专利检索 ap:("Gosse Adema" OR "Linde Meyaard" OR "Daniel Gorman" OR "Terrill McClanahan" OR "Sandra Zurawski" OR "Gerard Zurawski" OR "Lewis Lanier" OR "Joseph Phillips") AND inv:"Terrill McClanahan" 第 2 页

11.

发明授权
Canine RANKL and methods for preparing and using the same 失效
标题翻译：犬RANKL及其制备及使用方法

公开(公告)号：US08030450B2

公开(公告)日：2011-10-04

申请号：US12266359

申请日：2008-11-06

申请人： Jeanine D. Mattson , Terrill McClanahan

发明人： Jeanine D. Mattson , Terrill McClanahan

IPC分类号： C07K14/51 , A61K38/18 , A61K39/00

CPC分类号： C07K14/70575 , A61K38/00 , A61K39/00 , C07K16/2875

摘要： The present invention provides isolated nucleic acid molecules that encode a substantial part of canine RANKL polypeptide, including the extracellular domains of that polypeptide, the polypeptide and fragments thereof. Vectors and host cells encoding and expressing canine RANKL polypeptide are provided, as well as antibodies that bind to RANKL and that inhibit RANKL activity. Also provided are methods of treating an animal to inhibit or treat the loss of bone minerals.

摘要翻译： 本发明提供编码大部分犬RANKL多肽的分离的核酸分子，包括该多肽的细胞外结构域，多肽及其片段。提供编码和表达犬RANKL多肽的载体和宿主细胞，以及结合RANKL并抑制RANKL活性的抗体。还提供了治疗动物以抑制或治疗骨矿物质损失的方法。

12.

发明申请
CANINE RANKL AND METHODS FOR PREPARING AND USING THE SAME 失效
标题翻译： CANINE RANKL及其制备和使用方法

公开(公告)号：US20090148456A1

公开(公告)日：2009-06-11

申请号：US12266359

申请日：2008-11-06

申请人： Jeanine D. Mattson , Terrill McClanahan

发明人： Jeanine D. Mattson , Terrill McClanahan

IPC分类号： A61K39/395 , C07K7/00 , C07K14/435 , C12N5/00 , A61K39/00 , C07K16/00

CPC分类号： C07K14/70575 , A61K38/00 , A61K39/00 , C07K16/2875

摘要： The present invention provides isolated nucleic acid molecules that encode a substantial part of canine RANKL polypeptide, including the extracellular domains of that polypeptide, the polypeptide and fragments thereof. Vectors and host cells encoding and expressing canine RANKL polypeptide are provided, as well as antibodies that bind to RANKL and that inhibit RANKL activity. Also provided are methods of treating an animal to inhibit or treat the loss of bone minerals.

摘要翻译： 本发明提供编码大部分犬RANKL多肽的分离的核酸分子，包括该多肽的细胞外结构域，多肽及其片段。提供编码和表达犬RANKL多肽的载体和宿主细胞，以及结合RANKL并抑制RANKL活性的抗体。还提供了治疗动物以抑制或治疗骨矿物质损失的方法。

13.

发明申请
Use of cytokine expression to predict skin inflammation; methods of treatment 审中-公开
标题翻译：使用细胞因子表达预测皮肤炎症; 治疗方法

公开(公告)号：US20050287593A1

公开(公告)日：2005-12-29

申请号：US11218446

申请日：2005-09-02

申请人： Robert Kastelein , Terrill McClanahan , Erin Murphy , Jason Chan

发明人： Robert Kastelein , Terrill McClanahan , Erin Murphy , Jason Chan

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6881 , A61K31/713 , A61K39/3955 , C12Q1/6883 , C12Q2600/106 , C12Q2600/158

摘要： Provided are methods for diagnosing the propensity of a subject to develop skin inflammation, in particular, psoriasis. Also provided are methods of treatment with antagonists of IL-17, IL-19, and/or IL-23.

摘要翻译： 提供了用于诊断受试者发展皮肤炎症，特别是牛皮癣的倾向的方法。还提供了用IL-17，IL-19和/或IL-23的拮抗剂治疗的方法。