公开(公告)号：US20220280564A1

公开(公告)日：2022-09-08

申请号：US17281095

申请日：2021-02-23

Applicant: Immatics US, Inc.

Inventor： Melinda MATA ,  Mamta KALRA ,  Ali MOHAMED ,  Steffen WALTER ,  Yannick BULLIARD

IPC: A61K35/17 ,  C07K14/725 ,  C12N5/0783

Abstract: An in vitro method of expanding γδ T cells includes isolating γδ T cells from a blood sample of a human subject, activating the isolated γδ T cells in the presence of an aminobisphosphonate and/or a feeder cell and at least one cytokine, expanding the activated γδ T cells, and optionally restimulating the expanded γδ T cells.

公开(公告)号：US20190216852A1

公开(公告)日：2019-07-18

申请号：US16250679

申请日：2019-01-17

Applicant: Immatics US, Inc.

Inventor： Mamta KALRA ,  Agathe BOURGOGNE ,  Ali MOHAMED ,  Steffen WALTER

IPC: A61K35/17 ,  C12N7/00 ,  C12N15/85 ,  A61P35/00

CPC classification number: A61K35/17 ,  A61P35/00 ,  C12N7/00 ,  C12N15/8509

Abstract: The present disclosure relates to T cells transduced with a viral vector at a volumetric concentration for immunotherapy and methods thereof. In another aspect, the present disclosure relates to the assessment of optimal lentiviral vector concentrations for transducing T cells. The present disclosure further provides for T cell populations produced by methods described herein.