公开(公告)号：US3679655A

公开(公告)日：1972-07-25

申请号：US3679655D

申请日：1969-06-20

Applicant: HOECHST AG

Inventor： JAGER GEORG ,  GEIGER ROLF

IPC: C07K1/06 ,  C07K5/103 ,  C07C101/00 ,  C07C103/52 ,  C07C155/08

CPC classification number: C07K5/101 ,  C07K1/067 ,  Y02P20/55 ,  Y10S930/26

Abstract: A METHOD OF PROTECTING THE SULFUR ATOM OF CYSTEINE N PEPTIDE SYNTHESIS BY REACTION WITH B-(N,N-DISUBSTITUTED)AMINOETHYL ISOCYANATE IN WHICH ONE SUBSTITUENT IS METHYL OR EHTYL AND THE OTHER IS BENZYLOXYCARBONYL, T-BUTYLOXYCARBONYL, OR ADAMANTYLOXYCARBONYL. FOR REMOVAL OF THE PROTECTIVE GROUP, THE PEPTIDE IS TREATED WITH A STRONG ACID TO FORM THE ACID SALT OF THE CORRESPONDING MONOSUBSTITUTED N-ETHYL OR N-METHYL AMINO COMPOUND AND THEN MADE ALKALINE TO LIBERATE THE AMINE. THE PROTECTIVE GROUP CLEAVES INTRAMOLECULARLY WITH FORMATION OF A METHYL OR ETHYL-SUBSTITUTED IMIDAZOLONE AND THE PEPTIDE IN WHICH THE CYSTEINE SULFUR ATOM IS PRESENT AS SULFHYDRYL.

公开(公告)号：US3538070A

公开(公告)日：1970-11-03

申请号：US3538070D

申请日：1968-02-27

Applicant: HOECHST AG

Inventor： GEIGER ROLF ,  JAGER GEORG ,  SIEDEL WALTER

IPC: C07K1/06 ,  C07C101/00 ,  C07C103/52 ,  C07C125/04

CPC classification number: C07K1/065 ,  Y02P20/55 ,  Y10S930/15

公开(公告)号：US3883500A

公开(公告)日：1975-05-13

申请号：US41031073

申请日：1973-10-29

Applicant: HOECHST AG

Inventor： GEIGER ROLF ,  JAGER GEORG

IPC: C07K14/575 ,  C07K1/113 ,  C07K14/62 ,  C07C103/52 ,  A61K17/04 ,  C07G7/00

CPC classification number: C07K14/62 ,  Y02P20/55 ,  Y10S930/26

Abstract: D R A W I N G
A method for making insulin and certain derivatives thereof from a compound of the formula (I)

D R A W I N G
wherein X is hydrogen or an S-protective group and n is an integer from two to four, which comprises cleaving any Sprotective groups present and dehydrogenating -SH groups to form S-S bonds to form a compound of the formula (II)

BRIDGE BY TREATING THE LATTER COMPOUND WITH AN ACID. Compounds of the formula II.

and then eliminating the

Abstract translation: 一种由式（I）化合物制备胰岛素及其某些衍生物的方法，其中X为氢或S-保护基，n为2至4的整数，其包括切断存在的任何S-保护基团并脱氢 - SH基团形成SS键以形成式（II）的化合物，然后通过用酸处理化合物来消除桥。 式II的化合物。