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11.发明申请Phosphorylated and Branched Dihydroxy-Pentane-Dione (DPD) Analogs as Quorum Sensing Inhibitors in Bacteria 有权磷酸化和支化的二羟基 - 戊烷二酮（DPD）类似物作为细菌中的法定感觉抑制剂公开(公告)号：US20120294900A1
公开(公告)日：2012-11-22
申请号：US13430000
申请日：2012-03-26
IPC分类号： A01N35/02 , C07C49/337 , C07C49/82 , C07C205/45 , C07D307/46 , C07C69/28 , C07C69/16 , C07C235/80 , C07F9/09 , A61K31/121 , A01N35/00 , A01N35/04 , A61K31/12 , A01N43/08 , A61K31/341 , A01N37/12 , A01N57/12 , A61K31/661 , A01P1/00 , A61P31/04 , A61K9/00 , C07C49/17
CPC分类号： C07C317/24 , A01N35/02 , A01N35/04 , A01N37/12 , A01N43/08 , A01N57/12 , C07C49/17 , C07C49/337 , C07C49/82 , C07C69/16 , C07C69/28 , C07C205/45 , C07C235/80 , C07D241/42 , C07D307/46 , C07D405/04 , C07F9/091 , C07F9/3808
摘要： Provided are compositions and methods for modulating quorum sensing in microbes. The compounds are AI-2 analogs and as such have structures similar to 4,5-dihydroxy-2,3-pentanedione that can act as agonists/antagonists of quorum sensing. The compounds are useful for modulating quorum sensing in bacteria and can be used in methods for prophylaxis or therapy of bacterial infections and for reduction of biofilms.
摘要翻译： 提供了调节微生物群体感应的组合物和方法。 化合物是AI-2类似物，因此具有类似于4,5-二羟基-2,3-戊二酮的结构，其可以作为群体感应的激动剂/拮抗剂。 该化合物可用于调节细菌中的群体感应，并可用于预防或治疗细菌感染和减少生物膜的方法。
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12.发明授权公开(公告)号：US07157562B1
公开(公告)日：2007-01-02
申请号：US10414555
申请日：2003-04-14
CPC分类号： C07K16/00 , Y10S530/866 , Y10S530/867
摘要： A process for producing recombinant anti-botulinum toxin antibody comprising the steps of fermenting recombinant E. Coli cells in broth, concentrating the cells by removing the broth, crushing the concentrated cells, separating a permeate derived from the crushed cells from cell debris, purifying a recombinant antibotulinum antibody (Fab) from said permeate, and separating said Fab from impurities by diafiltration.
摘要翻译： 一种生产重组抗肉毒杆菌毒素抗体的方法，包括以下步骤：在肉汤中发酵重组大肠杆菌细胞，通过去除培养液浓缩细胞，粉碎浓缩细胞，从细胞碎片中分离源自破碎细胞的渗透物，纯化 来自所述渗透物的重组抗微生物素抗体（Fab），并通过渗滤将所述Fab与杂质分离。
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