公开(公告)号：US20190119274A1

公开(公告)日：2019-04-25

申请号：US16221274

申请日：2018-12-14

Applicant: Genentech, Inc.

Inventor： James John Crawford ,  Aleksandr Kolesnikov ,  Jianwen A. Feng

IPC: C07D471/04 ,  C07D417/10

Abstract: The invention relates to compounds of formula (I): wherein Q, A1, A2, A3, A5, A6, A7, A8, R4a, R4b and R5 are as described herein. Compounds of formula (I) and pharmaceutical compositions thereof are useful in the treatment of diseases and disorders in which undesired or over-activation of NF-kB signaling is observed.

公开(公告)号：US20160185797A1

公开(公告)日：2016-06-30

申请号：US15060325

申请日：2016-03-03

Applicant: Genentech, Inc.

Inventor： Nicole Blaquiere ,  Georgette Castanedo ,  Jianwen A. Feng ,  Baihua Hu ,  Steven Staben ,  Po-wai Yuen ,  Guosheng Wu ,  Xingyu Lin ,  Jason Burch

IPC: C07D495/04 ,  C07D403/10 ,  C07D403/14 ,  C07D491/107 ,  C07D409/14 ,  C07D417/14 ,  C07D487/04 ,  C07D401/14 ,  C07D471/04 ,  C07D413/10 ,  C07D405/10 ,  C07D401/10 ,  C07D405/14

CPC classification number: C07D401/10 ,  A61K31/395 ,  C07D401/14 ,  C07D403/10 ,  C07D403/14 ,  C07D405/10 ,  C07D405/14 ,  C07D409/14 ,  C07D413/10 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D491/048 ,  C07D491/107 ,  C07D495/04 ,  C07D495/06

Abstract: The invention relates to compounds of Formula (0): wherein A1-A8, R4 and R5 each has the meaning as described herein. Compounds of Formula (0) and pharmaceutical compositions thereof are useful in the treatment of diseases and disorders in which undesired or over-activation of NF-kB signaling is observed.