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20 条记录 (耗时 0.031 秒)

    Particulate drug-containing products and method of manufacture
    13.
    发明授权
    Particulate drug-containing products and method of manufacture 有权

    公开(公告)号：US07125566B2

    公开(公告)日：2006-10-24

    申请号：US10717429

    申请日：2003-11-19

    申请人： Jeffrey B. Etter

    发明人： Jeffrey B. Etter

    IPC分类号： A61K9/14

    CPC分类号： A61K9/0075 ,  A61K9/14 ,  A61K9/1617 ,  A61K9/1647 ,  A61K9/1694 ,  A61K38/00 ,  A61K48/00

    摘要： Provided is a compressed anti-solvent technique for manufacture of drug-containing powders for pulmonary delivery. The drug is processed in a cosolvent system including two or more mutually soluble organic solvents. Also provided are powders manufacturable by the manufacture method, including powders of substantially pure drug and powders including a biocompatible polymer for pulmonary sustained drug release applications. Also provided are packaged products including drug-containing powder in a container that is receivable by and operable with a dry powder inhaler to produce an aerosol including dispersed drug-containing particles when the inhaler is actuated.

    Particulate insulin-containing products and method of manufacture
    14.
    发明授权
    Particulate insulin-containing products and method of manufacture 有权
    颗粒胰岛素产品及其制造方法

    公开(公告)号：US06761909B1

    公开(公告)日：2004-07-13

    申请号：US09469733

    申请日：1999-12-21

    申请人： Jeffrey B. Etter

    发明人： Jeffrey B. Etter

    IPC分类号： A61K914

    CPC分类号： A61K9/1617 ,  A61K9/14 ,  A61K9/1647 ,  A61K9/1694 ,  A61K38/00 ,  A61K48/00

    摘要： Provided is a compressed anti-solvent technique for manufacture of insulin-containing powders for pulmonary delivery. The insulin is processed in a cosolvent system including two or more mutually soluble organic solvents. Also provided are powders manufacturable by the manufacture method, including powders of substantially pure insulin and powders including a biocompatible polymer for pulmonary sustained insulin release applications. Also provided are packaged products including insulin-containing powder in a container that is receivable by and operable with a dry powder inhaler to produce an aerosol including dispersed insulin-containing particles when the inhaler is actuated.

    摘要翻译： 提供了用于制造用于肺部输送的含胰岛素的粉末的压缩的反溶剂技术。 胰岛素在包含两种或多种相互溶解的有机溶剂的助溶剂体系中进行处理。 还提供了可通过制造方法制造的粉末，其包括基本上纯的胰岛素粉末和包括用于肺持续胰岛素释放应用的生物相容性聚合物的粉末。 还提供包括在容器中的包含含胰岛素的粉末的包装产品，所述容器能够通过干粉吸入器接收并且可操作，以在吸入器致动时产生包含分散的含胰岛素颗粒的气溶胶。

    COLON-TARGETED ORAL FORMULATIONS OF CYTIDINE ANALOGS
    16.
    发明申请
    COLON-TARGETED ORAL FORMULATIONS OF CYTIDINE ANALOGS 审中-公开
    CYTIDINE ANALOGS的定向口服制剂

    公开(公告)号：US20080057086A1

    公开(公告)日：2008-03-06

    申请号：US11849958

    申请日：2007-09-04

    申请人： Jeffrey B. Etter

    发明人： Jeffrey B. Etter

    IPC分类号： A61K9/00 ,  A61K31/7068 ,  A61P43/00

    CPC分类号： A61K31/7068 ,  A61K9/2846 ,  A61K9/2886 ,  A61K9/4891

    摘要： The present invention provides an oral formulation of a cytidine analog, including, 5-azacytidine, for delivery to the lower gastrointestinal tract, including, the large intestine; methods to treat diseases associated with abnormal cell proliferation by treatment with the oral formulations of the present invention; and methods to increase the bioavailability of a cytidine analog upon administration to a patient by providing an oral formulation of the present invention.

    摘要翻译： 本发明提供了包含5-氮杂胞苷的胞苷类似物的口服制剂，用于递送至下胃肠道，包括大肠; 用本发明的口服制剂治疗与异常细胞增殖相关的疾病的方法; 以及通过提供本发明的口服制剂在给予患者时增加胞苷类似物的生物利用度的方法。

    Particulate drug-containing products and method of manufacture
    17.
    发明授权
    Particulate drug-containing products and method of manufacture 有权
    颗粒含药产品及其制造方法

    公开(公告)号：US06669960B2

    公开(公告)日：2003-12-30

    申请号：US09740573

    申请日：2000-12-18

    申请人： Jeffrey B. Etter

    发明人： Jeffrey B. Etter

    IPC分类号： A61K914

    CPC分类号： A61K9/0075 ,  A61K9/14 ,  A61K9/1617 ,  A61K9/1647 ,  A61K9/1694 ,  A61K38/00 ,  A61K48/00

    摘要： Provided is a compressed anti-solvent technique for manufacture of drug-containing powders for pulmonary delivery. The drug is processed in a cosolvent system including two or more mutually soluble organic solvents. Also provided are powders manufacturable by the manufacture method, including powders of substantially pure drug and powders including a biocompatible polymer for pulmonary sustained drug release applications. Also provided are packaged products including drug-containing powder in a container that is receivable by and operable with a dry powder inhaler to produce an aerosol including dispersed drug-containing particles when the inhaler is actuated.

    摘要翻译： 提供了用于制造用于肺部递送的含药粉末的压缩反溶剂技术。 该药物在包含两种或多种相互溶解的有机溶剂的助溶剂体系中进行处理。 还提供了可通过制造方法制造的粉末，包括基本上纯的药物和粉末的粉末，其包括用于肺持续药物释放应用的生物相容性聚合物。 还提供了包含药物的粉末在包装容器中的包装产品，该容器能够通过干粉吸入器接收和操作，以在吸入器致动时产生包含分散的含药颗粒的气溶胶。