公开(公告)号：US06491655B1

公开(公告)日：2002-12-10

申请号：US09516769

申请日：2000-03-01

申请人： Harvey B. Pollard ,  Bette S. Pollard

发明人： Harvey B. Pollard ,  Bette S. Pollard

IPC分类号： A61M3700

CPC分类号： A61M1/3472 ,  A61M1/1678 ,  A61M1/28 ,  A61M1/3475 ,  A61M1/3486 ,  A61M2202/0449 ,  A61M2202/0452 ,  B01D69/02 ,  B01D2325/48 ,  A61M2202/0035 ,  A61M2202/0078

摘要： The present invention provides a method for treating Hemophilia A or B which comprises implanting in fluid communication with the bloodstream of a mammal in need of such treatment a permeable membrane having one or more walls, a hollow chamber therewithin, a plurality of holes extending through the walls of the membrane and permitting fluid to enter and exit the chamber of the membrane, each of the holes being sized so that it is large enough to permit inactive Factor VII to enter the chamber of the membrane and activated Factor VIIa to exit the chamber of the membrane but small enough to prevent fibrinogen from entering the chamber of the membrane, a plurality of supports being disposed within the chamber, and an effective amount of a Factor VII activator or a source of the activator being bound to the supports, wherein inactive factor VII in blood passing through the membrane becomes activated into Factor VIIa upon contact with the activator within the chamber. The present invention also provides a method for treating Hemophilia A or B extracorporeally. The present invention further provides methods for treating AIDS as well as permeable membranes for use in the methods above.

摘要翻译： 本发明提供了一种治疗血友病A或B的方法，其包括与需要这种治疗的哺乳动物的血液流体连通地植入，该渗透膜具有一个或多个壁，其中的中空室，多个孔延伸通过 膜的壁并且允许流体进入和离开膜的室，每个孔的尺寸使得其足够大以允许非活性因子VII进入膜的腔室并激活因子VIIa以离开膜的室 膜，但足够小以防止纤维蛋白原进入膜的腔室，多个支撑件设置在腔室内，并且有效量的因子VII活化剂或活化剂源与载体结合，其中非活性因子 通过膜的血液中的VII与活化剂在室内接触时被激活成因子VIIa。本发明a 还提供了一种治疗血友病A或B体外的方法。 本发明还提供了用于治疗AIDS的方法以及用于上述方法的渗透膜。

公开(公告)号：US5908399A

公开(公告)日：1999-06-01

申请号：US772034

申请日：1996-09-26

申请人： Harvey B. Pollard

发明人： Harvey B. Pollard

IPC分类号： A61M1/16 ,  A61M1/34 ,  B01D69/02 ,  A61M37/00

CPC分类号： B01D69/02 ,  A61M1/3472 ,  A61M1/3475 ,  A61M1/3486 ,  A61M1/1678 ,  A61M2202/0449 ,  A61M2202/0452 ,  Y10S436/811

摘要： The present invention provides a method for treating Hemophilia A or B which comprises implanting in fluid communication with the bloodstream of a mammal in need of such treatment a permeable membrane having one or more walls, a hollow chamber therewithin, a plurality of holes extending through the walls of the membrane and permitting fluid to enter and exit the chamber of the membrane, each of the holes being sized so that it is large enough to permit inactive Factor VII to enter the chamber of the membrane and activated Factor VIIa to exit the chamber of the membrane but small enough to prevent fibrinogen from entering the chamber of the membrane, a plurality of supports being disposed within the chamber, and an effective amount of a Factor VII activator or a source of the activator being bound to the supports, wherein inactive Factor VII in blood passing through the membrane becomes activated into Factor VIIa upon contact with the activator within the chamber.The present invention also provides a method for treating Hemophilia A or B extracorporeally. The present invention further provides methods for treating AIDS as well as permeable membranes for use in the methods above.

摘要翻译： 本发明提供了一种治疗血友病A或B的方法，其包括与需要这种治疗的哺乳动物的血液流体连通地植入，该渗透膜具有一个或多个壁，其中的中空室，多个孔延伸通过 膜的壁并且允许流体进入和离开膜的室，每个孔的尺寸使得其足够大以允许非活性因子VII进入膜的腔室并激活因子VIIa以离开膜的室 膜，但足够小以防止纤维蛋白原进入膜的腔室，多个支撑件设置在腔室内，并且有效量的因子VII活化剂或活化剂源与载体结合，其中非活性因子 与血液中的活化剂接触时，通过膜的血液中的VII被激活成因子VIIa。 本发明还提供一种体外治疗血友病A或B的方法。 本发明还提供了用于治疗AIDS的方法以及用于上述方法的渗透膜。