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1.发明授权
公开(公告)号：US4110472A
公开(公告)日：1978-08-29
申请号：US732118
申请日：1976-10-13
IPC分类号： A61K31/135 , A61K20060101 , A61K31/075 , A61K31/13 , A61K31/138 , A61K31/24 , A61K31/42 , A61K31/421 , A61K31/535 , A61P9/00 , A61P43/00 , C07C20060101 , C07C9/08 , C07C67/00 , C07C213/00 , C07C217/32 , C07C217/34 , C07D261/02 , C07D263/02 , C07D263/06 , C07D263/14 , C07D263/24 , C08G20060101 , C08G8/16 , A01N9/24 , C07C93/06
CPC分类号： C07C217/34 , C07C217/36 , C07C2103/18
摘要： N-Diphenylmethyl and o-biphenylenemethyl derivatives of 1-(disubstituted phenoxy)-3-amino-2-hydroxypropane and their salts are useful for combatting cerebrovascular insufficiency and producing psychostimulation in humans and other animals. The compounds, of which 1-(2-methoxy-4-allylphenoxy)-2-hydroxy-3-diphenylmethylamino-propane is a typical embodiment, can be prepared by a number of synthetic routes.
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公开(公告)号：US4070494A
公开(公告)日：1978-01-24
申请号：US640581
申请日：1975-12-15
IPC分类号： A61K47/38 , A61K9/02 , A61K9/20 , A61K31/135 , A61K31/215 , A61K31/40 , A61K31/445 , A61K45/08 , A01N17/00 , G01N1/00 , G01N33/16
CPC分类号： A61K9/02 , A61K31/135 , A61K31/137 , A61K31/215 , A61K31/40 , A61K31/445 , A61K31/60 , A61K9/2054 , Y10S514/944 , Y10S514/96 , Y10S514/974
摘要： Enteral pharmaceutical compositions containing medicinal agents having parenteral abuse potential are rendered resistant to aqueous extraction through the incorporation of a sufficient amount of a nontoxic, water gelable material. Attempts to extract the medicinal agent for parenteral abuse are thus inhibited or prevented since the material gels in the presence of water leaving no filterable liquid.
摘要翻译： 含有具有非肠道滥用潜力的药物的肠内药物组合物通过加入足量的无毒的水可胶化材料使其耐水萃取。 因此，由于材料在水的存在下凝胶不会有可过滤的液体，所以尝试提取肠胃外滥用的药剂因此被抑制或防止。
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