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公开(公告)号：US20200165260A1
公开(公告)日：2020-05-28
申请号：US16777049
申请日：2020-01-30
Applicant: Genentech, Inc.
Inventor： Yun-Xing Cheng , Paul Gibbons , Terry Kellar , Wei Li , Rohan Mendonca , Po-wai Yuen , Mark Edward Zak , Lei Zhang
IPC: C07D487/04 , C07D519/00
Abstract: Compounds of Formula (00A) and salts thereof, wherein R1, R2 R3, R4 and n are defined herein, are useful as inhibitors of one or more Janus kinases. Also provided are pharmaceutical compositions that include a compound of Formula (00A) and a pharmaceutically acceptable carrier, adjuvant or vehicle, and methods of treating or lessening the severity of a disease or condition responsive to the inhibition of a Janus kinase activity in a patient.
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12.发明申请公开(公告)号：US20180305355A1
公开(公告)日：2018-10-25
申请号：US15820515
申请日：2017-11-22
Applicant: Genentech, Inc.
Inventor： Mark Edward Zak , Nicholas Charles Ray , Simon Charles Goodacre , Rohan Mendonca , Terry Kellar , Yun-Xing Cheng , Wei Li , Po-wai Yuen
IPC: C07D471/04 , C07D487/04 , A61K31/519 , C07D519/00
CPC classification number: C07D471/04 , A61K31/519 , C07D487/04 , C07D519/00
Abstract: Compounds of Formula (00A) and methods of use as Janus kinase inhibitors are described herein.
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13.发明授权5-chloro-2-difluoromethoxyphenyl pyrazolopyrimidine compounds, compositions and methods of use thereof 有权5-氯-2-二氟甲氧基苯基吡唑并嘧啶化合物，其组合物及其使用方法公开(公告)号：US09346815B2
公开(公告)日：2016-05-24
申请号：US14720323
申请日：2015-05-22
Applicant: Genentech, Inc.
Inventor： Mark Edward Zak , Nicholas Charles Ray , Simon Charles Goodacre , Rohan Mendonca , Terry Kellar , Yun-Xing Cheng , Wei Li , Po-Wai Yuen
IPC: C07D487/04 , A61K31/519 , A61P11/06 , C07D519/00
CPC classification number: C07D471/04 , A61K31/519 , C07D487/04 , C07D519/00
Abstract: Compounds of Formula (00A) and methods of use as Janus kinase inhibitors are described herein.
Abstract translation: 本文描述了式（00A）的化合物和用作Janus激酶抑制剂的方法。
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公开(公告)号：US11731943B2
公开(公告)日：2023-08-22
申请号：US17177356
申请日：2021-02-17
Applicant: Genentech, Inc.
Inventor： James John Crawford , Mark Zak , Terry Kellar , Yun-Xing Cheng , Wei Li , F. Anthony Romero , Paul Gibbons , Guiling Zhao , Gregory Hamilton , Simon Charles Goodacre
IPC: C07D231/40 , C07D401/04 , C07D401/14 , C07D403/08 , C07D405/04 , C07D405/12 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14
CPC classification number: C07D231/40 , C07D401/04 , C07D401/14 , C07D403/08 , C07D405/04 , C07D405/12 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14
Abstract: Compounds of Formula (I):
and salts thereof, and methods of use as Janus kinase inhibitors are described herein.-
公开(公告)号：US20210179564A1
公开(公告)日：2021-06-17
申请号：US17177356
申请日：2021-02-17
Applicant: Genentech, Inc.
Inventor： James John Crawford , Mark Zak , Terry Kellar , Yun-Xing Cheng , Wei Li , F. Anthony Romero , Paul Gibbons , Guiling Zhao , Gregory Hamilton , Simon Charles Goodacre
IPC: C07D231/40 , C07D401/14 , C07D401/04 , C07D403/08 , C07D405/04 , C07D405/12 , C07D409/14 , C07D405/14 , C07D417/14 , C07D413/14
Abstract: Compounds of Formula (I): and salts thereof, and methods of use as Janus kinase inhibitors are described herein.
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Patent Agency Ranking
公开(公告)号：US20190233441A1
公开(公告)日：2019-08-01
申请号：US16373435
申请日：2019-04-02
Applicant: Genentech, Inc.
Inventor： Nicholas C. Ray , Yun-Xing Cheng , Christine Edwards , Simon C. Goodacre , Wei Li , Snahel Patel , Matthew W. Cartwright , Mohammed Sajad , Po-wai Yuen , Mark E. Zak
IPC: C07D519/00 , C07D471/04
CPC classification number: C07D519/00 , C07D471/04
Abstract: Compounds of Formula 0, Formula I and Formula II and methods of use as Janus kinase inhibitors are described herein.
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公开(公告)号：US10307426B2
公开(公告)日：2019-06-04
申请号：US15984747
申请日：2018-05-21
Applicant: Genentech, Inc.
Inventor： Mark Zak , F. Anthony Romero , Yun-Xing Cheng
IPC: C07D487/04 , A61K31/519 , A61P11/06 , A61P29/00
Abstract: Compounds and salts thereof that are useful as JAK kinse inhibitors are described herein. Also provided are pharmaceutical compositions that include such a JAK inhibitor and a pharmaceutically acceptable carrier, adjuvant or vehicle, and methods of treating or lessening the severity of a disease or condition responsive to the inhibition of a Janus kinase activity in a patient.
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公开(公告)号：US20190071404A1
公开(公告)日：2019-03-07
申请号：US16181228
申请日：2018-11-05
Applicant: Genentech, Inc.
Inventor： James John Crawford , Mark Zak , Terry Kellar , Yun-Xing Cheng , Wei Li , F. Anthony Romero , Paul Gibbons , Guiling Zhao , Gregory Hamilton , Simon Charles Goodacre
IPC: C07D231/40 , C07D401/04 , C07D405/04 , C07D403/08 , C07D409/14 , C07D401/14 , C07D405/12
Abstract: Compounds of Formula (I): and salts thereof, and methods of use as Janus kinase inhibitors are described herein.
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公开(公告)号：US10189836B2
公开(公告)日：2019-01-29
申请号：US16009596
申请日：2018-06-15
Applicant: Genentech, Inc.
Inventor： Yun-Xing Cheng , Rongbao Hua , Terry Kellar , Wei Li , Paul Gibbons , Mark Edward Zak
IPC: C07D471/04 , C07D519/00 , A61P11/06
Abstract: Compounds of Formula (I) and methods of use as Janus kinase inhibitors are described herein.
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公开(公告)号：US09873709B2
公开(公告)日：2018-01-23
申请号：US15499662
申请日：2017-04-27
Applicant: Genentech, Inc.
Inventor： Nicholas C. Ray , Yun-Xing Cheng , Christine Edwards , Simon C. Goodacre , Wei Li , Snahel Patel , Matthew W. Cartwright , Mohammed Sajad , Po-wai Yuen , Mark E. Zak
IPC: C07D519/00 , C07D471/04
CPC classification number: C07D519/00 , C07D471/04
Abstract: Compounds of Formula 0, Formula I and Formula II and methods of use as Janus kinase inhibitors are described herein.
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