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公开(公告)号：US11266799B2
公开(公告)日：2022-03-08
申请号：US15759447
申请日：2016-09-09
Applicant: Impel NeuroPharma, Inc.
Inventor： Christopher Fuller , John D. Hoekman , Craig Kohring
Abstract: A delivery device for a compound including: a housing, vial holding a compound; and a source of propellant, wherein the housing provides an inlet and an outlet for the vial, wherein the inlet is in fluid communication with the source of propellant and is directed against the in-line nasal delivery device compound and the outlet allows for delivery of the compound.
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公开(公告)号：US20210322689A1
公开(公告)日：2021-10-21
申请号：US17164371
申请日：2021-02-01
Applicant: Impel Neuropharma, Inc.
Inventor： John D. Hoekman , Michael Hite , Alan Brunelle , Joel Relethford
Abstract: A nozzle for use in delivering a mixture of aerosol propellant and drug formulation. The nozzle includes a drug product inlet configured to receive a mixture of aerosolized propellant and an intranasal dosage form. The inlet is disposed at the proximal end. A nozzle body is secured to the drug product inlet. Two or more channels are disposed within the body. Two or more orifice apertures are disposed at the distal end of the nozzle.
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13.发明申请公开(公告)号：US20210236485A1
公开(公告)日：2021-08-05
申请号：US17148154
申请日：2021-01-13
Applicant: Impel Neuropharma, Inc.
Inventor： John D. Hoekman , Kelsey H. Satterly , Stephen B. Shrewsbury , Scott Youmans , Christopher Fuller
IPC: A61K31/4985 , A61K9/00 , A61K31/522 , A61K47/26 , A61P25/06
Abstract: Methods are provided for reducing the frequency of migraine attacks in a subject who has frequent migraine headaches with or without aura. The methods comprise intranasally administering to the subject a pharmaceutical composition comprising dihydroergotamine (DHE) or salt thereof on a repeat dose schedule, wherein each intranasal administration is delivered by a manually actuated, propellant-driven, metered-dose administration device, and wherein the schedule is a chronic intermittent schedule in which each of the repeated administrations is performed while the subject is experiencing a migraine headache.
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公开(公告)号：US20200078544A1
公开(公告)日：2020-03-12
申请号：US16664588
申请日：2019-10-25
Applicant: Impel Neuropharma, Inc.
Inventor： John D. Hoekman , Michael Hite , Alan Brunelle , Joel Relethford , Rodney J.Y. Ho
Abstract: A compound delivery device for delivering a plume derived from a propellant and a drug formulation. The drug formulation is in an intranasal dosage form in the form of powder, suspension, dispersion or liquid. The propelled intranasal dosage form is deposited within the olfactory region of the nasal cavity. The drug deposited within the olfactory region is delivered to the brain avoiding the blood-brain-barrier. Hydrofluoroalkane propellant from a pressurized canister is channeled to a diffuser and drug-containing chamber where the intra-nasal dosage form is aerosolized. The aerosolized intra-nasal dosage form passes through a nozzle thus delivering a plume to the olfactory region of a user's nasal cavity.
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15.发明申请公开(公告)号：US20200046667A1
公开(公告)日：2020-02-13
申请号：US16517423
申请日：2019-07-19
Applicant: Impel Neuropharma, Inc.
Inventor： John D. Hoekman , Kelsey H. Satterly , Inna Dashevsky , Aditya R. Das , Stephen B. Shrewsbury , Gregory J. Davies , Bhavin Y. Gajera
IPC: A61K31/198 , A61K9/00 , A61P25/16
Abstract: A dry pharmaceutical composition is provided that is suitable for respiratory tract delivery of levodopa and DDI for treatment of Parkinson's disease or Parkinson syndrome. The dry pharmaceutical composition comprises levodopa, a dopa decarboxylase inhibitor (DDI) and at least one excipient. A unit dosage form of the dry pharmaceutical composition and a method of treating a patient with Parkinson's disease or Parkinson syndrome by administering the dry pharmaceutical composition are also provided.
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Patent Agency Ranking
公开(公告)号：US20170043109A1
公开(公告)日：2017-02-16
申请号：US15338097
申请日：2016-10-28
Applicant: Impel NeuroPharma Inc.
Inventor： John D. Hoekman , Michael Hite , Alan Brunelle , Joel Relethford , Rodney J.Y. Ho
CPC classification number: A61M15/08 , A61M11/02 , A61M2202/0468 , A61M2202/064 , A61M2205/073 , A61M2205/8225
Abstract: A compound delivery device for delivering a plume derived from a propellant and a drug formulation. The drug formulation is in an intranasal dosage form in the form of powder, suspension, dispersion or liquid. The propelled intranasal dosage form is deposited within the olfactory region of the nasal cavity. The drug deposited within the olfactory region is delivered to the brain avoiding the blood-brain-barrier. Hydrofluoroalkane propellant from a pressurized canister is channeled to a diffuser and drug-containing chamber where the intra-nasal dosage form is aerosolized. The aerosolized intra-nasal dosage form passes through a nozzle thus delivering a plume to the olfactory region of a user's nasal cavity.
Abstract translation: 一种用于输送衍生自推进剂和药物制剂的羽流的复合递送装置。 药物制剂是以粉末，悬浮液，分散体或液体的形式的鼻内剂型。 推进的鼻内剂型沉积在鼻腔的嗅觉区域内。 沉积在嗅觉区域内的药物被输送到大脑，避免了血脑屏障。 来自加压罐的氢氟烷烃推进剂被引导到扩散器和含药物的腔室，其中鼻内剂型被雾化。 雾化的鼻内剂型通过喷嘴，从而将羽流输送到使用者鼻腔的嗅觉区域。
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公开(公告)号：US09550036B2
公开(公告)日：2017-01-24
申请号：US14017048
申请日：2013-09-03
Applicant: Impel NeuroPharma Inc.
Inventor： John D. Hoekman , Michael Hite , Alan Brunelle , Joel Relethford , Rodney J. Y. Ho
CPC classification number: A61M15/08 , A61M11/02 , A61M2202/0468 , A61M2202/064 , A61M2205/073 , A61M2205/8225
Abstract: A compound delivery device for delivering a plume derived from a propellant and a drug formulation. The drug formulation is in an intranasal dosage form in the form of powder, suspension, dispersion or liquid. The propelled intranasal dosage form is deposited within the olfactory region of the nasal cavity. The drug deposited within the olfactory region is delivered to the brain avoiding the blood-brain-barrier. Hydrofluoroalkane propellant from a pressurized canister is channeled to a diffuser and drug-containing chamber where the intra-nasal dosage form is aerosolized. The aerosolized intra-nasal dosage form passes through a nozzle thus delivering a plume to the olfactory region of a user's nasal cavity.
Abstract translation: 一种用于输送衍生自推进剂和药物制剂的羽流的复合递送装置。 药物制剂是以粉末，悬浮液，分散体或液体的形式的鼻内剂型。 推进的鼻内剂型沉积在鼻腔的嗅觉区域内。 沉积在嗅觉区域内的药物被输送到大脑，避免了血脑屏障。 来自加压罐的氢氟烷烃推进剂被引导到扩散器和含药物的腔室，其中鼻内剂型被雾化。 雾化的鼻内剂型通过喷嘴，从而将羽流输送到使用者鼻腔的嗅觉区域。
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公开(公告)号：US20140083424A1
公开(公告)日：2014-03-27
申请号：US14075126
申请日：2013-11-08
Applicant: Impel NeuroPharma Inc.
Inventor： John D. Hoekman , Michael Hite , Alan Brunelle , Joel Relethford
IPC: A61M15/08
CPC classification number: A61M15/08 , A61M15/0021 , A61M16/127 , A61M16/208 , A61M2202/064 , A61M2210/0612 , A61M2210/0618 , A61M2210/1067 , A61M2210/1475 , B05B1/14 , B05B7/08
Abstract: A nozzle for use in delivering a mixture of aerosol propellant and drug formulation. The nozzle includes a drug product inlet configured to receive a mixture of aerosolized propellant and an intranasal dosage form. The inlet is disposed at the proximal end. A nozzle body is secured to the drug product inlet. Two or more channels are disposed within the body. Two or more orifice apertures are disposed at the distal end of the nozzle.
Abstract translation: 用于输送气溶胶推进剂和药物制剂的混合物的喷嘴。 喷嘴包括配置成接收雾化推进剂和鼻内剂型的混合物的药物产物入口。 入口设置在近端。 喷嘴体固定在药品入口上。 两个或多个通道设置在体内。 两个或多个孔口设置在喷嘴的远端。
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公开(公告)号：US11185497B2
公开(公告)日：2021-11-30
申请号：US17062364
申请日：2020-10-02
Applicant: Impel Neuropharma, Inc.
Inventor： John D. Hoekman , Kelsey H. Satterly , Stephen B. Shrewsbury , Scott Youmans , Christopher Fuller
IPC: A61P25/06 , A61K9/00 , A61M11/00 , A61M11/02 , A61M15/00 , A61K31/48 , A61K31/522 , A61K47/26 , A61M15/08
Abstract: Methods are provided for acutely treating migraine headache with or without aura. The methods comprise administering to a subject with migraine headache an effective dose of a liquid pharmaceutical composition comprising dihydroergotamine (DHE) or a salt thereof, wherein the dose is administered by an intranasal delivery device that provides, following intranasal administration, (a) a mean peak plasma DHE concentration (Cmax) of at least 750 pg/ml, (b) with a mean time to Cmax (Tmax) of DHE of less than 45 minutes, and (c) a mean plasma AUC0-inf of DHE of at least 2500 pg*hr/ml. Also provided are kits for acutely treating migraine with or without aura in which a liquid pharmaceutical composition comprising DHE or DHE salt is contained within a sealed vial that is attachable to a precision intranasal olfactory delivery device packaged therewith.
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公开(公告)号：US11007332B2
公开(公告)日：2021-05-18
申请号：US15844474
申请日：2017-12-15
Applicant: Impel NeuroPharma Inc.
Inventor： John D. Hoekman , Michael Hite , Alan Brunelle , Joel Relethford
Abstract: A nozzle for use in delivering a mixture of aerosol propellant and drug formulation. The nozzle includes a drug product inlet configured to receive a mixture of aerosolized propellant and an intranasal dosage form. The inlet is disposed at the proximal end. A nozzle body is secured to the drug product inlet. Two or more channels are disposed within the body. Two or more orifice apertures are disposed at the distal end of the nozzle.
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