公开(公告)号：US08273790B2

公开(公告)日：2012-09-25

申请号：US13370768

申请日：2012-02-10

申请人： Tiruvettipuram K. Thiruvengadam ,  Anantha Sudhakar ,  Ngiap Kie Lim ,  Daw-Iong Kwok ,  George G. Wu ,  Tao Wang ,  Mingsheng Huang ,  Michael D. Green

发明人： Tiruvettipuram K. Thiruvengadam ,  Anantha Sudhakar ,  Ngiap Kie Lim ,  Daw-Iong Kwok ,  George G. Wu ,  Tao Wang ,  Mingsheng Huang ,  Michael D. Green

IPC分类号： A61K31/335

CPC分类号： C07D493/10 ,  C07C235/28 ,  C07D295/185 ,  C07D307/92 ,  C07D317/72 ,  C07D405/06

摘要： This application discloses a novel process for the synthesis of himbacine analogs, as well as the compounds produced thereby. The synthesis proceeds by alternative routes including the cyclic ketal amide route, the chiral carbamate amide route, and the chiral carbamate ester route. The compounds produced thereby are useful as thrombin receptor antagonists. The chemistry disclosed herein is exemplified in the following synthesis sequence:

摘要翻译： 本申请公开了一种用于合成烟肼类似物的新方法，以及由此制备的化合物。 合成通过包括环状缩酮酰胺途径，手性氨基甲酸酯酰胺路线和手性氨基甲酸酯路线的替代途径进行。 由此制备的化合物可用作凝血酶受体拮抗剂。 本文公开的化学例如以下合成顺序：

公开(公告)号：US20120302745A1

公开(公告)日：2012-11-29

申请号：US13564966

申请日：2012-08-02

申请人： Tiruvettipuram K. Thiruvengadam ,  Anantha R. Sudhakar ,  Ngiap Kie Lim ,  Daw-Iong Kwok ,  George G. Wu ,  Tao Wang ,  Mingsheng Huang ,  Michael D. Green

发明人： Tiruvettipuram K. Thiruvengadam ,  Anantha R. Sudhakar ,  Ngiap Kie Lim ,  Daw-Iong Kwok ,  George G. Wu ,  Tao Wang ,  Mingsheng Huang ,  Michael D. Green

IPC分类号： C07C269/06 ,  C07D307/92 ,  C07D405/08 ,  C07D317/72 ,  C07D413/12

CPC分类号： C07D493/10 ,  C07C235/28 ,  C07D295/185 ,  C07D307/92 ,  C07D317/72 ,  C07D405/06

摘要： This application discloses a novel process for the synthesis of himbacine analogs, as well as the compounds produced thereby. The synthesis proceeds by alternative routes including the cyclic ketal amide route, the chiral carbamate amide route, and the chiral carbamate ester route. The compounds produced thereby are useful as thrombin receptor antagonists. The chemistry disclosed herein is exemplified in the following synthesis sequence:

摘要翻译： 本申请公开了一种用于合成烟肼类似物的新方法，以及由此制备的化合物。 合成通过包括环状缩酮酰胺途径，手性氨基甲酸酯酰胺路线和手性氨基甲酸酯路线的替代途径进行。 由此制备的化合物可用作凝血酶受体拮抗剂。 本文公开的化学例如以下合成顺序：

公开(公告)号：US20120142914A1

公开(公告)日：2012-06-07

申请号：US13370768

申请日：2012-02-10

申请人： Tiruvettipuram K. Thiruvengadam ,  Anantha R. Sudhakar ,  Ngiap Kie Lim ,  Daw-Iong Kwok ,  George G. Wu ,  Tao Wang ,  Mingsheng Huang ,  Michael D. Green

发明人： Tiruvettipuram K. Thiruvengadam ,  Anantha R. Sudhakar ,  Ngiap Kie Lim ,  Daw-Iong Kwok ,  George G. Wu ,  Tao Wang ,  Mingsheng Huang ,  Michael D. Green

IPC分类号： C07D413/12 ,  C07D307/92 ,  C07D405/08 ,  C07D317/72 ,  C07C269/06

CPC分类号： C07D493/10 ,  C07C235/28 ,  C07D295/185 ,  C07D307/92 ,  C07D317/72 ,  C07D405/06

摘要： This application discloses a novel process for the synthesis of himbacine analogs, as well as the compounds produced thereby. The synthesis proceeds by alternative routes including the cyclic ketal amide route, the chiral carbamate amide route, and the chiral carbamate ester route. The compounds produced thereby are useful as thrombin receptor antagonists. The chemistry disclosed herein is exemplified in the following synthesis sequence:

公开(公告)号：US20060217422A1

公开(公告)日：2006-09-28

申请号：US11330521

申请日：2006-01-12

申请人： Tiruvettipuram Thiruvengadam ,  Anantha Sudhakar ,  Ngiap Lim ,  Daw-long Kwok ,  George Wu ,  Tao Wang ,  Mingsheng Huang ,  Michael Green

发明人： Tiruvettipuram Thiruvengadam ,  Anantha Sudhakar ,  Ngiap Lim ,  Daw-long Kwok ,  George Wu ,  Tao Wang ,  Mingsheng Huang ,  Michael Green

IPC分类号： C07D405/02 ,  A61K31/4433

CPC分类号： C07D493/10 ,  C07C235/28 ,  C07D295/185 ,  C07D307/92 ,  C07D317/72 ,  C07D405/06

摘要： This application discloses a novel process for the synthesis of himbacine analogs, as well as the compounds produced thereby. The synthesis proceeds by alternative routes including the cyclic ketal amide route, the chiral carbamate amide route, and the chiral carbamate ester route. The compounds produced thereby are useful as thrombin receptor antagonists. The chemistry disclosed herein is exemplified in the following synthesis sequence:

摘要翻译： 本申请公开了一种用于合成烟肼类似物的新方法，以及由此制备的化合物。 合成通过包括环状缩酮酰胺途径，手性氨基甲酸酯酰胺路线和手性氨基甲酸酯路线的替代途径进行。 由此制备的化合物可用作凝血酶受体拮抗剂。 本文公开的化学例如以下合成顺序：

公开(公告)号：US20130064963A1

公开(公告)日：2013-03-14

申请号：US13605698

申请日：2012-09-06

申请人： Nicholas J. Leisure ,  Carla C. Jackson ,  Mingsheng Huang ,  Theodore B. Moore ,  Fredrick A. Steward

发明人： Nicholas J. Leisure ,  Carla C. Jackson ,  Mingsheng Huang ,  Theodore B. Moore ,  Fredrick A. Steward

IPC分类号： A23L1/304 ,  A23K1/175

CPC分类号： A23K20/24 ,  A23L29/212 ,  A23L33/16

摘要： A micronutrient supplement which is made by reacting a metal oxide, or metal hydroxide, or metal carbonate of an essential mineral and an acid and/or a metal salt of an essential mineral containing a digestible binder to form a slurry of micronutrient crystals and a digestible binder and forming agglomerated particles of the micronutrient crystals from the slurry. The agglomerated particles provide a non-dusting, free-flowing micronutrient supplement that can be produced with desired particle sizes and densities so as to be easily mixed with a variety of feed mixtures. The digestible binder in the agglomerated particles reduces the opportunity for interactions between the micronutrient crystals and other ingredients that can be present in complex feed mixtures while allowing release of the micronutrients in an animal's digestive system.

摘要翻译： 一种微量营养素补充剂，其通过金属氧化物或金属氢氧化物或必需矿物质的金属碳酸盐和含有可消化粘合剂的必需矿物的酸和/或金属盐反应形成微量营养素晶体和可消化的 粘合剂和从浆料形成微量营养素晶体的团聚颗粒。 附聚颗粒提供无尘，自由流动的微量营养素补充剂，其可以用所需的粒度和密度生产，以便容易地与各种饲料混合物混合。 附聚颗粒中的可消化粘合剂降低了微量营养物晶体与可在复合饲料混合物中存在的其它成分之间相互作用的机会，同时允许在动物消化系统中释放微量营养素。

公开(公告)号：US08802180B2

公开(公告)日：2014-08-12

申请号：US13605698

申请日：2012-09-06

申请人： Nicholas J. Leisure ,  Carla C. Jackson ,  Mingsheng Huang ,  Theodore B. Moore ,  Fredrick A. Steward

发明人： Nicholas J. Leisure ,  Carla C. Jackson ,  Mingsheng Huang ,  Theodore B. Moore ,  Fredrick A. Steward

IPC分类号： A23L1/304

CPC分类号： A23K20/24 ,  A23L29/212 ,  A23L33/16

摘要： A micronutrient supplement which is made by reacting a metal oxide, or metal hydroxide, or metal carbonate of an essential mineral and an acid and/or a metal salt of an essential mineral containing a digestible binder to form a slurry of micronutrient crystals and a digestible binder and forming agglomerated particles of the micronutrient crystals from the slurry. The agglomerated particles provide a non-dusting, free-flowing micronutrient supplement that can be produced with desired particle sizes and densities so as to be easily mixed with a variety of feed mixtures. The digestible binder in the agglomerated particles reduces the opportunity for interactions between the micronutrient crystals and other ingredients that can be present in complex feed mixtures while allowing release of the micronutrients in an animal's digestive system.

摘要翻译： 一种微量营养素补充剂，其通过金属氧化物或金属氢氧化物或必需矿物质的金属碳酸盐和含有可消化粘合剂的必需矿物的酸和/或金属盐反应形成微量营养素晶体和可消化的 粘合剂和从浆料形成微量营养素晶体的团聚颗粒。 附聚颗粒提供无尘，自由流动的微量营养素补充剂，其可以用所需的粒度和密度生产，以便容易地与各种饲料混合物混合。 附聚颗粒中的可消化粘合剂降低了微量营养物晶体与可在复合饲料混合物中存在的其它成分之间相互作用的机会，同时允许在动物消化系统中释放微量营养素。