公开(公告)号：US20220106322A1

公开(公告)日：2022-04-07

申请号：US17644742

申请日：2021-12-16

Applicant: Genentech, Inc.

Inventor： Mark Edward Zak ,  Naomi S. Rajapaksa ,  Yun-Xing Cheng ,  Wei Li ,  Daniel G.M. Shore ,  F. Anthony Romero ,  Marian C. Bryan

IPC: C07D487/04 ,  C07D519/00

Abstract: Compounds and salts thereof that are useful as JAK kinase inhibitors are described herein. Also provided are pharmaceutical compositions that include such a JAK inhibitor and a pharmaceutically acceptable carrier, adjuvant or vehicle, and methods of treating or lessening the severity of a disease or condition responsive to the inhibition of a Janus kinase activity in a patient.

公开(公告)号：US10899774B2

公开(公告)日：2021-01-26

申请号：US16715959

申请日：2019-12-16

Applicant: Genentech, Inc.

Inventor： Marian C. Bryan ,  Joy Drobnick ,  Alberto Gobbi ,  Tamiko Katsumoto ,  Naomi S. Rajapaksa ,  James Richard Kiefer, Jr.

IPC: C07D498/04 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D491/048 ,  C07D495/04 ,  C07D513/04

Abstract: Compounds of Formula 0, and stereoisomers and pharmaceutically acceptable salts thereof, as well as methods of use as Interleukin-1 Receptor Associated Kinase (IRAK4) inhibitors are described herein.

公开(公告)号：US10899772B2

公开(公告)日：2021-01-26

申请号：US16715997

申请日：2019-12-16

Applicant: Genentech, Inc.

Inventor： Marian C. Bryan ,  Steven Do ,  Tamiko Katsumoto ,  Jun Liang ,  Naomi S. Rajapaksa ,  James Richard Kiefer, Jr. ,  Liqiang Fu

IPC: C07D487/04 ,  C07D413/14 ,  C07D471/04 ,  C07D495/04

Abstract: Compounds of Formula 0, and stereoisomers and pharmaceutically acceptable salts thereof, as well as methods of use as Interleukin-1 Receptor Associated Kinase (IRAK4) inhibitors are described herein.

公开(公告)号：US20180298015A1

公开(公告)日：2018-10-18

申请号：US16014231

申请日：2018-06-21

Applicant: Genentech, Inc.

Inventor： Marian C. Bryan ,  Alberto Gobbi ,  James Richard Kiefer, JR. ,  Aleksandr Kolesnikov ,  Alan G. Olivero ,  Joy Drobnick ,  Jun Liang ,  Naomi Rajapaksa ,  Chudi Ndubaku ,  Jianwen Feng

IPC: C07D487/04 ,  C07D519/00 ,  A61P29/00 ,  A61P35/00 ,  A61P37/02

Abstract: Compounds of Formula 0, Formula I, and Formula II and methods of use as Interleukin-1 Receptor Associated Kinase (IRAK4) inhibitors are described herein.

公开(公告)号：US09890152B2

公开(公告)日：2018-02-13

申请号：US14745159

申请日：2015-06-19

Applicant: Genentech, Inc.

Inventor： Marian C. Bryan ,  Bryan Chan ,  Emily Hanan ,  Timothy Heffron ,  Hans Purkey ,  Richard Leonard Elliott ,  Robert Heald ,  Jamie Knight ,  Michael Lainchbury ,  Eileen M. Seward

IPC: C07D471/04 ,  C07D498/10 ,  A61K31/506 ,  A61K31/5377 ,  C07D498/08 ,  A61K31/541 ,  A61K31/538 ,  C07D491/107 ,  C07D519/00 ,  A61K31/5355 ,  A61K45/06

CPC classification number: C07D471/04 ,  A61K31/506 ,  A61K31/5355 ,  A61K31/5377 ,  A61K31/538 ,  A61K31/541 ,  A61K45/06 ,  C07D491/107 ,  C07D498/08 ,  C07D498/10 ,  C07D519/00

Abstract: This invention relates to novel compounds which are inhibitors of T790M containing EGFR mutants, to pharmaceutical compositions containing them, to processes for their preparation, and to their use in therapy for the prevention or treatment of cancer.