公开(公告)号：US20110086423A1

公开(公告)日：2011-04-14

申请号：US12815125

申请日：2010-06-14

申请人： Rene Daniel ,  Anna Marie Skalka ,  Gary D. Kao ,  Giuseppe Nunnari ,  Roger J. Pomerantz

发明人： Rene Daniel ,  Anna Marie Skalka ,  Gary D. Kao ,  Giuseppe Nunnari ,  Roger J. Pomerantz

IPC分类号： C12N5/071

CPC分类号： C12Q1/485 ,  C12Q1/18

摘要： Cellular targets for anti-retroviral drug development are disclosed. The cellular targets comprise ATR kinase and its relevant substrates, based on the identification of the ATR kinase as required for the final step of retroviral DNA integration. Assays for identifying modulators of retroviral integration via the ATR kinase pathway are disclosed, as well as modulators identified by such assays. Pharmaceutical preparations and methods of their use in treating retroviral infection are also disclosed.

摘要翻译： 公开了用于抗逆转录病毒药物开发的细胞靶标。 基于逆转录病毒DNA整合的最终步骤所需的ATR激酶的鉴定，细胞靶标包含ATR激酶及其相关底物。 公开了通过ATR激酶途径鉴定逆转录病毒整合的调节剂的测定，以及通过这些测定法鉴定的调节剂。 还公开了其用于治疗逆转录病毒感染的药物制剂及其用途。

公开(公告)号：US07736848B2

公开(公告)日：2010-06-15

申请号：US11093692

申请日：2005-03-30

申请人： Rene Daniel ,  Anna Marie Skalka ,  Gary D. Kao ,  Giuseppe Nunnari ,  Roger J. Pomerantz

发明人： Rene Daniel ,  Anna Marie Skalka ,  Gary D. Kao ,  Giuseppe Nunnari ,  Roger J. Pomerantz

IPC分类号： C12N1/21 ,  C12Q1/701

CPC分类号： C12Q1/485 ,  C12Q1/18

摘要： Cellular targets for anti-retroviral drug development are disclosed. The cellular targets comprise ATR kinase and its relevant substrates, based on the identification of the ATR kinase as required for the final step of retroviral DNA integration. Assays for identifying modulators of retroviral integration via the ATR kinase pathway are disclosed, as well as modulators identified by such assays. Pharmaceutical preparations and methods of their use in treating retroviral infection are also disclosed.

摘要翻译： 公开了用于抗逆转录病毒药物开发的细胞靶标。 基于逆转录病毒DNA整合的最终步骤所需的ATR激酶的鉴定，细胞靶标包含ATR激酶及其相关底物。 公开了通过ATR激酶途径鉴定逆转录病毒整合的调节剂的测定，以及通过这些测定法鉴定的调节剂。 还公开了其用于治疗逆转录病毒感染的药物制剂及其用途。