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公开(公告)号：US20060205762A1
公开(公告)日：2006-09-14
申请号：US11435999
申请日：2006-05-17
申请人： Han-Cheng Zhang , Gee-Hong Kuo , Bruce Maryanoff , Hong Ye , David O'Neill , Lan Shen , Keith Demarest , Bruce Conway , David McComsey
发明人： Han-Cheng Zhang , Gee-Hong Kuo , Bruce Maryanoff , Hong Ye , David O'Neill , Lan Shen , Keith Demarest , Bruce Conway , David McComsey
IPC分类号： C07D471/02 , A61K31/4745
CPC分类号： C07D471/04
摘要： The present invention is directed to novel substituted pyrroline compounds useful as kinase inhibitors and methods for treating or ameliorating a kinase mediated disorder.
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公开(公告)号：US07125878B2
公开(公告)日：2006-10-24
申请号：US10430000
申请日：2003-05-06
申请人： Han-Cheng Zhang , Gee-Hong Kuo , Bruce E. Maryanoff , Hong Ye , David O'Neill , Lan Shen , Keith Demarest , Bruce R. Conway , David F. McComsey
发明人： Han-Cheng Zhang , Gee-Hong Kuo , Bruce E. Maryanoff , Hong Ye , David O'Neill , Lan Shen , Keith Demarest , Bruce R. Conway , David F. McComsey
IPC分类号： A61K31/495 , C07D241/02 , C07D403/04
CPC分类号： C07D471/04
摘要： The present invention is directed to novel substituted pyrroline compounds useful as kinase inhibitors and methods for treating or ameliorating a kinase mediated disorder.
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公开(公告)号：US20060205763A1
公开(公告)日：2006-09-14
申请号：US11436000
申请日：2006-05-17
申请人： Han-Cheng Zhang , Gee-Hong Kuo , Bruce Maryanoff , Hong Ye , David O'Neill , Lan Shen , Keith Demarest , Bruce Conway , David McComsey
发明人： Han-Cheng Zhang , Gee-Hong Kuo , Bruce Maryanoff , Hong Ye , David O'Neill , Lan Shen , Keith Demarest , Bruce Conway , David McComsey
IPC分类号： A61K31/4745 , C07D471/02
CPC分类号： C07D471/04
摘要： The present invention is directed to novel substituted pyrroline compounds useful as kinase inhibitors and methods for treating or ameliorating a kinase mediated disorder.
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公开(公告)号：US07786135B2
公开(公告)日：2010-08-31
申请号：US11436000
申请日：2006-05-17
申请人： Han-Cheng Zhang , Gee-Hong Kuo , Bruce E. Maryanoff , Hong Ye , David O'Neill , Lan Shen , Keith Demarest , Bruce R. Conway , David F. McComsey
发明人： Han-Cheng Zhang , Gee-Hong Kuo , Bruce E. Maryanoff , Hong Ye , David O'Neill , Lan Shen , Keith Demarest , Bruce R. Conway , David F. McComsey
IPC分类号： A61K31/437 , A61K31/4353 , A61K31/407
CPC分类号： C07D471/04
摘要： The present invention is directed to novel substituted pyrroline compounds useful as kinase inhibitors and methods for treating or ameliorating a kinase mediated disorder.
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公开(公告)号：US20090181982A1
公开(公告)日：2009-07-16
申请号：US12401764
申请日：2009-03-11
申请人： Han-Cheng Zhang , Gee-Hong Kuo , Bruce E. Maryanoff , Hong Ye , David O'Neill , Lan Shen , Keith Demarest , Bruce R. Conway , David F. McComsey
发明人： Han-Cheng Zhang , Gee-Hong Kuo , Bruce E. Maryanoff , Hong Ye , David O'Neill , Lan Shen , Keith Demarest , Bruce R. Conway , David F. McComsey
IPC分类号： A61K31/437 , C07D471/04 , A61K31/497 , A61K31/506
CPC分类号： C07D471/04
摘要： The present invention is directed to novel substituted pyrroline compounds useful as kinase inhibitors and methods for treating or ameliorating a kinase mediated disorder.
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公开(公告)号：US20090176806A1
公开(公告)日：2009-07-09
申请号：US12401777
申请日：2009-03-11
申请人： Han-Cheng Zhang , Gee-Hong Kuo , Bruce E. Maryanoff , Hong Ye , David O'Neill , Lan Shen , Keith Demarest , Bruce R. Conway , David F. McComsey
发明人： Han-Cheng Zhang , Gee-Hong Kuo , Bruce E. Maryanoff , Hong Ye , David O'Neill , Lan Shen , Keith Demarest , Bruce R. Conway , David F. McComsey
IPC分类号： A61K31/497 , C07D403/14 , A61K31/437 , C07D405/14 , C07D409/14 , C07D413/14 , A61K31/506
CPC分类号： C07D471/04
摘要： The present invention is directed to novel substituted pyrroline compounds useful as kinase inhibitors and methods for treating or ameliorating a kinase mediated disorder.
摘要翻译： 本发明涉及用作激酶抑制剂的新型取代的吡咯啉化合物和用于治疗或改善激酶介导的病症的方法。
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公开(公告)号：US20080176912A1
公开(公告)日：2008-07-24
申请号：US11939039
申请日：2007-11-13
申请人： Gee-Hong Kuo , Fengbin Song , Joseph Gunnet , Keith Demarest
发明人： Gee-Hong Kuo , Fengbin Song , Joseph Gunnet , Keith Demarest
IPC分类号： A61K31/426 , A61K31/421 , A61K31/34 , A61K31/381 , A61K31/192 , C07D333/24 , C07D277/22 , C07D263/30
CPC分类号： C07D333/24 , C07C59/64 , C07C59/72
摘要： The invention is directed to compounds of Formula (I) useful as GPR40 agonists. Pharmaceutical compositions and methods of treating one or more conditions including, but not limited to, insulin resistance, hyperglycemia, obesity, diabetes such as NIDDM, and other disorders related to lipid metabolism, energy homeostasis, and complications thereof, using compounds of the invention are also described.
摘要翻译： 本发明涉及用作GPR40激动剂的式（I）化合物。 使用本发明化合物治疗一种或多种病症的药物组合物和方法，包括但不限于胰岛素抵抗，高血糖症，肥胖症，糖尿病如NIDDM，以及与脂质代谢相关的其它障碍，能量稳态及其并发症， 也描述。
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公开(公告)号：US20060074130A1
公开(公告)日：2006-04-06
申请号：US11145119
申请日：2005-06-03
申请人： Xiaoli Chen , Keith Demarest , Jung Lee , Jay Matthews , Philip Rybczynski
发明人： Xiaoli Chen , Keith Demarest , Jung Lee , Jay Matthews , Philip Rybczynski
IPC分类号： A61K31/195 , C07C335/20 , C07C317/38
CPC分类号： C07C323/52 , C07C323/44 , C07C2602/08 , C07C2602/10
摘要： The invention features tetralin and indane compounds, compositions containing them, and methods of using them as PPAR alpha modulators to treat or inhibit the progression of, for example, diabetes.
摘要翻译： 本发明具有四氢化萘和二氢化茚化合物，含有它们的组合物，以及使用它们作为PPARα调节剂来治疗或抑制例如糖尿病进展的方法。
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公开(公告)号：US06987110B2
公开(公告)日：2006-01-17
申请号：US10454069
申请日：2003-06-04
IPC分类号： A61K31/497 , A61K31/47 , C07D401/00
CPC分类号： C07D401/14 , C07D403/14 , C07D409/14
摘要： The present invention is directed to novel substituted pyrroline compounds useful as kinase or dual-kinase inhibitors, methods for producing such compounds and methods for treating or ameliorating a kinase or dual-kinase mediated disorder.
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公开(公告)号：US5532226A
公开(公告)日：1996-07-02
申请号：US164602
申请日：1993-12-09
申请人： Keith Demarest , Charles Schwender , David Wustrow
发明人： Keith Demarest , Charles Schwender , David Wustrow
IPC分类号： A61K31/66 , A61P3/00 , C07F9/38 , C07F9/40 , C07F9/6533 , C07F9/02 , C07D279/12 , C07F9/28
CPC分类号： C07F9/6533 , C07F9/3882 , C07F9/4056
摘要： Novel benzylphosphonate compounds of the general formula I: ##STR1## are disclosed as useful in treating bone wasting diseases including postmenopausal osteoporosis in increasing in mammals bone formation and bone mass.
摘要翻译： 公开了通式I的新型苄基膦酸酯化合物：其用于治疗骨质疏松疾病，包括绝经后骨质疏松症，以增加哺乳动物的骨形成和骨量。
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