公开(公告)号：US20220024875A1

公开(公告)日：2022-01-27

申请号：US17495997

申请日：2021-10-07

Applicant: H. Lundbeck A/S

Inventor： Mikkel Fog Jacobsen ,  Martin Juhl ,  Frans Dennis Therkelsen ,  Kåre Søndergaard ,  Tobias Gylling Frihed

IPC: C07D215/06 ,  C07D317/60

Abstract: The present invention relates to a new process for manufacturing (6aR,10aR)-7-propyl-6,6 a,7,8,9,10,10a,11-octahydro-[1,3]dioxolo[4′,5′:5,6]benzo[1,2-g]quinoline with formula (Ib) below, (4aR,10aR)-1-Propyl-1,2,3,4,4a,5,10,10a-octahydro-benzo[g]quinoline-6,7-diol with formula (I) below and salts thereof. Both compounds are for use in the treatment of neurodegenerative diseases and disorders such as Parkinson's Disease. The invention also relates to new intermediate compounds of said process.

公开(公告)号：US11168056B2

公开(公告)日：2021-11-09

申请号：US16876966

申请日：2020-05-18

Applicant: H. Lundbeck A/S

Inventor： Mikkel Fog Jacobsen ,  Martin Juhl ,  Frans Dennis Therkelsen ,  Kåre Søndergaard ,  Tobias Gylling Frihed

IPC: C07D215/06 ,  C07D317/60

Abstract: The present invention relates to a new process for manufacturing (6aR,10aR)-7-propyl-6,6a,7,8,9,10,10a,11-octahydro-[1,3]dioxolo[4′,5′:5,6]benzo[1,2-g]quinoline with formula (Ib) below, (4aR,10aR)-1-Propyl-1,2,3,4,4a,5,10,10a-octahydro-benzo[g]quinoline-6,7-diol with formula (I) below and salts thereof. Both compounds are for use in the treatment of neurodegenerative diseases and disorders such as Parkinson's Disease. The invention also relates to new intermediate compounds of said process.

公开(公告)号：US20200369706A1

公开(公告)日：2020-11-26

申请号：US16876878

申请日：2020-05-18

Applicant: H. Lundbeck A/S

Inventor： Martin Juhl ,  Frans Dennis Therkelsen ,  Tobias Gylling Frihed

IPC: C07H15/26 ,  C07H1/00

Abstract: The present invention relates to a process for manufacturing (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(((4aR,10aR)-7-hydroxy-1-propyl-1,2,3,4,4a,5,10,10a-octahydrobenzo[g]quinolin-6-yl)oxy)tetrahydro-2H-pyran-2-carboxylic acid with the formula (Id) below and salts thereof The compound of formula (Id) is a prodrug of a catecholamine for use in treatment of neurodegenerative diseases and disorders such as Parkinson's Disease.The invention also relates to new intermediates of said process.