公开(公告)号：US20120301858A1

公开(公告)日：2012-11-29

申请号：US13576428

申请日：2011-01-27

Applicant: Se Hyung Park ,  Lae Hyun Kim ,  Seung Jae Shin ,  Deuk Hee Lee ,  Wan Joo Park ,  Hyun Chul Cho ,  Hyun Jeong Kim

Inventor： Se Hyung Park ,  Lae Hyun Kim ,  Seung Jae Shin ,  Deuk Hee Lee ,  Wan Joo Park ,  Hyun Chul Cho ,  Hyun Jeong Kim

IPC: G09B23/28 ,  G09B23/30

CPC classification number: A61M5/46 ,  G09B23/285

Abstract: Provided is an injection simulation system and method. The system includes a syringe comprising an injection needle, a haptic unit which measures an insertion angle and insertion depth of the injection needle, and which comprises a motor unit that is driven by a haptic force corresponding to the measured insertion angle and insertion depth. The system also includes a control unit which calculates the haptic force corresponding to the insertion angle and the insertion depth, and transmits the calculated haptic force to the motor unit of the haptic unit.

Abstract translation: 提供了一种注射模拟系统和方法。 该系统包括注射器，其包括注射针，测量注射针的插入角度和插入深度的触觉单元，并且包括由对应于测量的插入角度和插入深度的触觉力驱动的马达单元。 该系统还包括控制单元，其计算与插入角度和插入深度相对应的触觉力，并将计算出的触觉力传递到触觉单元的电动机单元。

公开(公告)号：US20100022461A1

公开(公告)日：2010-01-28

申请号：US12307153

申请日：2007-07-02

Applicant: Hyun Chul Cho ,  Yonghyun Choi ,  Jonghan Yhei

Inventor： Hyun Chul Cho ,  Yonghyun Choi ,  Jonghan Yhei

IPC: A61K31/215 ,  C07C69/75 ,  C07C69/74 ,  C07C69/94 ,  C07D213/79 ,  C07H13/02 ,  A61K31/216 ,  A61K31/44 ,  A61K31/7004 ,  A61P17/00

CPC classification number: C07C69/013 ,  C07C43/184 ,  C07C43/188 ,  C07C49/175 ,  C07C69/24 ,  C07C69/533 ,  C07C69/587 ,  C07C69/716 ,  C07C69/738 ,  C07C2601/14 ,  C07D213/80

Abstract: Disclosed is tonovel cyclic derivatives having potent inhibiting effect on melanin formation and skin hyper-pigmentation activity with no adverse response to skin. They can be used as the therapeutics for treating and preventing the skin disease caused by over-reproduced melanin.

Abstract translation: 公开了具有对黑色素形成和皮肤超色素沉着活性具有强效抑制作用的tonovel环衍生物，对皮肤无不良反应。 它们可以用作治疗和预防由过度再生的黑色素引起的皮肤病的治疗剂。

公开(公告)号：US20090214530A1

公开(公告)日：2009-08-27

申请号：US12174215

申请日：2008-07-16

Applicant: Soo Kie Kim ,  Seung Kyu Park ,  Su Jung Park ,  Hyun Chul Cho

Inventor： Soo Kie Kim ,  Seung Kyu Park ,  Su Jung Park ,  Hyun Chul Cho

IPC: A61K31/7088 ,  A61K39/395 ,  A61P35/00

CPC classification number: A61K39/39 ,  A61K39/12 ,  A61K39/292 ,  A61K2039/55505 ,  A61K2039/55561 ,  C12N2730/10134

Abstract: The present invention relates to a modified CpG oligodeoxynucleotide (ODN) which is prepared by coupling a consecutive sequence of deoxyribothymine (dT) to the 3′-terminus of CpG ODN having immunoregularory function, thereby improving immunoactivity of splenocytes, macrophages and peripheral mononuclear cells, and therefore, can be effectively used as a vaccine adjuvant for preventing and treating hepatitis B or an anticancer agent. Since the phosphorothioate CpG ODN having the consecutive sequence of dT at its 3′-terminus shows high activity inducing Th-1 immune response and does not elicit in vivo toxicity with guaranteeing its safety, it can be effectively used as a vaccine adjuvant.

Abstract translation: 本发明涉及通过将连续的脱氧胸腺嘧啶（dT）序列与具有免疫赋形功能的CpG ODN的3'末端偶联制备的修饰的CpG寡脱氧核苷酸（ODN），从而提高脾细胞，巨噬细胞和外周单核细胞的免疫活性， 因此可以有效地用作预防和治疗乙型肝炎或抗癌剂的疫苗佐剂。 由于在其3'末端具有dT连续序列的硫代磷酸酯CpG ODN显示高活性诱导Th-1免疫应答，并且不引起体内毒性并保证其安全性，因此可有效地用作疫苗佐剂。