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    Method and apparatus for filtering suspensions of medical and biological fluids or the like
    1.
    发明申请
    Method and apparatus for filtering suspensions of medical and biological fluids or the like 有权
    用于过滤医疗和生物流体等的悬浮液的方法和装置

    公开(公告)号：US20020033367A1

    公开(公告)日：2002-03-21

    申请号：US09954734

    申请日：2001-09-18

    申请人： Baxter International Inc.

    发明人： Paul R. Prince ,  Michael O. Pekkarinen ,  David Bellamy JR. ,  Shmuel Sternberg

    IPC分类号： B01D061/00

    CPC分类号： B01D65/08 ,  A61M1/262 ,  A61M1/265 ,  A61M1/34 ,  A61M1/3403 ,  A61M1/341 ,  A61M2202/0429 ,  A61M2202/0439 ,  A61M2205/3334 ,  B01D39/1692 ,  B01D61/147 ,  B01D61/22 ,  B01D63/16 ,  B01D69/02 ,  B01D2321/20 ,  B01D2321/2025 ,  B01D2321/2058 ,  B01D2321/2066 ,  A61M2202/0042 ,  A61M2202/0035

    摘要： A method and apparatus for filtering suspensions of medical and biological fluids, one aspect of which is separating a suspension comprising at least two types of particles which are differently sized or shaped and in which the first type of particle may be deformable at a relatively lower force and/or faster rate than the second type of particle. A filter member is provided having substantially precisely dimensioned pore sizes, with the pores being dimensioned to allow passage of the first type of suspended particle without distortion or only minimal distortion and passage of the second type of particle only with substantial distortion. Because the filter membrane has precisely dimensioned pores, with spacing between the pores being maintained despite the smaller interval between the pores, the porosity of the membrane may be much greater than nominal pore size membranes, allowing faster filtration rates and/or smaller membranes for a given filtration rate, while reducing the exposure time of the cells within the shear environment, and consequently reducing particle damage. Various methods for preventing clogging of the membrane are also disclosed.

    摘要翻译： 一种用于过滤医疗和生物流体悬浮液的方法和装置，其一个方面是分离包含不同尺寸或形状的至少两种类型的颗粒的悬浮液，其中第一类型的颗粒可以以相对较低的力 和/或比第二类型的颗粒更快的速率。 提供具有基本上精确尺寸的孔径的过滤构件，其中孔的尺寸被设计成允许第一类型悬浮颗粒的通过，而不会产生变形，或仅仅具有基本变形的第二类型的颗粒的最小变形和通过。 因为过滤膜具有精确尺寸的孔，尽管孔之间的间隔较小，孔之间的间隔保持不变，膜的孔隙率可能远大于标称孔径膜，允许更快的过滤速率和/或较小的膜用于 给定的过滤速率，同时减少细胞在剪切环境中的暴露时间，从而减少颗粒损伤。 还公开了防止膜堵塞的各种方法。

    Method for treating hemophilia A and B and AIDS and devices used therein
    2.
    发明授权
    Method for treating hemophilia A and B and AIDS and devices used therein 有权
    治疗A型和B型血友病的方法及其中使用的装置

    公开(公告)号：US06174299B1

    公开(公告)日：2001-01-16

    申请号：US09205964

    申请日：1998-12-04

    申请人： Harvey B. Pollard ,  Bette S. Pollard

    发明人： Harvey B. Pollard ,  Bette S. Pollard

    IPC分类号： A61M3700

    CPC分类号： B01D69/02 ,  A61M1/1678 ,  A61M1/3472 ,  A61M1/3475 ,  A61M1/3486 ,  A61M2202/0449 ,  A61M2202/0452 ,  Y10S436/811 ,  A61M2202/0035 ,  A61M2202/0078

    摘要： The present invention provides a method for treating Hemophilia A or B which comprises implanting in fluid communication with the bloodstream of a mammal in need of such treatment a permeable membrane having one or more walls, a hollow chamber therewithin, a plurality of holes extending through the walls of the membrane and permitting fluid to enter and exit the chamber of the membrane, each of the holes being sized so that it is large enough to permit inactive Factor VII to enter the chamber of the membrane and activated Factor VIIa to exit the chamber of the membrane but small enough to prevent fibrinogen from entering the chamber of the membrane, a plurality of supports being disposed within the chamber, and an effective amount of a Factor VII activator or a source of the activator being bound to the supports, wherein inactive Factor VII in blood passing through the membrane becomes activated into Factor VIIa upon contact with the activator within the chamber. The present invention also provides a method for treating Hemophilia A or B extracorporeally. The present invention further provides methods for treating AIDS as well as permeable membranes for use in the methods above.

    摘要翻译： 本发明提供了一种治疗血友病A或B的方法，其包括与需要这种治疗的哺乳动物的血液流体连通地植入，该渗透膜具有一个或多个壁，其中的中空室，多个孔延伸通过 膜的壁并且允许流体进入和离开膜的室，每个孔的尺寸使得其足够大以允许非活性因子VII进入膜的腔室并激活因子VIIa以离开膜的室 膜，但足够小以防止纤维蛋白原进入膜的腔室，多个支撑件设置在腔室内，并且有效量的因子VII活化剂或活化剂源与载体结合，其中非活性因子 通过膜的血液中的VII与活化剂在室内接触时被激活成因子VIIa。本发明a 还提供了一种治疗血友病A或B体外的方法。 本发明还提供了用于治疗AIDS的方法以及用于上述方法的渗透膜。

    Methods for treating hemophilia A and B and AIDS and devices used therein
    6.
    发明授权
    Methods for treating hemophilia A and B and AIDS and devices used therein 有权
    治疗A型和B型血友病的方法及其中使用的装置

    公开(公告)号：US06491655B1

    公开(公告)日：2002-12-10

    申请号：US09516769

    申请日：2000-03-01

    申请人： Harvey B. Pollard ,  Bette S. Pollard

    发明人： Harvey B. Pollard ,  Bette S. Pollard

    IPC分类号： A61M3700

    CPC分类号： A61M1/3472 ,  A61M1/1678 ,  A61M1/28 ,  A61M1/3475 ,  A61M1/3486 ,  A61M2202/0449 ,  A61M2202/0452 ,  B01D69/02 ,  B01D2325/48 ,  A61M2202/0035 ,  A61M2202/0078

    摘要： The present invention provides a method for treating Hemophilia A or B which comprises implanting in fluid communication with the bloodstream of a mammal in need of such treatment a permeable membrane having one or more walls, a hollow chamber therewithin, a plurality of holes extending through the walls of the membrane and permitting fluid to enter and exit the chamber of the membrane, each of the holes being sized so that it is large enough to permit inactive Factor VII to enter the chamber of the membrane and activated Factor VIIa to exit the chamber of the membrane but small enough to prevent fibrinogen from entering the chamber of the membrane, a plurality of supports being disposed within the chamber, and an effective amount of a Factor VII activator or a source of the activator being bound to the supports, wherein inactive factor VII in blood passing through the membrane becomes activated into Factor VIIa upon contact with the activator within the chamber. The present invention also provides a method for treating Hemophilia A or B extracorporeally. The present invention further provides methods for treating AIDS as well as permeable membranes for use in the methods above.

    摘要翻译： 本发明提供了一种治疗血友病A或B的方法，其包括与需要这种治疗的哺乳动物的血液流体连通地植入，该渗透膜具有一个或多个壁，其中的中空室，多个孔延伸通过 膜的壁并且允许流体进入和离开膜的室，每个孔的尺寸使得其足够大以允许非活性因子VII进入膜的腔室并激活因子VIIa以离开膜的室 膜，但足够小以防止纤维蛋白原进入膜的腔室，多个支撑件设置在腔室内，并且有效量的因子VII活化剂或活化剂源与载体结合，其中非活性因子 通过膜的血液中的VII与活化剂在室内接触时被激活成因子VIIa。本发明a 还提供了一种治疗血友病A或B体外的方法。 本发明还提供了用于治疗AIDS的方法以及用于上述方法的渗透膜。

    Method and apparatus for filtering suspension of medical and biological fluids or the like
    9.
    发明授权
    Method and apparatus for filtering suspension of medical and biological fluids or the like 有权
    用于过滤医疗和生物流体等的悬浮液的方法和装置

    公开(公告)号：US06491819B2

    公开(公告)日：2002-12-10

    申请号：US09954734

    申请日：2001-09-18

    申请人： Paul R. Prince ,  Michael O. Pekkarinen ,  David Bellamy, Jr. ,  Shmuel Sternberg

    发明人： Paul R. Prince ,  Michael O. Pekkarinen ,  David Bellamy, Jr. ,  Shmuel Sternberg

    IPC分类号： B01D6114

    CPC分类号： B01D65/08 ,  A61M1/262 ,  A61M1/265 ,  A61M1/34 ,  A61M1/3403 ,  A61M1/341 ,  A61M2202/0429 ,  A61M2202/0439 ,  A61M2205/3334 ,  B01D39/1692 ,  B01D61/147 ,  B01D61/22 ,  B01D63/16 ,  B01D69/02 ,  B01D2321/20 ,  B01D2321/2025 ,  B01D2321/2058 ,  B01D2321/2066 ,  A61M2202/0042 ,  A61M2202/0035

    摘要： An apparatus is disclosed for separating a suspension comprising at least two types of particles which are differently sized or shaped and in which the first type of particle may be deformable at a relatively lower force or faster rate than the second type of particle. A housing is provided having a generally cylindrical inner surface in which is mounted a rotor having a generally cylindrical outer surface. The outer surface of the rotor is spaced from the inner surface of the housing to define a suspension processing gap. A filter membrane is provided on the surface of the rotor or the housing that has pores with substantially precisely dimensioned shapes and sizes to correspond substantially to the shape of the first type of particle, thus allowing passage of the first type of particle and blocking passage of the second type of particle. A suspension is directed into the processing gap for either a selected residence time in contact with the filter membrane and/or at a selected force.

    摘要翻译： 公开了一种用于分离包含至少两种不同尺寸或形状的颗粒的悬浮液的装置，其中第一类型的颗粒可以以比第二类型的颗粒更低的力或更快的速率变形。 提供具有大致圆柱形内表面的壳体，其中安装有具有大致圆柱形外表面的转子。 转子的外表面与壳体的内表面间隔开以限定悬挂处理间隙。 在转子或壳体的表面上提供过滤膜，其具有基本上精确尺寸的形状和尺寸的孔，其基本上对应于第一类型的颗粒的形状，从而允许第一类型的颗粒和阻挡通道 第二种类型的粒子。 将悬浮液引导到处理间隙中以选择与过滤膜接触的停留时间和/或以选定的力。

    Method of reducing the possibility of transmission of spongiform encephalopathy diseases by blood products
    10.
    发明授权
    Method of reducing the possibility of transmission of spongiform encephalopathy diseases by blood products 失效
    通过血液制品降低海绵状脑病传播的可能性的方法

    公开(公告)号：US06197207B1

    公开(公告)日：2001-03-06

    申请号：US08861859

    申请日：1997-05-21

    申请人： John Chapman ,  Jerry Fisher

    发明人： John Chapman ,  Jerry Fisher

    IPC分类号： B01D6114

    CPC分类号： A61M1/02 ,  A61L2/0017 ,  A61M2202/0439 ,  B01D21/262 ,  B01D61/147 ,  B01D2221/10 ,  A61M2202/0035 ,  A61M2202/0042

    摘要： Methods for reducing or preventing the transmission of transmissible spongiform encephalopathy through blood or blood products are provided. The methods require the intact removal of leukocytes that are present in a blood product or an intermediate of a blood product prior to administering the blood product to a patient. To prevent or reduce the transmission of transmissible spongiform encephalopathies disease substantially all leukocytes are removed intact without significant lysis of such leukocytes.

    摘要翻译： 提供减少或防止通过血液或血液制品传播传染性海绵状脑病的方法。 在向患者施用血液制品之前，这些方法需要完整地去除存在于血液制品或血液制品中间体中的白细胞。 为了防止或减少传染性海绵状脑病的传播，基本上所有的白细胞完整地被去除而没有这种白细胞的明显裂解。