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公开(公告)号：US20090232835A1
公开(公告)日：2009-09-17
申请号：US12291344
申请日：2008-11-06
CPC分类号： A61K9/0024 , A61K31/505 , A61K31/513 , A61K35/545 , A61K38/18 , A61K38/193 , A61K38/2046 , A61K47/10 , A61K47/36 , A61K47/38 , A61K2300/00
摘要： A hematopoietic growth factor delivery composition includes a hematopoietic growth factor, a liquid vehicle, a first biocompatible polymer and a second biocompatible polymer. The composition exhibits reverse-thermal viscosity behavior, due to interaction between the first biocompatible polymer and the liquid vehicle. The second biocompatible polymer helps to protect the first biocompatible polymer from being dissolved in vivo following administration to a host.
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公开(公告)号：US06875441B2
公开(公告)日：2005-04-05
申请号：US09893339
申请日：2001-06-26
IPC分类号： A61K9/00 , A61K9/52 , A61K38/18 , A61K38/19 , A61K38/20 , A61K47/10 , A61K47/36 , A61K47/38 , C12N5/02 , A61K38/00
CPC分类号： A61K9/0024 , A61K31/505 , A61K31/513 , A61K35/545 , A61K38/18 , A61K38/193 , A61K38/2046 , A61K47/10 , A61K47/36 , A61K47/38 , A61K2300/00
摘要： A hematopoietic growth factor delivery composition includes a hematopoietic growth factor, a liquid vehicle, a first biocompatible polymer and a second biocompatible polymer. The composition exhibits reverse-thermal viscosity behavior, due to interaction between the first biocompatible polymer and the liquid vehicle. The second biocompatible polymer helps to protect the first biocompatible polymer from being dissolved in vivo following administration to a host.
摘要翻译： 造血生长因子递送组合物包括造血生长因子，液体载体，第一生物相容性聚合物和第二生物相容性聚合物。 由于第一生物相容性聚合物和液体载体之间的相互作用，该组合物显示出反向热粘性行为。 第二生物相容性聚合物有助于保护第一生物相容性聚合物在施用于宿主后在体内溶解。
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公开(公告)号：US06685917B2
公开(公告)日：2004-02-03
申请号：US09993383
申请日：2001-11-21
IPC分类号： A61K31195
CPC分类号： A61K31/195 , A61K9/0014 , A61K9/006 , A61K9/06 , A61K31/198 , A61K47/10 , A61K47/34
摘要： This present invention provides a therapeutic composition for use in the treatment of mucositis and a method for using such a therapeutic composition. The therapeutic composition includes a pharmaceutical substance effective for treating mucositis formulated with a biocompatible polymer, such as a biocompatible reverse-thermal gelation polymer.
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公开(公告)号：US06649189B2
公开(公告)日：2003-11-18
申请号：US09893372
申请日：2001-06-26
IPC分类号： A61K914
CPC分类号： A61K9/0024 , A61K31/505 , A61K31/513 , A61K35/545 , A61K38/18 , A61K38/193 , A61K38/2046 , A61K47/10 , A61K47/36 , A61K47/38 , A61K2300/00
摘要： A hematopoietic growth factor delivery composition includes a hematopoietic growth factor, a liquid vehicle, a first biocompatible polymer and a second biocompatible polymer. The composition exhibits reverse-thermal viscosity behavior, due to interaction between the first biocompatible polymer and the liquid vehicle. The second biocompatible polymer helps to protect the first biocompatible polymer from being dissolved in vivo following administration to a host.
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公开(公告)号：US5468606A
公开(公告)日：1995-11-21
申请号：US923304
申请日：1992-07-31
IPC分类号： G01N21/21 , G01N21/45 , G01N21/47 , G01N21/77 , G01N33/543 , G01N33/551 , G01N33/552 , G01N33/545
CPC分类号： B82Y30/00 , B82Y15/00 , G01N21/211 , G01N21/4738 , G01N21/77 , G01N33/54366 , G01N33/54373 , G01N33/551 , G01N33/552 , G01N21/45 , Y10S435/808 , Y10S436/805
摘要： Device for detecting the presence or amount of an analyte of interest, having a substrate possessing an optically active surface which exhibits a first color in response to light impinging thereon, and exhibits a second color comprising a combination of wavelengths of light different from the first color or comprising an intensity of at least one wavelength of light different from the first color, in response to the light when the analyte is present on the surface in any amount selected from 0.1 nM, 0.1 ng/ml, 50 fg, and 2.times.10.sup.3 organisms comprising the analyte.
摘要翻译： 用于检测感兴趣的分析物的存在或量的装置，具有具有光学活性表面的基底，所述基底表现出响应于其上的光的第一颜色，并且显示第二颜色，其包括与第一颜色不同的光的波长的组合 或者当所述分析物以选自0.1nM，0.1ng / ml，50fg和2x103生物体的任何量存在于所述表面上时，响应于所述光而包含至少一种不同于所述第一颜色的波长的光的强度，所述生物体包含 分析物。
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6.发明授权公开(公告)号：US09393255B2
公开(公告)日：2016-07-19
申请号：US13363008
申请日：2012-01-31
申请人： Anthony Tutino , Mei Lai , Jeffrey B. Etter
发明人： Anthony Tutino , Mei Lai , Jeffrey B. Etter
IPC分类号： A61K31/706 , A61P35/00 , A61P35/02 , A61K9/00
CPC分类号： A61K31/706 , A61K9/0019
摘要： The present disclosure provides pharmaceutical compositions comprising cytidine analogs for parenteral administration. Also provided are methods of preparing the compositions and methods of treating diseases and disorders using the compositions provided herein.
摘要翻译： 本公开提供了包含用于肠胃外给药的胞苷类似物的药物组合物。 还提供了使用本文提供的组合物制备治疗疾病和病症的组合物和方法的方法。
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7.发明授权Compositions of allosteric hemoglobin modifiers and methods of making the same 有权变构血红蛋白修饰剂的组成及其制备方法公开(公告)号：US07847120B2
公开(公告)日：2010-12-07
申请号：US11112389
申请日：2005-04-22
申请人： Al Quick , Antonio M. Santos , Alexandre J G G Carvalho , Douglas G. Johnson , Jeffrey B. Etter , Christopher Murray
发明人： Al Quick , Antonio M. Santos , Alexandre J G G Carvalho , Douglas G. Johnson , Jeffrey B. Etter , Christopher Murray
IPC分类号： C07C229/00 , C07C65/03
CPC分类号： A61K31/195
摘要： The present invention provides novel compositions of allosteric hemoglobin modifiers which are substantially free of impurities, specifically polymeric impurities. In one embodiment, the novel compositions contain an allosteric hemoglobin modifier compound and less than 100 ppm of the polymeric impurities generated during the preparation of this compound. Included in the present invention are novel methods for preparing allosteric hemoglobin modifiers that are substantially free of polymeric impurities. Also included in the present invention are improved methods for the purification of the product formed by the method of this invention. The novel methods of purification comprise extracting the crude composition with a water immiscible or partially immiscible solvent such as methylisobutyl ketone (MIBK) to lower amounts of impurities, specifically polymeric impurities. Also included are methods to reduce impurities by recrystallization of the crude synthesized product, followed by filtration of the recrystallized product. The present invention also includes the products made by the processes of the invention and methods for analyzing compositions comprised of these products.
摘要翻译： 本发明提供基本上不含杂质，特别是聚合物杂质的变构血红蛋白改性剂的新型组合物。 在一个实施方案中，新型组合物含有变构血红蛋白改性剂化合物，并且在制备该化合物期间产生小于100ppm的聚合物杂质。 本发明包括制备基本上不含聚合物杂质的变构型血红蛋白改性剂的新方法。 本发明还包括用于纯化通过本发明方法形成的产品的改进方法。 新颖的纯化方法包括用与水不混溶或部分不混溶的溶剂如甲基异丁基酮（MIBK）提取粗组合物以降低杂质量，特别是聚合物杂质。 还包括通过粗合成产物的重结晶减少杂质的方法，然后过滤重结晶产物。 本发明还包括通过本发明的方法制备的产品和用于分析由这些产品组成的组合物的方法。
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8.发明授权公开(公告)号：US07153651B1
公开(公告)日：2006-12-26
申请号：US08950963
申请日：1997-10-15
申请人： Joel A. Drewes , Gregory R. Bogart , Jeffrey B. Etter , Jeffrey W. Steaffens , Rachel M. Ostroff , Mark Crosby
发明人： Joel A. Drewes , Gregory R. Bogart , Jeffrey B. Etter , Jeffrey W. Steaffens , Rachel M. Ostroff , Mark Crosby
CPC分类号： G01N33/54373 , G01N21/7703
摘要： An optical assay device for the detection of an analyte of interest in a sample comprising a support containing channels, an optically functional layer positioned on the support such that the optically functional layer and the support allow for laminar flow of the sample through layers of the device, an attachment layer positioned on the optically functional layer, and an analyte specific receptive layer positioned on the attachment layer.
摘要翻译： 一种用于检测样品中感兴趣分析物的光学测定装置，包括含有通道的载体，位于载体上的光学功能层，使得光学功能层和载体允许样品层流流过该装置的层 ，位于光学功能层上的附着层和位于附着层上的分析物特异性接收层。
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公开(公告)号：US06933112B1
公开(公告)日：2005-08-23
申请号：US09675518
申请日：2000-09-29
申请人： Joel A. Drewes , Gregory R. Bogart , Jeffrey B. Etter , Jeffrey W. Steaffens , Rachel M. Ostroff , Mark Crosby
发明人： Joel A. Drewes , Gregory R. Bogart , Jeffrey B. Etter , Jeffrey W. Steaffens , Rachel M. Ostroff , Mark Crosby
IPC分类号： G01N31/22 , C12M1/00 , C12Q1/68 , G01N21/27 , G01N21/77 , G01N33/543 , G01N33/553 , G01N15/06
CPC分类号： G01N33/54373 , G01N21/7703
摘要： An optical assay device for the detection of an analyte of interest in a sample comprising a support containing channels, an optically functional layer positioned on the support such that the optically functional layer and the support allow for laminar flow of the sample through layers of the device, an attachment layer positioned on the optically functional layer, and an analyte specific receptive layer positioned on the attachment layer.
摘要翻译： 一种用于检测样品中感兴趣分析物的光学测定装置，包括含有通道的载体，位于载体上的光学功能层，使得光学功能层和载体允许样品层流流过该装置的层 ，位于光学功能层上的附着层和位于附着层上的分析物特异性接收层。
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公开(公告)号：US08372798B2
公开(公告)日：2013-02-12
申请号：US10271832
申请日：2002-10-16
IPC分类号： A61K49/14
CPC分类号： A61K49/14 , A61K9/0019 , A61K9/146 , A61K39/39591 , A61K47/10 , A61K47/26
摘要： Provided is a pharmaceutical composition involving a concentrated mixture of a precipitated protein and a liquid medium and a method for manufacturing the concentrated mixture. The concentrated mixture is manufacturable by precipitation of a protein with a biocompatible polymer precipitating agent, followed by removal of sufficient liquid to concentrate the resulting mixture to the desired degree. The precipitated protein can be stored for a significant time in the concentrated mixture, such as intermediate between processing stages during manufacture operations.
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