公开(公告)号：US3674779A

公开(公告)日：1972-07-04

申请号：US3674779D

申请日：1970-05-08

Applicant: HOECHST AG

Inventor： STACHE ULRICH ,  RADSCHEIT KURT ,  FRITSCH WERNER ,  HAEDE WERNER ,  LINDNER ERNST

IPC: A41D27/20 ,  A61K31/585 ,  C07J19/00 ,  C07C173/02

CPC classification number: A61K31/585 ,  C07J19/00

Abstract: Process for the manufacture of 4-chloro-3-oxo-14 Beta -hydroxyor 4-chloro-3,14 Beta -dihydroxy-carda-4,20(22)dienolides wherein 3-oxo-carda-4,14,20(22)-trienolides are at first treated with chlorine, the compounds obtained are converted by hydrogenolysis into 3-oxo-4-chloro-carda-4,14,20-trienolides, these are treated with N-bromo-acid amides, and the 3-oxo-4chloro-14 Beta -hydroxy-15 Alpha -bromo-carda-4,20(22)-dienolides thus obtained are treated with Raney nickel and may be reduced.

公开(公告)号：US3641009A

公开(公告)日：1972-02-08

申请号：US3641009D

申请日：1969-12-02

Applicant: HOECHST AG

Inventor： RADSCHEIT KURT ,  STACHE ULRICH ,  HAEDE WERNER ,  FRITSCH WERNER ,  LINDNER ERNST

IPC: C07J19/00 ,  A47J47/04 ,  A61K31/585 ,  C07J71/00 ,  C07C173/04

CPC classification number: A61K31/585 ,  A47J47/04 ,  C07J71/00

Abstract: CARDIO-ACTIVE OXIDO-BUFADIENOLIDES OF THE FORMULA

3-(R-O-),4,5-(-O-),14-(HO-),17-(2-(O=)-2H-PYRAN-5-YL)

ANDROSTANE

WHEREIN R IS HYDROGEN OR LOWER ACYL, AND A METHOD FOR MAKING THEM.

公开(公告)号：US3565990A

公开(公告)日：1971-02-23

申请号：US3565990D

申请日：1968-02-13

Applicant: HOECHST AG

Inventor： GROEBEL ALFRED ,  LINDNER ERNST

IPC: A61K20060101 ,  A61K36/00 ,  A61K36/24 ,  C07G5/00 ,  A61K27/14

CPC classification number: A61K36/24

Abstract: A PHARMACOLOGICALLY ACTIVE SUBSTANCE HAVING BLOOD PRESSURE LOWERING ACTIVITY, ISOLATED FROM CABUCALA MADAGASCARIENSIS AND A PROCESS FOR ISOLATING SAID SUBSTANCE FROM THE PLANT MATERIAL BY ALCOHOL EXTRACTION.

公开(公告)号：US3914213A

公开(公告)日：1975-10-21

申请号：US41174773

申请日：1973-11-01

Applicant: HOECHST AG

Inventor： STACHE ULRICH ,  FRITSCH WERNER ,  HAEDE WERNER ,  LINDNER ERNST

IPC: C07J41/00 ,  A61K31/585 ,  C07J17/00 ,  C07J19/00

Abstract: Cardenolido-3-(4''-amino-2'', 3'', 4''-tridesoxy-glycosides) of the general formula

WHEREIN R1 stands for a steroid radical of the 3hydroxycardenolide series, R2 stands for hydrogen, lower alkyl, alkenyl, cycloalkyl, phenyl, benzyl, phenylethyl, lower aliphatic acyl, or one of the acid radicals of benzoic acid, cinnamic acid or cyclohexane-carboxylic acid, and R3 stands for methyl, the CH2OR2-group or hydrogen, and a process for their preparation are described. The compounds have valuable pharmaceutical properties.

Abstract translation: 通式为：WHEREIN R1代表3-羟基僵硬醚系列的类固醇基的卡固伦多-3- [4'-氨基-2'，3'，4'-三酰氧基 - 糖苷]，R2代表氢，低级烷基，烯基 ，环烷基，苯基，苄基，苯基乙基，低级脂族酰基或苯甲酸，肉桂酸或环己烷羧酸的酸基之一，R 3代表甲基，CH 2 OR 2 - 基或氢，及其制备方法 被描述。 这些化合物具有有价值的药物性质。

公开(公告)号：US3904599A

公开(公告)日：1975-09-09

申请号：US38263973

申请日：1973-07-26

Applicant: HOECHST AG

Inventor： STACHE ULRICH ,  FRITSCH WERNER ,  HAEDE WERNER ,  RADSCHEIT KURT ,  LINDNER ERNST

IPC: C07J19/00 ,  A61K20060101 ,  A61K31/585 ,  A61P1/08 ,  A61P7/10 ,  A61P9/04 ,  A61P9/14 ,  C07C20060101 ,  C07D20060101 ,  C07J20060101 ,  C07C173/00

CPC classification number: Y10S514/867 ,  Y10S514/869 ,  Y10S514/87

Abstract: Cardenolide-3-(2''-desoxy-glycosides) of the formula

useful in the treatment of cardiac and circulatory diseases, wherein R1 is a steroid of the 3-hydroxy-cardenolide series, R2 is hydrogen, lower aliphatic acyl, or aromatic acyl, and R3 is hydrogen, methyl, or -CH2OR2.

公开(公告)号：US3681344A

公开(公告)日：1972-08-01

申请号：US3681344D

申请日：1969-12-02

Applicant: HOECHST AG

Inventor： RADSCHEIT KURT ,  HAEDE WERNER ,  FRITSCH WERNER ,  LINDNER ERNST ,  STACHE URICH

IPC: A61K31/58 ,  A61K31/585 ,  C07J19/00 ,  C07J71/00 ,  G09F15/00 ,  C07C173/04

CPC classification number: A61K31/58 ,  A61K31/585 ,  C07J19/00 ,  C07J71/00 ,  G09F15/00

Abstract: Cardioactive oxido-bufadienolides of the formula

WHEREIN R is hydrogen or lower acyl. Methods of making such compounds.

Abstract translation: 式WHEREIN R是氢或低级酰基的心脏活性氧化 - 巴芬德内酯。 制备此类化合物的方法。

公开(公告)号：US3655886A

公开(公告)日：1972-04-11

申请号：US3655886D

申请日：1970-08-11

Applicant: HOECHST AG

Inventor： GROEBEL ALFRED ,  LINDNER ERNST

IPC: A61K36/00 ,  A61K36/54 ,  C07G11/00 ,  C07G99/00 ,  A61K27/14

CPC classification number: A61K36/54

Abstract: A PHARMACOLOGICALLY ACTIVE SUBSTANCE ISOLATED FROM THE BARK OF RAVENSARA AROMATICA BY EXTRACTION OF THE BARK WITH A LOWER ALCOHOL, EVAPORATION OF THE EXTRACT TO GIVE A SOLID RESIDUE, AND CHROMATOGRAPHY OF THE RESIDUE.

公开(公告)号：US3565955A

公开(公告)日：1971-02-23

申请号：US3565955D

申请日：1967-10-23

Applicant: HOECHST AG

Inventor： EHRHART GUSTAV ,  LINDNER ERNST ,  OTT HEINRICH

IPC: C07C93/08

CPC classification number: B41M5/136

Abstract: BASICALLY SUBSTITUTED DIPHENYL-METHYL ETHERS OF THE FORMULA

1-((R-PHENYL)-CH(-PHENYLENE-R1)-O-CH2-CH2-N(-CH3)-

CH(-CH3)-CH2-),3-(CH3-O-),R4-BENZENE

IN WHICH R AND R1 ARE HYDROGEN, CHLORINE, BROMINE, HYDROXYL, ALKYL OF 1 TO 3 CARBON ATOMS, OR ALKOXY OF 1 TO 3 CARBON ATOMS, AND R4 IS HYDROGEN OR METHOXY HAVING BENEFICIAL PHYSIOLOGICAL ACTIVITY IN THE TREATMENT OF HEART AND CIRCULATORY DISEASES.