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公开(公告)号：US09486546B2
公开(公告)日：2016-11-08
申请号：US14814734
申请日：2015-07-31
Applicant: Genentech, Inc.
Inventor： Charles Andrew Boswell , Leslie A. Khawli , Jan Marik , Simon Williams
IPC: A61K49/16 , A61K51/04 , C07K16/28 , C07K5/02 , A61K51/08 , A61K51/10 , C07B59/00 , C07D207/404 , C07D207/452
CPC classification number: A61K49/16 , A61K51/0482 , A61K51/08 , A61K51/088 , A61K51/103 , A61K51/1051 , A61K51/1093 , C07B59/002 , C07D207/404 , C07D207/452 , C07K1/13 , C07K5/02 , C07K16/28
Abstract: Methods and compositions are provided for labeling proteins with radiohalogen-label reagents. Radiohalogen-labeled proteins may be used for imaging studies, as therapeutics and in diagnostic tests. The [125I] HIP-DOTA label reagent 6 is prepared by an efficient and convenient process.
Abstract translation: 提供了用放射性卤素标记试剂标记蛋白质的方法和组合物。 放射性卤素标记的蛋白质可用作成像研究，作为治疗剂和诊断测试。 [125I] HIP-DOTA标签试剂6通过有效和方便的方法制备。
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公开(公告)号：US09393327B2
公开(公告)日：2016-07-19
申请号：US14132252
申请日：2013-12-18
Applicant: Genentech, Inc.
Inventor： Charles Andrew Boswell , Leslie A Khawli , Jan Marik , Simon Williams
CPC classification number: A61K49/16 , A61K51/0482 , A61K51/08 , A61K51/088 , A61K51/103 , A61K51/1051 , A61K51/1093 , C07B59/002 , C07D207/404 , C07D207/452 , C07K1/13 , C07K5/02 , C07K16/28
Abstract: Methods and compositions are provided for labeling proteins with radiohalogen-label reagents. Radiohalogen-labeled proteins may be used for imaging studies, as therapeutics and in diagnostic tests. The [125I] HIP-DOTA label reagent 6 is prepared by an efficient and convenient process.
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13.发明申请公开(公告)号：US20150056132A1
公开(公告)日：2015-02-26
申请号：US14287826
申请日：2014-05-27
Applicant: Genentech, Inc.
Inventor： Mark DENNIS , Jan Marik , Paul Polakis , Bonnee Rubinfeld , Simon Williams
CPC classification number: C07K16/40 , A61K47/6811 , A61K47/6871 , A61K51/1072 , A61K51/1075 , A61K51/1093 , A61K51/1096 , A61K2039/505 , C07B59/008 , C07B2200/05 , C07K16/3069 , C07K2317/24 , C07K2317/565 , C07K2317/92 , G01N33/534 , G01N33/57492 , G01N33/60 , G01N33/6893
Abstract: Anti-STEAP-1 antibodies and immunoconjugates thereof are provided. Methods of using anti-STEAP-1 antibodies and immunoconjugates thereof are provided. Methods of detecting or determining the presence of STEAP-1 proteins are provided.
Abstract translation: 提供抗STEAP-1抗体及其免疫偶联物。 提供了使用抗STEAP-1抗体及其免疫偶联物的方法。 提供检测或确定STEAP-1蛋白存在的方法。
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公开(公告)号：US20130157289A1
公开(公告)日：2013-06-20
申请号：US13692888
申请日：2012-12-03
Applicant: Genentech, Inc.
Inventor： Mark Dennis , Jan Marik , Paul Polakis , Bonnee Rubinfeld , Simon Williams
CPC classification number: C07K16/40 , A61K47/6811 , A61K47/6871 , A61K51/1072 , A61K51/1075 , A61K51/1093 , A61K51/1096 , A61K2039/505 , C07B59/008 , C07B2200/05 , C07K16/3069 , C07K2317/24 , C07K2317/565 , C07K2317/92 , G01N33/534 , G01N33/57492 , G01N33/60 , G01N33/6893
Abstract: Anti-STEAP-1 antibodies and immunoconjugates thereof are provided. Methods of using anti-STEAP-1 antibodies and immunoconjugates thereof are provided. Methods of detecting or determining the presence of STEAP-1 proteins are provided.
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Patent Agency Ranking
公开(公告)号：US20200297875A1
公开(公告)日：2020-09-24
申请号：US16895352
申请日：2020-06-08
Applicant: Genentech, Inc.
Inventor： Jan Marik , Joseph P. Lyssikatos , Simon Williams
IPC: A61K51/04 , C07B59/00 , C07D487/04
Abstract: The present invention relates to deuterated and optionally detectably labeled compounds of formula (I) and formula (V): and salts thereof, wherein R1, R2, A, and X10-X19 have any of the values defined in the specification. Also included are pharmaceutical compositions comprising such compounds and salts, and methods of using such compounds and salts as imaging agents.
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公开(公告)号：US10076581B2
公开(公告)日：2018-09-18
申请号：US15006997
申请日：2016-01-26
Applicant: Genentech, Inc.
Inventor： Jan Marik , Joseph P. Lyssikatos , Simon Williams
IPC: A61K51/04 , C07B59/00 , C07D487/04
Abstract: The present invention relates to deuterated and optionally detectably labeled compounds of formula (I) and formula (V): and salts thereof, wherein R1, R2, A, and X10-X19 have any of the values defined in the specification. Also included are pharmaceutical compositions comprising such compounds and salts, and methods of using such compounds and salts as imaging agents.
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公开(公告)号：US20160250358A1
公开(公告)日：2016-09-01
申请号：US15006997
申请日：2016-01-26
Applicant: Genentech, Inc.
Inventor： Jan Marik , Joseph P. Lyssikatos , Simon Williams
IPC: A61K51/04 , C07D487/04 , C07B59/00
CPC classification number: A61K51/0459 , C07B59/002 , C07B2200/05 , C07D487/04
Abstract: The present invention relates to deuterated and optionally detectably labeled compounds of formula (I) and formula (V): and salts thereof, wherein R1, R2, A, and X10-X19 have any of the values defined in the specification. Also included are pharmaceutical compositions comprising such compounds and salts, and methods of using such compounds and salts as imaging agents.
Abstract translation: 本发明涉及氘化和任选可检测地标记的式（I）和式（Ⅴ）化合物及其盐，其中R1，R2，A和X10-X19具有说明书中定义的任何值。 还包括包含这些化合物和盐的药物组合物，以及使用这些化合物和盐作为成像剂的方法。
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18.发明授权Fluorine-18 and carbon-11 labeled radioligands for positron emission tomography (PET) imaging for LRRK2 有权氟-18和碳-11标记的放射性配体用于LRRK2的正电子发射断层扫描（PET）成像公开(公告)号：US09139566B2
公开(公告)日：2015-09-22
申请号：US13687441
申请日：2012-11-28
Applicant: Genentech, Inc.
Inventor： Jan Marik , Zachary Kevin Sweeney , Bryan K. Chan , Anthony Estrada
IPC: A61K51/00 , A61M36/14 , C07D403/12 , A61K51/04 , C07D239/48
CPC classification number: C07D403/12 , A61K51/0453 , A61K51/0455 , A61K51/0459 , C07D239/48
Abstract: A method for positron emission tomography (PET) imaging of LRRK2 in tissue of a subject, the method comprising: administering a compound of formula I, formula II or formula III, or a pharmaceutically acceptable salt thereof to the subject, wherein the compound includes at least one C11 or F18 label thereon; allowing the compound to penetrate into the tissue of the subject; and collecting a PET image of the CNS or brain tissue of the subject.
Abstract translation: 一种用于受试者组织中LRRK2的正电子发射断层摄影（PET）成像的方法，所述方法包括：向受试者施用式I，式II或式III化合物或其药学上可接受的盐，其中所述化合物包括 在其上至少有一个C11或F18标签; 允许化合物渗透到受试者的组织中; 并收集受试者的CNS或脑组织的PET图像。
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公开(公告)号：US20140170064A1
公开(公告)日：2014-06-19
申请号：US14132252
申请日：2013-12-18
Applicant: Genentech, Inc.
Inventor： Charles Andrew Boswell , Leslie A. Khawli , Jan Marik , Simon Williams
CPC classification number: A61K49/16 , A61K51/0482 , A61K51/08 , A61K51/088 , A61K51/103 , A61K51/1051 , A61K51/1093 , C07B59/002 , C07D207/404 , C07D207/452 , C07K1/13 , C07K5/02 , C07K16/28
Abstract: Methods and compositions are provided for labeling proteins with radiohalogen-label reagents. Radiohalogen-labeled proteins may be used for imaging studies, as therapeutics and in diagnostic tests. The [125I] HIP-DOTA label reagent 6 is prepared by an efficient and convenient process.
Abstract translation: 提供了用放射性卤素标记试剂标记蛋白质的方法和组合物。 放射性卤素标记的蛋白质可用作成像研究，作为治疗剂和诊断测试。 [125I] HIP-DOTA标签试剂6通过有效和方便的方法制备。
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