公开(公告)号：US3679655A

公开(公告)日：1972-07-25

申请号：US3679655D

申请日：1969-06-20

Applicant: HOECHST AG

Inventor： JAGER GEORG ,  GEIGER ROLF

IPC: C07K1/06 ,  C07K5/103 ,  C07C101/00 ,  C07C103/52 ,  C07C155/08

CPC classification number: C07K5/101 ,  C07K1/067 ,  Y02P20/55 ,  Y10S930/26

Abstract: A METHOD OF PROTECTING THE SULFUR ATOM OF CYSTEINE N PEPTIDE SYNTHESIS BY REACTION WITH B-(N,N-DISUBSTITUTED)AMINOETHYL ISOCYANATE IN WHICH ONE SUBSTITUENT IS METHYL OR EHTYL AND THE OTHER IS BENZYLOXYCARBONYL, T-BUTYLOXYCARBONYL, OR ADAMANTYLOXYCARBONYL. FOR REMOVAL OF THE PROTECTIVE GROUP, THE PEPTIDE IS TREATED WITH A STRONG ACID TO FORM THE ACID SALT OF THE CORRESPONDING MONOSUBSTITUTED N-ETHYL OR N-METHYL AMINO COMPOUND AND THEN MADE ALKALINE TO LIBERATE THE AMINE. THE PROTECTIVE GROUP CLEAVES INTRAMOLECULARLY WITH FORMATION OF A METHYL OR ETHYL-SUBSTITUTED IMIDAZOLONE AND THE PEPTIDE IN WHICH THE CYSTEINE SULFUR ATOM IS PRESENT AS SULFHYDRYL.

公开(公告)号：US3538070A

公开(公告)日：1970-11-03

申请号：US3538070D

申请日：1968-02-27

Applicant: HOECHST AG

Inventor： GEIGER ROLF ,  JAGER GEORG ,  SIEDEL WALTER

IPC: C07K1/06 ,  C07C101/00 ,  C07C103/52 ,  C07C125/04

CPC classification number: C07K1/065 ,  Y02P20/55 ,  Y10S930/15