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    Benzodiazepine-diones, a process for their production and their use as medicaments
    11.
    发明授权
    Benzodiazepine-diones, a process for their production and their use as medicaments 失效
    苯二氮卓类药物，其生产过程及其用作药物

    公开(公告)号：US4187306A

    公开(公告)日：1980-02-05

    申请号：US922419

    申请日：1978-07-06

    申请人： Karl H. Mayer ,  Helmut Heitzer ,  Friedrich Hoffmeister ,  Arend Heise ,  Stanislav Kazda

    发明人： Karl H. Mayer ,  Helmut Heitzer ,  Friedrich Hoffmeister ,  Arend Heise ,  Stanislav Kazda

    IPC分类号： A61K31/55 ,  A61P25/04 ,  A61P25/20 ,  A61P25/28 ,  A61P29/00 ,  C07D239/91 ,  C07D487/04 ,  C07D471/04

    CPC分类号： C07D487/04 ,  C07D239/91 ,  Y10S514/916

    摘要： The invention covers compounds of the formula ##STR1## in which R.sup.1 and R.sup.5 each represents 0, 1, 2, 3 or 4 of the following substituents: alkyl, hydroxyl, acyloxy, alkoxy, nitro, amino, alkylamino, dialkylamino, acylamino, acylalkylamino, alkoxycarbonylamino, halogen, trifluoromethyl, cyano, carboxyl, alkoxycarbonyl, aminocarbonyl, alkylaminocarbonyl, dialkylaminocarbonyl, aminosulphonyl, alkylaminosulphonyl, dialkylaminoamino, R.sup.2 is hydrogen, optionally substituted alkyl, aralkyl or aryl or heterocyclo-alkyl, acyl or alkoxycarbonyl, and R.sup.3 and R.sup.4 are each hydrogen, or optionally substituted alkyl, aralkyl, aryl or hetero-aryl, are useful as medicaments which have an action on the central nervous system, in particular as, for example, tranquilizers and/or antiamnesics. Also included in the invention are methods for preparing said compounds, compositions containing them and methods for the use of said compounds and compositions.

    摘要翻译： 本发明涵盖下式的化合物，其中R 1和R 5各自表示0,1,2,3或4个以下取代基：烷基，羟基，酰氧基，烷氧基，硝基，氨基，烷基氨基，二烷基氨基，酰氨基，酰基烷基氨基 烷氧基羰基，氨基羰基，氨基磺酰基，烷基氨基磺酰基，二烷基氨基氨基，R2是氢，任意取代的烷基，芳烷基或芳基或杂环烷基，酰基或烷氧基羰基，R3和R4是 每个氢或任选取代的烷基，芳烷基，芳基或杂芳基可用作对中枢神经系统具有作用的药物，特别是例如镇定剂和/或抗病毒药物。 本发明还包括制备所述化合物的方法，含有它们的组合物和使用所述化合物和组合物的方法。