for electrically stimulating a nerve (3), the system comprising: a first stimulator (5) and a second stimulator (7) for electrically stimulating the nerve, the first stimulator and the second stimulator spaced apart from one another by a first distance; and a controller (9) arranged to: a) set a time interval as a function of the first distance and the speed of propagation of an action potential in the nerve; b) activate the first stimulator for a first stimulation period, thus inducing electrical activity in the nerve; and c) activate the second stimulator for a second stimulation period after the time interval has elapsed after the end of the first time period. Preferably, the time interval is a sum of the first time period and a buffer time period for allowing the nerve to recover from stimulation.

    NEUROSTIMULATION DEVICE FOR BLOCKING BLOOD FLOW BETWEEN ELECTRODES
    20.
    发明申请
    NEUROSTIMULATION DEVICE FOR BLOCKING BLOOD FLOW BETWEEN ELECTRODES 有权

    公开(公告)号：US20220347470A1

    公开(公告)日：2022-11-03

    申请号：US17415592

    申请日：2019-12-16

    Applicant: Galvani Bioelectronics Limited

    Inventor： Christopher Shen-Yuan Lai ,  Kenneth Douglas Rys ,  Matteo Donega ,  Isha Gupta

    IPC: A61N1/36

    Abstract: A neurostimulation device 1 for non-destructively stimulating neural activity in a nerve 3 in proximity to a blood vessel 5. The neurostimulation device 1 comprises a catheter 7 for insertion into the blood vessel 5; a proximal electrode 11 offset from a distal electrode 9 along a length of the catheter 7; and an insulator 13 positioned between the proximal electrode 11 and the distal electrode 9 on the catheter 7. The insulator 13 has a contracted configuration in which the size of the insulator 13 allows the catheter 7 to travel inside the blood vessel 5. The insulator 13 has an expanded configuration in which the insulator 13 blocks blood flowing through the blood vessel between the proximal electrode 11 and the distal electrode 9. The neurostimulation device 1 comprises a stimulator 15 arranged to apply an electrical signal between the proximal electrode 11 and the distal electrode 9 when the insulator 13 is in the expanded configuration, thus inducing electrical activity in a wall portion of the blood vessel between the proximal and distal electrodes 9, 11. There is also an insulation portion between the distal electrode 9 and a distal end of the catheter 7 for offsetting the distal electrode 9 from a wall of the blood vessel 5.

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