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    Cardioactive anhydrotalomethylosides and process for preparing them
    11.
    发明授权
    Cardioactive anhydrotalomethylosides and process for preparing them 失效
    心脏活性脱水甲基氯化物及其制备方法

    公开(公告)号：US3910882A

    公开(公告)日：1975-10-07

    申请号：US38266273

    申请日：1973-07-26

    Applicant: HOECHST AG

    Inventor： HAEDE WERNER ,  FRITSCH WERNER ,  STACHE ULRICH ,  LINDNER ERNST

    IPC: C07J19/00 ,  A61K20060101 ,  A61K31/585 ,  A61K31/704 ,  A61P7/10 ,  A61P9/04 ,  C07C20060101 ,  C07D20060101

    CPC classification number: C07J19/00

    Abstract: The invention relates to 3'', 4''-anhydro- Beta , Ltalomethylosides of the general formula I

    wherein R1 is methyl or formyl and R2 stands for Beta -H or Beta -OH, if there is no double bond in 4,5-position, and R3 is a butenolide or cumalin ring, a process for preparing them and their use in the treatment of cardiac and circulatory disturbances. The compounds are especially suitable for treating cardiac insufficiency, tachycardia and conduction defects.

    Abstract translation: 本发明涉及通式Ⅰ的3'，4'-脱氢-β，L-天门冬氨酸盐，其中R1是甲基或甲酰基，R2代表β-H或β--OH，如果4,5中没有双键 - 位，R3是丁烯内酯或坎加林环，其制备方法及其在治疗心脏和循环障碍中的应用。 该化合物特别适用于治疗心功能不全，心动过速和传导缺陷。

    Process for the manufacture of delta 14-20-keto-21-dialkoxy steroids
    12.
    发明授权
    Process for the manufacture of delta 14-20-keto-21-dialkoxy steroids 失效
    制造DELTA 14-20-酮二十二烷氧基甾体的方法

    公开(公告)号：US3900502A

    公开(公告)日：1975-08-19

    申请号：US15856671

    申请日：1971-06-30

    Applicant: HOECHST AG

    Inventor： RADSCHEIT KURT ,  STACHE ULRICH ,  FRITSCH WERNER ,  HAEDE WERNER

    IPC: A61K31/573 ,  A61K31/58 ,  C07C169/32

    CPC classification number: A61K31/573 ,  A61K31/58

    Abstract: Delta 14-20-KETO-21-DIALKOXY STEROIDS ARE PREPARED BY OXIDIZING 20-KETO-15 Alpha ,21-DIHYDROXY STEROIDS OF THE GENERAL FORMULA

    IN WHICH Y is an oxo group which may be ketalized, a

    GROUP WHICH MAY BE ETHERIFIED OR ESTERIFIED, A Delta 3-, Delta 2-, OR Delta 3,5-ENOL ETHER GROUP OR A Delta 3-, Delta 2-, OR Delta 3,5-ENAMINO GROUP, WHICH GROUPS MAY HAVE A DOUBLE BOND IN THE 4-POSITION, AND

    IS A LOWER ACYCLIC OR CYCLIC ACETAL GROUPING, ACETALIZING THE 15 Alpha -HYDROXY-20-KETO-21-OXO STEROIDS OBTAINED, REACTING THE 15 Alpha -HYDROXY-20-KETO-21-DIALKOXY STEROIDS THUS OBTAINED WITH SULFONIC ACID HALIDES AND TREATING THE 15-SULFONIC ACID ESTERS THUS OBTAINED WITH AGENTS SPLITTING OFF ACIDS. The products are valuable intermediates for the manufacture of medicaments.

    Digitoxigenin rhamnoside cyclocarbonates
    19.
    发明授权
    Digitoxigenin rhamnoside cyclocarbonates 失效
    Digitoxigenin鼠李糖苷环状碳酸酯

    公开(公告)号：US3872081A

    公开(公告)日：1975-03-18

    申请号：US37068573

    申请日：1973-06-18

    Applicant: HOECHST AG

    Inventor： STACHE ULRICH ,  HAEDE WERNER ,  FRITSCH WERNER ,  RADSCHEIT KURT ,  LINDNER ERNST

    IPC: C07J19/00 ,  A61K31/585 ,  A61K31/704 ,  A61P9/04 ,  C07D20060101 ,  C07C173/02

    Abstract: wherein R is hydrogen or alkanoyl or alkyl having 1 to 5 carbon atoms are described as well as two processes for their preparation. The compounds show positive inotropic action and are suitable for treating heart diseases.

    Digitoxigenin-3- Alpha -(L-rhamnopyranoside-2'',3''cyclocarbonates) of the general formula I

    Abstract translation: 对其中R是氢或烷酰基或具有1-5个碳原子的烷基的通式I的二氧化硫脲-3α-[L-鼠李糖吡喃糖苷-2'，3'-环状碳酸酯]以及它们的制备方法进行了描述。 这些化合物显示正性肌力作用，适用于治疗心脏病。

    PROCESS FOR THE MANUFACTURE OF {66 {11 {11 14-20-KETO-21-DIALKOXY STEROIDS
    20.
    发明授权
    PROCESS FOR THE MANUFACTURE OF {66 {11 {11 14-20-KETO-21-DIALKOXY STEROIDS 失效
    制备{66 {11 {11-14-20-酮二十二烷氧基甾体的方法

    公开(公告)号：US3682987A

    公开(公告)日：1972-08-08

    申请号：US3682987D

    申请日：1969-04-14

    Applicant: KURT RADSCHEIT ,  ULRICH STACHE ,  WERNER FRITSCH ,  WERNER HAEDE ,  HOECHST AG

    Inventor： RADSCHEIT KURT ,  STACHE ULRICH ,  FRITSCH WERNER ,  HAEDE WERNER

    IPC: A61K31/573 ,  A61K31/58 ,  C07C169/32

    CPC classification number: A61K31/573 ,  A61K31/58

    Abstract: DELTA 14-20-KETO-21-DIALKOXY STEROIDS ARE PREPARED BY OXIDIZING 20-KETO-15 alpha ,21-DIHYDROXY STEROIDS OF THE GENERAL FORMULA IN WHICH Y is an oxo group which may be ketalized, GROUP WHICH MAY BE ETHERIFIED OR ESTERIFIED, A DELTA 3-, DELTA 2-, OR DELTA 3,5-ENOL ETHER GROUP OR A DELTA 3-, DELTA 2-, OR DELTA 3,5-ENAMINO GROUP, WHICH GROUPS MAY HAVE A DOUBLE BOND IN THE 4-POSITION, AND IS A LOWER ACYCLIC OR CYCLIC ACETAL GROUPING, ACETALIZING THE 15 alpha -HYDROXY-20-KETO-21-OXO STEROIDS OBTAINED, REACTING THE 15 alpha -HYDROXY-20-KETO-21-DIALKOXY STEROIDS THUS OBTAINED WITH SULFONIC ACID HALIDES AND TREATING THE 15-SULFONIC ACID ESTERS THUS OBTAINED WITH AGENTS SPLITTING OFF ACIDS. The products are valuable intermediates for the manufacture of medicaments.

    Abstract translation: 通过氧化通用制剂的20-KETO-15α，21-二羟基甾体来制备DELTA 14-20-酮二十二烷氧基甾体，其中Y是可被缩合的氧代基团，其可以被醚化或被纯化， DELTA 3-，DELTA 2-或OR DELTA 3,5-ENOL ETHER GROUP或DELTA 3-，DELTA 2-或DELTA 3,5-ENAMINO集团，其组合可能在4位置有双重粘结， 并且是一种较低的ACYCLIC或循环乙酰基化，获得所获得的15α-羟基-20-酮二十一氧代甾族化合物，反应获得的15个α-羟基-20-酮二十二烷氧基异烟肼和治疗 这种15-磺基酸酯可以与分离出酸的试剂一起获得。 这些产品是制造药物的有价值的中间体。

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