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公开(公告)号：US10233230B2
公开(公告)日：2019-03-19
申请号：US15511405
申请日：2015-09-16
发明人： Sang Youn Hwang , Jin Young Kim , Seung Su Kim , In Young Choi , Sung Youb Jung , Se Chang Kwon
摘要： The present invention relates to a pharmaceutical composition for the prevention or treatment of non-alcoholic fatty liver disease including a long-acting GLP-1/glucagon receptor dual agonist, and a method for preventing or treatment of non-alcoholic fatty liver disease including administering the composition. The composition of the present invention either has no side effect of weight gain or reduces the side effect of weight gain, which is a side-effect of conventional therapeutic agents for non-alcoholic fatty liver disease, and reduces the amount of administrations of a long-acting GLP-1/glucagon receptor dual agonist, thus greatly improving patient's convenience. In addition, the long-acting GLP-1/glucagon receptor dual agonist of the present invention improves in vivo sustainability and stability.
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公开(公告)号：US20180177850A1
公开(公告)日：2018-06-28
申请号：US15846395
申请日：2017-12-19
发明人： Sung Youb Jung , Jin-Sun Kim , Myung Hyun Jang , Sang Hyun Lee , In Young Choi , Se Chang Kwon
IPC分类号： A61K38/26 , A61K47/64 , C07K14/78 , A61K47/59 , A61K47/68 , C07K14/76 , A61K45/06 , A61K47/60 , A61K38/22 , C07K14/605
CPC分类号： A61K38/26 , A61K38/22 , A61K45/06 , A61K47/59 , A61K47/593 , A61K47/60 , A61K47/643 , A61K47/6435 , A61K47/68 , A61K47/6811 , C07K14/605 , C07K14/76 , C07K14/78
摘要： The present invention relates to a composition for preventing or treating hyperlipidemia, fatty liver disease or arteriosclerosis, comprising an oxyntomodulin derivative as an active ingredient. The oxyntomodulin derivative has a high ability to activate GLP-1 receptor and glucagon receptor compared to native oxyntomodulin and has the effects of reducing the blood total cholesterol, low-density cholesterol and triglyceride levels that were increased by high-fat diet, and increasing high-density cholesterol levels and the high-density cholesterol/low-density cholesterol ratio. Thus, the oxyntomodulin derivative can be effectively used for the treatment of hyperlipidemia and related diseases.
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公开(公告)号：US09901621B2
公开(公告)日：2018-02-27
申请号：US15086499
申请日：2016-03-31
发明人： Sung Youb Jung , Jin-Sun Kim , Myung Hyun Jang , Sang Hyun Lee , In Young Choi , Se Chang Kwon
IPC分类号： A61K38/22 , A61K47/48 , A61K38/26 , C07K14/605 , A61P3/06 , A61K45/06 , C07K14/76 , C07K14/78 , A61K47/60 , A61K47/59 , A61K47/64 , A61K47/68
CPC分类号： A61K38/26 , A61K38/22 , A61K45/06 , A61K47/59 , A61K47/593 , A61K47/60 , A61K47/643 , A61K47/6435 , A61K47/68 , A61K47/6811 , C07K14/605 , C07K14/76 , C07K14/78
摘要： The present invention relates to a composition for preventing or treating hyperlipidemia, fatty liver disease or arteriosclerosis, comprising an oxyntomodulin derivative as an active ingredient. The oxyntomodulin derivative has a high ability to activate GLP-1 receptor and glucagon receptor compared to native oxyntomodulin and has the effects of reducing the blood total cholesterol, low-density cholesterol and triglyceride levels that were increased by high-fat diet, and increasing high-density cholesterol levels and the high-density cholesterol/low-density cholesterol ratio. Thus, the oxyntomodulin derivative can be effectively used for the treatment of hyperlipidemia and related diseases.
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14.发明申请COMPOSITION FOR TREATING HYPERLIPIDEMIA COMPRISING OXYNTOMODULIN DERIVATIVE 审中-公开用于治疗包含氧自由基衍生物的高磷脂酰胆碱的组合物公开(公告)号：US20150182593A1
公开(公告)日：2015-07-02
申请号：US14415200
申请日：2013-07-25
发明人： Sung Youb Jung , Jin-Sun Kim , Myung Hyun Jang , Sang Hyun Lee , In Young Choi , Se Chang Kwon
CPC分类号： A61K38/26 , A61K38/22 , A61K45/06 , A61K47/59 , A61K47/593 , A61K47/60 , A61K47/643 , A61K47/6435 , A61K47/68 , A61K47/6811 , C07K14/605 , C07K14/76 , C07K14/78
摘要： The present invention relates to a composition for preventing or treating hyperlipidemia, fatty liver disease or arteriosclerosis, comprising an oxyntomodulin derivative as an active ingredient. The oxyntomodulin derivative has a high ability to activate GLP-1 receptor and glucagon receptor compared to native oxyntomodulin and has the effects of reducing the blood total cholesterol, low-density cholesterol and triglyceride levels that were increased by high-fat diet, and increasing high-density cholesterol levels and the high-density cholesterol/low-density cholesterol ratio. Thus, the oxyntomodulin derivative can be effectively used for the treatment of hyperlipidemia and related diseases.
摘要翻译： 本发明涉及用于预防或治疗高脂血症，脂肪肝疾病或动脉硬化的组合物，其包含胃泌酸调节素衍生物作为活性成分。 胃泌酸调节蛋白衍生物与天然胃泌酸调节素相比具有高活化GLP-1受体和胰高血糖素受体的能力，并且具有降低高脂肪饮食增加的血液总胆固醇，低密度胆固醇和甘油三酯水平的作用，并且增加高 密度胆固醇水平和高密度胆固醇/低密度胆固醇比值。 因此，胃泌酸调节蛋白衍生物可以有效地用于治疗高脂血症和相关疾病。
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公开(公告)号：US11925691B2
公开(公告)日：2024-03-12
申请号：US16484290
申请日：2018-02-07
发明人： Su Yeon Park , Dae Jin Kim , Sung Youb Jung , Yong Gyu Jung , Hyun Sik Yun
IPC分类号： A61K47/68 , A61K47/54 , A61K47/60 , C07D225/08
CPC分类号： A61K47/6889 , A61K47/545 , A61K47/60 , A61K47/6803 , C07D225/08
摘要： One aspect of the present invention provides a compound in which a functional group capable of binding to a globulin Fc region or a physiologically active polypeptide is introduced at one end of a non-peptidic polymer and a functional group capable of a click reaction is introduced at the other end; a polypeptide conjugate in which a physiologically active polypeptide binds to one end of the compound; a physiologically active polypeptide conjugate in which a physiologically active polypeptide and an immunoglobulin Fc region bind to both ends thereof by using the compound as a linker; and methods for preparing the same compound, polypeptide conjugate, and physiologically active polypeptide conjugate.
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公开(公告)号：US11530249B2
公开(公告)日：2022-12-20
申请号：US16832634
申请日：2020-03-27
发明人： Jaehyuk Choi , Min Young Kim , In Young Choi , Sung Youb Jung
IPC分类号： C07K14/605 , A61K47/62 , A61K47/68 , A61P1/00
摘要： A glucagon-like peptide-2 (GLP-2) derivative, a conjugate thereof, and a use thereof are disclosed. Additionally, a method for preparing a glucagon-like peptide-2 (GLP-2) derivative and a conjugate thereof is disclosed.
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公开(公告)号：US11135271B2
公开(公告)日：2021-10-05
申请号：US15540729
申请日：2015-12-30
发明人： Jung Kuk Kim , Jong Min Lee , Sang Yun Kim , Sung Min Bae , Sung Youb Jung , Se Chang Kwon
IPC分类号： A61K38/26 , C07K14/605 , A61K45/06
摘要： The present invention relates to a novel glucagon derivative peptide, and a composition for preventing or treating hypoglycemia containing the novel glucagon derivative peptide as an active ingredient. The glucagon derivative according to the present invention has improved physical properties due to the change in isoelectric point (pI) while being capable of maintaining an activity on glucagon receptors, and thus can improve patient compliance when used as a hypoglycemic agent, and is also suitable for administration in combination with other anti-obesity agents. Accordingly, the glucagon derivative according to the present invention can be effectively used for the prevention and treatment of hypoglycemia and obesity.
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公开(公告)号：US10973881B2
公开(公告)日：2021-04-13
申请号：US14894222
申请日：2014-05-29
发明人： Sung Youb Jung , Yong Ho Huh , Sung Hee Park , Jong Soo Lee , In Young Choi
摘要： The present invention relates to a modified IgG4 Fc fragment useful as a drug carrier. When the modified IgG4 Fc fragment of the present invention is combined with an arbitrary drug, the resulting drug conjugate can minimize the effector functions of the IgG4 Fc and the chain exchange with in vivo IgG while maintaining in vivo activity and improving in vivo duration of the drug conjugate.
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公开(公告)号：US10696725B2
公开(公告)日：2020-06-30
申请号：US15740668
申请日：2016-06-29
发明人： Jung Kuk Kim , Young Jin Park , In Young Choi , Sung Youb Jung
IPC分类号： A61K38/26 , A61K38/28 , C07K14/605 , A61K38/22 , A61K47/60 , A61K47/68 , A61P3/08 , A61P3/00 , A61P3/04
摘要： The present invention relates to a glucagon derivative, a long-acting conjugate of the glucagon derivative, and a use thereof.
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20.发明授权公开(公告)号：US10660940B2
公开(公告)日：2020-05-26
申请号：US14772493
申请日：2014-03-05
发明人： Myung Hyun Jang , Min Young Kim , Dae Jin Kim , Sung Youb Jung , Se Chang Kwon
摘要： A method for preparing a conjugate by linking a physiologically active polypeptide, a non-peptidyl polymer linker, and an immunoglobulin constant region via a covalent bond are disclosed. The method enables an efficient preparation of a physiologically active polypeptide conjugate, in which a salt is used in a coupling reaction to improve the problem of low production yield during preparation of the physiologically active polypeptide conjugate.
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