公开(公告)号：US20240262846A1

公开(公告)日：2024-08-08

申请号：US18573847

申请日：2022-04-25

申请人： LT MATERIALS CO., LTD.

发明人： Eui-Jeong CHOI ,  Young-Seok NO ,  Dong-Jun KIM

IPC分类号： C07D495/04 ,  C07D403/04 ,  C07D403/08 ,  C07D405/14 ,  C07D409/14 ,  C07D491/048 ,  H10K50/11 ,  H10K85/60

CPC分类号： C07D495/04 ,  C07D403/04 ,  C07D403/08 ,  C07D405/14 ,  C07D409/14 ,  C07D491/048 ,  H10K50/11 ,  H10K85/6572 ,  H10K85/6574 ,  H10K85/6576

摘要： The present specification relates to a heterocyclic compound, an organic light emitting device, and a composition for an organic material layer of an organic light emitting device.

公开(公告)号：US12018001B2

公开(公告)日：2024-06-25

申请号：US18056227

申请日：2022-11-16

申请人： Corcept Therapeutics Incorporated

发明人： Hazel Hunt ,  Damien Francis Philippe Crepin ,  Joseph Thomas Hill-Cousins ,  Thomas Matthew Baker ,  Lorna Duffy

IPC分类号： C07D239/54 ,  A61K31/50 ,  A61K31/505 ,  A61K31/513 ,  A61K47/20 ,  A61P1/16 ,  A61P25/18 ,  A61P35/00 ,  C07D401/08 ,  C07D401/10 ,  C07D401/14 ,  C07D403/08 ,  C07D403/10 ,  C07D405/08 ,  C07D405/10 ,  C07D417/04 ,  C07D417/08 ,  C07D471/04

CPC分类号： C07D239/54 ,  A61P1/16 ,  A61P35/00 ,  C07D401/08 ,  C07D401/14 ,  C07D403/08 ,  C07D405/08 ,  C07D417/08 ,  C07D471/04

摘要： The present invention provides a class of pyrimidinedione cyclohexenyl compounds and methods of using these compounds as glucocorticoid receptor modulators.

公开(公告)号：US12012411B2

公开(公告)日：2024-06-18

申请号：US17538532

申请日：2021-11-30

申请人： Katholieke Universiteit Leuven

发明人： Dorothée Bardiot ,  Gunter Carlens ,  Kai Dallmeier ,  Suzanne Kaptein ,  Michael McNaughton ,  Arnaud Marchand ,  Johan Neyts ,  Wim Smets ,  Mohamed Koukni

IPC分类号： C07D487/04 ,  C07D209/14 ,  C07D401/06 ,  C07D401/08 ,  C07D401/12 ,  C07D401/14 ,  C07D403/06 ,  C07D403/08 ,  C07D403/10 ,  C07D403/12 ,  C07D405/06 ,  C07D405/12 ,  C07D409/06 ,  C07D409/08 ,  C07D409/12 ,  C07D413/06 ,  C07D413/08 ,  C07D413/12 ,  C07D417/14 ,  C07D471/04 ,  C07D495/04 ,  C07D498/04 ,  C07D513/04

CPC分类号： C07D487/04 ,  C07D209/14 ,  C07D401/06 ,  C07D401/08 ,  C07D401/12 ,  C07D401/14 ,  C07D403/06 ,  C07D403/08 ,  C07D403/10 ,  C07D403/12 ,  C07D405/06 ,  C07D405/12 ,  C07D409/06 ,  C07D409/08 ,  C07D409/12 ,  C07D413/06 ,  C07D413/08 ,  C07D413/12 ,  C07D417/14 ,  C07D471/04 ,  C07D495/04 ,  C07D498/04 ,  C07D513/04

摘要： The present invention relates to a series of novel compounds, methods to prevent or treat viral infections in animals by using the novel compounds and to said novel compounds for use as a medicine, more preferably for use as a medicine to treat or prevent viral infections, particularly infections with RNA viruses, more particularly infections with viruses belonging to the family of the Flaviviridae, and yet more particularly infections with the Dengue virus. The present invention furthermore relates to pharmaceutical compositions or combination preparations of the novel compounds, to the compositions or preparations for use as a medicine, more preferably for the prevention or treatment of viral infections. The invention also relates to processes for preparation of the compounds.

公开(公告)号：US20240182426A1

公开(公告)日：2024-06-06

申请号：US18482475

申请日：2023-10-06

申请人： Epizyme, Inc.

发明人： Richard CHESWORTH ,  Lorna Helen Mitchell ,  Gideon Shapiro ,  Kerren Kalai Swinger

IPC分类号： C07D231/12 ,  A61K31/415 ,  A61K31/4155 ,  C07D401/04 ,  C07D403/04 ,  C07D403/08 ,  C07D405/04 ,  C07D405/08 ,  C07D405/12 ,  C07D493/10

CPC分类号： C07D231/12 ,  A61K31/415 ,  A61K31/4155 ,  C07D401/04 ,  C07D403/04 ,  C07D403/08 ,  C07D405/04 ,  C07D405/08 ,  C07D405/12 ,  C07D493/10

摘要： Described herein are compounds of Formula (I), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Compounds described herein are useful for inhibiting arginine methyltransferase activity. Methods of using the compounds for treating arginine methyltransferase-mediated disorders are also described.

公开(公告)号：US20240166608A1

公开(公告)日：2024-05-23

申请号：US18529689

申请日：2023-12-05

申请人： Insilico Medicine IP Limited

发明人： Xiao DING ,  Jinxin LIU ,  Feng REN ,  Jianfei WAN ,  Wei ZHU

IPC分类号： C07D231/56 ,  A61P35/00 ,  C07D209/44 ,  C07D215/14 ,  C07D401/04 ,  C07D403/08 ,  C07D471/04 ,  C07D487/04

CPC分类号： C07D231/56 ,  A61P35/00 ,  C07D209/44 ,  C07D215/14 ,  C07D401/04 ,  C07D403/08 ,  C07D471/04 ,  C07D487/04

摘要： The disclosure provides for compounds and methods for modulating or inhibiting TEAD. Further provided herein are pharmaceutical compositions comprising the TEAD inhibitors and methods of treatment using the TEAD inhibitors or the pharmaceutical compositions.

公开(公告)号：US11856849B2

公开(公告)日：2023-12-26

申请号：US16543685

申请日：2019-08-19

申请人： Merck Patent GmbH

发明人： Amir Hossain Parham ,  Irina Martynova ,  Anja Jatsch ,  Thomas Eberle ,  Jonas Kroeber ,  Christof Pflumm

IPC分类号： H01L51/54 ,  H10K85/60 ,  C07D405/14 ,  C07D403/10 ,  C07D403/14 ,  C07D409/14 ,  C07D491/048 ,  C07D403/08 ,  C07F7/08 ,  C07F5/02 ,  C07F15/00 ,  A61K41/00 ,  A61N5/06 ,  C07D495/14 ,  C09K11/02 ,  H10K50/11 ,  H10K85/30 ,  H10K101/10 ,  H10K101/00

CPC分类号： H10K85/6572 ,  A61K41/00 ,  A61N5/0616 ,  A61N5/0621 ,  C07D403/08 ,  C07D403/10 ,  C07D403/14 ,  C07D405/14 ,  C07D409/14 ,  C07D491/048 ,  C07D495/14 ,  C07F5/025 ,  C07F7/0814 ,  C07F15/0033 ,  C07F15/0086 ,  C09K11/025 ,  H10K85/654 ,  H10K85/657 ,  H10K85/6574 ,  H10K85/6576 ,  A61N2005/0653 ,  H10K50/11 ,  H10K85/342 ,  H10K85/631 ,  H10K2101/10 ,  H10K2101/90 ,  Y02E10/549

摘要： Compounds of formula (1) that have functional substituents in a specific spatial arrangement, and electronic devices that include a compound of formula (1), and to the preparation of compounds of formula (1).

公开(公告)号：US11773108B2

公开(公告)日：2023-10-03

申请号：US17751035

申请日：2022-05-23

申请人： TARO PHARMACEUTICALS INC.

发明人： Curtis Harwig ,  Jeremy D. Pettigrew ,  Jennifer Cross ,  Jeyaprakashnarayanan Seenisamy ,  Mahesh Narayan Keregadde ,  Karthikeyan Iyanar

IPC分类号： C07D493/10 ,  C07D231/54 ,  C07D401/08 ,  C07D403/08 ,  C07D417/08 ,  A61P29/00

CPC分类号： C07D493/10 ,  A61P29/00 ,  C07D231/54 ,  C07D401/08 ,  C07D403/08 ,  C07D417/08

摘要： Compounds of formula (1): wherein, R1, R2, R3, R4a, R4b and R5 are described herein, or a stereoisomer, enantiomer or tautomer thereof or mixtures thereof, or a pharmaceutically acceptable salt or solvate thereof, are described herein, as well as other compounds. These compounds are useful in treating inflammation and/or pain. Compositions comprising a compound of the invention are also disclosed, as are methods of using the compounds to treat inflammation and/or pain.

公开(公告)号：US20230295113A1

公开(公告)日：2023-09-21

申请号：US18183856

申请日：2023-03-14

申请人： ZOMAGEN BIOSCIENCES LTD

发明人： James COLLINS ,  Venkat BOLLU ,  Shendong YUAN ,  John NUSS

IPC分类号： C07D401/08 ,  C07D471/08 ,  C07D403/08 ,  C07D471/04

CPC分类号： C07D401/08 ,  C07D471/08 ,  C07D403/08 ,  C07D471/04

摘要： Described herein are NLRP3 modulators and methods of utilizing NLRP3 modulators in the treatment of diseases, disorders or conditions. Also described herein are pharmaceutical compositions containing such compounds.

公开(公告)号：US11731943B2

公开(公告)日：2023-08-22

申请号：US17177356

申请日：2021-02-17

申请人： Genentech, Inc.

发明人： James John Crawford ,  Mark Zak ,  Terry Kellar ,  Yun-Xing Cheng ,  Wei Li ,  F. Anthony Romero ,  Paul Gibbons ,  Guiling Zhao ,  Gregory Hamilton ,  Simon Charles Goodacre

IPC分类号： C07D231/40 ,  C07D401/04 ,  C07D401/14 ,  C07D403/08 ,  C07D405/04 ,  C07D405/12 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14

CPC分类号： C07D231/40 ,  C07D401/04 ,  C07D401/14 ,  C07D403/08 ,  C07D405/04 ,  C07D405/12 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14

摘要： Compounds of Formula (I):




and salts thereof, and methods of use as Janus kinase inhibitors are described herein.

公开(公告)号：US11731939B1

公开(公告)日：2023-08-22

申请号：US18118280

申请日：2023-03-07

申请人： KING FAISAL UNIVERSITY

发明人： Christophe Tratrat ,  Michelyne Haroun

IPC分类号： C07D209/40 ,  A61P31/10 ,  A61P31/06 ,  C07D403/08

CPC分类号： C07D209/40 ,  A61P31/06 ,  A61P31/10 ,  C07D403/08

摘要： The indole-based chalcone compounds are antibacterial agents. The emergence of drug-resistant bacteria calls for constant development of new antibacterial agents with the aim of generating medicaments that are potent against drug sensitive and resistant bacteria and are well tolerated. The present compounds are not only new, but have very valuable antimicrobial properties. These compounds showed a broad spectrum of activity against gram-positive and gram-negative bacteria, as well tuberculosis mycobacteria. They also showed potent activity against drug-resistant bacteria, such as MRSA and VRSA. The molecular target of these compounds was identified as DNA Gyrase B. Based on their pharmacological profiles, the present compounds may find important clinical applications for severe infectious diseases and tuberculosis.