公开(公告)号：US07781450B2

公开(公告)日：2010-08-24

申请号：US12401777

申请日：2009-03-11

Applicant: Han-Cheng Zhang ,  Gee-Hong Kuo ,  Bruce E. Maryanoff ,  Hong Ye ,  David O'Neill ,  Lan Shen ,  Keith Demarest ,  Bruce R. Conway ,  David F. McComsey

Inventor： Han-Cheng Zhang ,  Gee-Hong Kuo ,  Bruce E. Maryanoff ,  Hong Ye ,  David O'Neill ,  Lan Shen ,  Keith Demarest ,  Bruce R. Conway ,  David F. McComsey

IPC: A61K31/4353 ,  A61K31/437 ,  C07D471/02

CPC classification number: C07D471/04

Abstract: The present invention is directed to novel substituted pyrroline compounds useful as kinase inhibitors and methods for treating or ameliorating a kinase mediated disorder.

公开(公告)号：US07750048B2

公开(公告)日：2010-07-06

申请号：US11939039

申请日：2007-11-13

Applicant: Gee-Hong Kuo ,  Fengbin Song ,  Joseph Gunnet ,  Keith Demarest

Inventor： Gee-Hong Kuo ,  Fengbin Song ,  Joseph Gunnet ,  Keith Demarest

IPC: A61K31/192 ,  C07C59/64

CPC classification number: C07D333/24 ,  C07C59/64 ,  C07C59/72

Abstract: The invention is directed to compounds of Formula (I) useful as GPR40 agonists. Pharmaceutical compositions and methods of treating one or more conditions including, but not limited to, insulin resistance, hyperglycemia, obesity, diabetes such as NIDDM, and other disorders related to lipid metabolism, energy homeostasis, and complications thereof, using compounds of the invention are also described.

Abstract translation: 本发明涉及用作GPR40激动剂的式（I）化合物。 使用本发明化合物治疗一种或多种病症的药物组合物和方法，包括但不限于胰岛素抵抗，高血糖症，肥胖症，糖尿病如NIDDM，以及与脂质代谢相关的其它障碍，能量稳态及其并发症， 也描述。

公开(公告)号：US20060074130A1

公开(公告)日：2006-04-06

申请号：US11145119

申请日：2005-06-03

Applicant: Xiaoli Chen ,  Keith Demarest ,  Jung Lee ,  Jay Matthews ,  Philip Rybczynski

Inventor： Xiaoli Chen ,  Keith Demarest ,  Jung Lee ,  Jay Matthews ,  Philip Rybczynski

IPC: A61K31/195 ,  C07C335/20 ,  C07C317/38

CPC classification number: C07C323/52 ,  C07C323/44 ,  C07C2602/08 ,  C07C2602/10

Abstract: The invention features tetralin and indane compounds, compositions containing them, and methods of using them as PPAR alpha modulators to treat or inhibit the progression of, for example, diabetes.

Abstract translation: 本发明具有四氢化萘和二氢化茚化合物，含有它们的组合物，以及使用它们作为PPARα调节剂来治疗或抑制例如糖尿病进展的方法。

公开(公告)号：US06987110B2

公开(公告)日：2006-01-17

申请号：US10454069

申请日：2003-06-04

Applicant: Han-Cheng Zhang ,  Bruce E. Maryanoff ,  Hong Ye ,  Bruce R. Conway ,  Keith Demarest

Inventor： Han-Cheng Zhang ,  Bruce E. Maryanoff ,  Hong Ye ,  Bruce R. Conway ,  Keith Demarest

IPC: A61K31/497 ,  A61K31/47 ,  C07D401/00

CPC classification number: C07D401/14 ,  C07D403/14 ,  C07D409/14

Abstract: The present invention is directed to novel substituted pyrroline compounds useful as kinase or dual-kinase inhibitors, methods for producing such compounds and methods for treating or ameliorating a kinase or dual-kinase mediated disorder.

公开(公告)号：US5532226A

公开(公告)日：1996-07-02

申请号：US164602

申请日：1993-12-09

Applicant: Keith Demarest ,  Charles Schwender ,  David Wustrow

Inventor： Keith Demarest ,  Charles Schwender ,  David Wustrow

IPC: A61K31/66 ,  A61P3/00 ,  C07F9/38 ,  C07F9/40 ,  C07F9/6533 ,  C07F9/02 ,  C07D279/12 ,  C07F9/28

CPC classification number: C07F9/6533 ,  C07F9/3882 ,  C07F9/4056

Abstract: Novel benzylphosphonate compounds of the general formula I: ##STR1## are disclosed as useful in treating bone wasting diseases including postmenopausal osteoporosis in increasing in mammals bone formation and bone mass.

Abstract translation: 公开了通式I的新型苄基膦酸酯化合物：其用于治疗骨质疏松疾病，包括绝经后骨质疏松症，以增加哺乳动物的骨形成和骨量。

公开(公告)号：US5300687A

公开(公告)日：1994-04-05

申请号：US732267

申请日：1991-07-18

Applicant: Charles Schwender ,  Keith Demarest ,  David Wustrow

Inventor： Charles Schwender ,  Keith Demarest ,  David Wustrow

IPC: A61K31/66 ,  A61P3/00 ,  C07F9/38 ,  C07F9/40 ,  C07F9/6533 ,  C07F9/02 ,  C07D265/30 ,  C07D279/12 ,  C07F9/28

CPC classification number: C07F9/6533 ,  C07F9/3882 ,  C07F9/4056

Abstract: Novel benzylphosphonate compounds of the general formula I: ##STR1## are disclosed as useful in treating bone wasting diseases including postmenopausal osteoporosis in increasing in mammals bone formation and bone mass.

Abstract translation: 公开了通式I的新型苄基膦酸盐化合物：（*化学结构*）I可用于治疗哺乳动物骨形成和骨量增加中包括绝经后骨质疏松症的骨消耗疾病。

公开(公告)号：US20100240650A1

公开(公告)日：2010-09-23

申请号：US12787034

申请日：2010-05-25

Applicant: Han-Cheng Zhang ,  Bruce E. Maryanoff ,  David F. McComsey ,  Kimberly White ,  Hong Ye ,  Leonard R. Hecker ,  Bruce Conway ,  Keith Demarest

Inventor： Han-Cheng Zhang ,  Bruce E. Maryanoff ,  David F. McComsey ,  Kimberly White ,  Hong Ye ,  Leonard R. Hecker ,  Bruce Conway ,  Keith Demarest

IPC: A61K31/5377 ,  C07D403/04 ,  A61K31/404 ,  A61P3/10 ,  A61P9/00 ,  A61P29/00 ,  A61P37/00 ,  A61P17/00 ,  A61P27/02 ,  A61P25/00 ,  C07D401/14 ,  A61K31/4439 ,  C07D403/14 ,  A61K31/496 ,  C07D413/14 ,  A61K31/506 ,  A61K31/416

CPC classification number: C07D409/14 ,  C07D401/14 ,  C07D403/04 ,  C07D403/14 ,  C07D405/14 ,  C07D417/14

Abstract: The present invention is directed to novel substituted pyrroline compounds useful as kinase or dual-kinase inhibitors, methods for producing such compounds and methods for treating or ameliorating a kinase or dual-kinase mediated disorder.

Abstract translation: 本发明涉及用作激酶或双重激酶抑制剂的新型取代的吡咯啉化合物，用于制备这些化合物的方法和用于治疗或改善激酶或双重激酶介导的病症的方法。

公开(公告)号：US07786135B2

公开(公告)日：2010-08-31

申请号：US11436000

申请日：2006-05-17

Applicant: Han-Cheng Zhang ,  Gee-Hong Kuo ,  Bruce E. Maryanoff ,  Hong Ye ,  David O'Neill ,  Lan Shen ,  Keith Demarest ,  Bruce R. Conway ,  David F. McComsey

Inventor： Han-Cheng Zhang ,  Gee-Hong Kuo ,  Bruce E. Maryanoff ,  Hong Ye ,  David O'Neill ,  Lan Shen ,  Keith Demarest ,  Bruce R. Conway ,  David F. McComsey

IPC: A61K31/437 ,  A61K31/4353 ,  A61K31/407

CPC classification number: C07D471/04

Abstract: The present invention is directed to novel substituted pyrroline compounds useful as kinase inhibitors and methods for treating or ameliorating a kinase mediated disorder.

公开(公告)号：US07608634B2

公开(公告)日：2009-10-27

申请号：US11800912

申请日：2007-05-08

Applicant: Han-Cheng Zhang ,  Bruce E. Maryanoff ,  David F. McComsey ,  Kimberly White ,  Hong Ye ,  Leonard R. Hecker ,  Bruce Conway ,  Keith Demarest

Inventor： Han-Cheng Zhang ,  Bruce E. Maryanoff ,  David F. McComsey ,  Kimberly White ,  Hong Ye ,  Leonard R. Hecker ,  Bruce Conway ,  Keith Demarest

IPC: A61K31/415 ,  A61K31/40

CPC classification number: C07D409/14 ,  C07D401/14 ,  C07D403/04 ,  C07D403/14 ,  C07D405/14 ,  C07D417/14

Abstract: The present invention is directed to novel substituted pyrroline compounds useful as kinase or dual-kinase inhibitors, methods for producing such compounds and methods for treating or ameliorating a kinase or dual-kinase mediated disorder.

Abstract translation: 本发明涉及用作激酶或双重激酶抑制剂的新型取代的吡咯啉化合物，用于制备这些化合物的方法以及用于治疗或改善激酶或双重激酶介导的病症的方法。

公开(公告)号：US07598416B2

公开(公告)日：2009-10-06

申请号：US12144061

申请日：2008-06-23

Applicant: Gee-Hong Kuo ,  Rui Zhang ,  Aihua Wang ,  Alan DeAngelis ,  Keith Demarest ,  Patricia Pelton

Inventor： Gee-Hong Kuo ,  Rui Zhang ,  Aihua Wang ,  Alan DeAngelis ,  Keith Demarest ,  Patricia Pelton

IPC: C07C59/13 ,  C07C53/134 ,  C07C255/00 ,  A61K31/275 ,  A61K31/20 ,  A61K31/195

CPC classification number: C07C59/68 ,  C07C323/20

Abstract: The invention features 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs, compositions containing them, and methods of using them as PPAR modulators to treat or inhibit the progression of, for example, dyslipidemia.

Abstract translation: 本发明具有4 - （（苯氧基烷基）硫基） - 苯氧基乙酸及其类似物，含有它们的组合物，以及使用它们作为PPAR调节剂来治疗或抑制例如血脂异常进展的方法。