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公开(公告)号：US11524995B2
公开(公告)日：2022-12-13
申请号：US16895471
申请日：2020-06-08
Applicant: H. Lundbeck A/S
Inventor： Pekka Kallunki , Karina Fog , Louise Buur Vesterager , Ann-Louise Bergström , Florence Sotty , David Satijn , Edward van den Brink , Paul Parren , Rik Rademaker , Tom Vink , Ibrahim John Malik , Liliana Christina Pereira Montezinho , Jeffrey B. Stavenhagen
Abstract: The invention relates to novel monoclonal anti-alpha-synuclein antibodies. The antibodies can be used for treating a synucleinopathy such as Parkinson's disease (including idiopathic and inherited forms of Parkinson's disease), Diffuse Lewy Body Disease (DLBD), Lewy body variant of Alzheimer's disease (LBV), Combined Alzheimer's and Parkinson disease, pure autonomic failure and multiple system atrophy.
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公开(公告)号：US10889650B2
公开(公告)日：2021-01-12
申请号：US16521279
申请日：2019-07-24
Applicant: H. Lundbeck A/S
Inventor： Lars Christian Biilmann Rønn , Ibrahim John Malik , Jeffrey B. Stavenhagen , Søren Christensen , Jan Egebjerg , Arnout Gerritsen , Edward van den Brink , Paul Parren , Rob de Jong
Abstract: The present invention relates to monoclonal anti-Sortilin antibodies which have been found useful in correcting a deficient level of progranulin (PGRN). In particular, these antibodies can be used in the treatment of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS).
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公开(公告)号：US10647763B2
公开(公告)日：2020-05-12
申请号：US16443187
申请日：2019-06-17
Applicant: H. Lundbeck A/S
Inventor： Pekka Kallunki , Karina Fog , Louise Buur Vesterager , Ann-Louise Bergstrôm , Florence Sotty , David Satijn , Edward Van Den Brink , Paul Parren , Rik Rademaker , Tom Vink , Ibrahim John Malik , Liliana Christina Pereira Montezinho
Abstract: The invention relates to novel monoclonal anti-alpha-synuclein antibodies. The antibodies can be used for treating a synucleinopathy such as Parkinson's disease (including idiopathic and inherited forms of Parkinson's disease), Diffuse Lewy Body Disease (DLBD), Lewy body variant of Alzheimer's disease (LBV), Combined Alzheimer's and Parkinson disease, pure autonomic failure and multiple system atrophy.
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公开(公告)号：US10364285B2
公开(公告)日：2019-07-30
申请号：US15812363
申请日：2017-11-14
Applicant: H. Lundbeck A/S
Inventor： Pekka Kallunki , Karina Fog , Louise Buur Vesterager , Ann-Louise Bergstrôm , Florence Sotty , David Satijn , Edward van den Brink , Paul Parren , Rik Rademaker , Tom Vink , Ibrahim John Malik , Liliana Christina Pereira Montezinho
IPC: C07K16/18 , A61K39/395 , A61K51/00 , G01N33/68 , A61K39/00
Abstract: The invention relates to novel monoclonal anti-alpha-synuclein antibodies. The antibodies can be used for treating a synucleinopathy such as Parkinson's disease (including idiopathic and inherited forms of Parkinson's disease), Diffuse Lewy Body Disease (DLBD), Lewy body variant of Alzheimer's disease (LBV), Combined Alzheimer's and Parkinson disease, pure autonomic failure and multiple system atrophy.
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公开(公告)号：US11548950B2
公开(公告)日：2023-01-10
申请号：US17097457
申请日：2020-11-13
Applicant: H. Lundbeck A/S
Inventor： Lars Christian Biilmann Rønn , Ibrahim John Malik , Jeffrey B. Stavenhagen , Søren Christensen , Jan Egebjerg , Arnout Gerritsen , Edward van den Brink , Paul Parren , Rob de Jong
Abstract: The present invention relates to monoclonal anti-Sortilin antibodies which have been found useful correcting a deficient level progranulin (PGRN). In particular, these antibodies can be used in the treatment of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS).
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Patent Agency Ranking
公开(公告)号：US20210292414A1
公开(公告)日：2021-09-23
申请号：US17118934
申请日：2020-12-11
Applicant: H. Lundbeck A/S
Inventor： Lars Christian Biilmann Rønn , Ibrahim John Malik , Jeffrey B. Stavenhagen , Søren Christensen , Jan Egebjerg , Tina Stummann , Arnout Gerritsen , Edward van den Brink , Paul Parren , Esben Trabjerg , Kasper Dyrberg Rand
IPC: C07K16/28
Abstract: The present invention relates to monoclonal anti-Sortilin antibodies which have been found useful in correcting a deficient level of progranulin (PGRN). In particular, these antibodies can be used in the treatment of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) and other neurodegenerative disorders such as Alzheimers disease (AD).
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公开(公告)号：US20200309796A1
公开(公告)日：2020-10-01
申请号：US16955984
申请日：2018-12-19
Applicant: H. Lundbeck A/S
Inventor： Ibrahim John Malik , Pekka Kallunki , Karina Fog
IPC: G01N33/68 , G01N33/542 , G01N33/58 , C07K16/18
Abstract: A method of detecting alpha-synuclein in a sample of a subject comprising the steps of a) Obtaining a sample from a subject,5 b) Applying the sample on a luminescence assay, and c) Optionally, comparing the results with a control
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公开(公告)号：US20180127492A1
公开(公告)日：2018-05-10
申请号：US15812303
申请日：2017-11-14
Applicant: H. Lundbeck A/S
Inventor： Pekka Kallunki , Karina Fog , Louise Buur Vesterager , Ann-Louise Bergstrôm , Florence Sotty , David Satijn , Edward van den Brink , Paul Parren , Rik Rademaker , Tom Vink , Ibrahim John Malik , Liliana Christina Pereira Montezinho
CPC classification number: C07K16/18 , A61K39/3955 , A61K51/00 , A61K2039/505 , C07K2317/21 , C07K2317/33 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , G01N33/6896 , G01N2800/2835
Abstract: The invention relates to novel monoclonal anti-alpha-synuclein antibodies. The antibodies can be used for treating a synucleinopathy such as Parkinson's disease (including idiopathic and inherited forms of Parkinson's disease), Diffuse Lewy Body Disease (DLBD), Lewy body variant of Alzheimer's disease (LBV), Combined Alzheimer's and Parkinson disease, pure autonomic failure and multiple system atrophy.
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公开(公告)号：US20180127491A1
公开(公告)日：2018-05-10
申请号：US15812251
申请日：2017-11-14
Applicant: H. Lundbeck A/S
Inventor： Pekka Kallunki , Karina Fog , Louise Buur Vesterager , Ann-Louise Bergstrôm , Florence Sotty , David Satijn , Edward van den Brink , Paul Parren , Rik Rademaker , Tom Vink , Ibrahim John Malik , Liliana Christina Pereira Montezinho
CPC classification number: C07K16/18 , A61K39/3955 , A61K51/00 , A61K2039/505 , C07K2317/21 , C07K2317/33 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , G01N33/6896 , G01N2800/2835
Abstract: The invention relates to novel monoclonal anti-alpha-synuclein antibodies. The antibodies can be used for treating a synucleinopathy such as Parkinson's disease (including idiopathic and inherited forms of Parkinson's disease), Diffuse Lewy Body Disease (DLBD), Lewy body variant of Alzheimer's disease (LBV), Combined Alzheimer's and Parkinson disease, pure autonomic failure and multiple system atrophy.
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公开(公告)号：US20170015739A1
公开(公告)日：2017-01-19
申请号：US15207859
申请日：2016-07-12
Applicant: H. Lundbeck A/S
Inventor： Pekka Kallunki , Karina Fog , Louise Buur Vesterager , Ann-Louise Bergstrôm , Florence Sotty , David Satijn , Edward van den Brink , Paul Parren , Rik Rademaker , Tom Vink , Ibrahim John Malik , Liliana Christina Pereira Montezinho
Abstract: The invention relates to novel monoclonal anti-alpha-synuclein antibodies. The antibodies can be used for treating a synucleinopathy such as Parkinson's disease (including idiopathic and inherited forms of Parkinson's disease), Diffuse Lewy Body Disease (DLBD), Lewy body variant of Alzheimer's disease (LBV), Combined Alzheimer's and Parkinson disease, pure autonomic failure and multiple system atrophy.
Abstract translation: 本发明涉及新的单克隆抗α-突触核蛋白抗体。 抗体可用于治疗突触核蛋白病如帕金森病（包括帕金森氏病的特发性和遗传性形式），弥漫性路易体疾病（DLBD），阿尔茨海默氏病的路易体变体（LBV），阿尔茨海默氏综合征和帕金森病，纯自主神经病 失败和多系统萎缩。
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